Description | Mediator of RNA polymerase II transcription subunit 4 |
Sequence | MNVEFQGTLSNLENKLNALITSLTTSPTAAGAPAAAVGLLDADDSLTSAVETLRQHQQNYAKILRLREEAQVLEEKVKSIVREVVAYEKEIRTTCGDDEESDSDLEFEDDSSDYDSDNDIPGEKPRSGGLRGIKEVDYKLLLDFARRISKYNHQAAADAAVNAESRSREKLQGVKGPDTEVTGANGNTDGEAVEPVASVTKEATSWLDESANLTRQAYMLPYPMEDRIRMGLMAQIQLAGGEGRPGFDPDMEVERLIREAEGVGIADAVPQVDVGEEARHADEAAKAAAHAGSAATSRSTMGAAPAPKPKATLDLDLYDPDDDDE |
Length | 325 |
Position | Middle |
Organism | Aspergillus sclerotioniger CBS 115572 |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Aspergillus. |
Aromaticity | 0.04 |
Grand average of hydropathy | -0.594 |
Instability index | 36.30 |
Isoelectric point | 4.43 |
Molecular weight | 34994.04 |
Publications |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364141 |
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro |
Binary Interactions |
Repeats | >MDP21396 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 47.86| 14| 131| 154| 167| 2 --------------------------------------------------------------------------- 154- 167 (23.66/14.76) QAAADAAVNAESRS 286- 299 (24.20/15.26) KAAAHAGSAATSRS --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) KAAAHAGSAATSRSTMGAAPAPKPKATLDLDLYDPDDDDE 2) LRGIKEVD | 286 130 | 325 137 |
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