<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP21382

Description Mediator of RNA polymerase II transcription subunit 5
SequenceMTSSEQWGIFLRRCLLHRIDAAEFKSLTRLLLQRCPIAEAPLLDVLLETRLATGIKWDPLLPLYIDCLCKMGLVQTSTVLNCLLKYSSIHDKPQPPGQEAVQIKQRQKCYTLMTDIRVVQDAMLSVSTGTTPKTFSEAICIFNAIVDWIQAVVAWHNGHMDASHQTGGLMGSPDAVSLFESLGILLAALSGTGKGLEVLSAVSHEALKIKLGQALSAYLPLCVEVSLPLRNRLDSLQKEFGLFGEPPSKALDVSMMGNVNVNALQFEDSVMDGPMINSRAGLYVYINAMLVGRPLVDDSMLLNYLSNRYGGHYQALIEETITATFDVLSNASYRNESSRSMFLFRSFLVNKLPSFIAAMLAASMVSLPMELCISHALSRLDPNTFPSFSQMFAMQSNTALSDVRQEFLFACALHKLIPESSIERLLGENPMQTLPVGGPYNKDELVSQINANPERAEQLINEIESMEGNAGAIVGAITDVMHHLCNQKETMTLKNICNSLSRRVQALDVILLFRSARQVLQPLCALLDAWHWDEDQGESQPVYDEFGSILLLVLTFKYRYDLRPCDIGIGGNPSFVLRLLEGGSGSEKLDDLNEKQNKNLGAWINALFIAEGISEETMSSCSPQEFYILVTTLFSQSLGACEAGKLEFDTLKGGFEYLLEPFLLPSLVLALNWLGNHIWETENDPTISLKALQSLVTPSSISGEAKEIHRTVLNITARSLEEQLKDVRARHPSRTDIKPIMDALEPYLSFQRSGSCHRSEFEPWTTHSPGGLLGSMRNTFQSLVLWSTSPDMSMAPQSYTHRQLIAGIRVQGSTRVLAALVEELKLQTEAGNGDLALDIVATLICAPLAESFAVDQNNYSQHPIDPTKEPLPRCPILTLRDALFLLHENVPKISEKDPLRAEVIVRLYRRVNVLMTPPTQVPNLDMNNIIQNMQLGVGGPGQMDLDSSGGPGHDDNINQILDSAAAAVGMDGGQSMGGMGNMGLESSGGGLDTSIDDVLNAADMAVGNPEFLDLDMEGLF
Length1020
PositionTail
OrganismAspergillus heteromorphus CBS 117.55
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Aspergillus.
Aromaticity0.06
Grand average of hydropathy-0.006
Instability index47.19
Isoelectric point4.93
Molecular weight111993.28
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP21382
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     262.82|     102|     600|      23|     249|       1
---------------------------------------------------------------------------
   32-   60 (10.99/167.71)	.....................................................................................LQRCPIaeAPLLD..VLLETRLATGIKWDPL
  172-  249 (95.26/37.76)	SPDAVSLFESLG..ILLAALSGTGkGLEVLSAVSHEaLKIKLgQALSAYLPLCVEVSL...PLRNRLDSLQKEFGLFGEPPSK.................................
  789-  899 (156.57/68.63)	SPDMSMAPQSYThrQLIAGIRVQG.STRVLAALVEE.LKLQT.EAGNGDLALDIVATLicaPLAESFAVDQNNYSQHPIDPTKepLPRCPI..LTLRDalFLLHENVPKISEKDPL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     118.69|      24|      68|     926|     949|       2
---------------------------------------------------------------------------
  926-  949 (44.35/23.64)	MNNIIQNMQLG..VGGPGQMDLDSSG
  963-  988 (36.26/18.08)	SAAAAVGMDGGqsMGGMGNMGLESSG
  995- 1018 (38.07/19.33)	IDDVLNAADMA..VGNPEFLDLDMEG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     131.81|      42|      68|     325|     368|       3
---------------------------------------------------------------------------
  325-  368 (68.37/47.21)	FDVLSNASYRNesSRSMFLFRSFLVNKLP.SFIAAMLA.ASMVSLP
  392-  435 (63.44/37.98)	FAMQSNTALSD..VRQEFLFACALHKLIPeSSIERLLGeNPMQTLP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     119.76|      38|     600|     114|     171|       4
---------------------------------------------------------------------------
  114-  171 (54.56/66.11)	TDIRVVQDAMlsvstgtTPK.TFSEA.ICIFNAIVDWiqavvawhnghmdASHQTGGLMG
  735-  774 (65.20/36.79)	TDIKPIMDAL.......EPYlSFQRSgSCHRSEFEPW.............TTHSPGGLLG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.23|      17|     374|      14|      30|       6
---------------------------------------------------------------------------
   14-   30 (29.65/16.28)	CLLH...RIDAAEFKSLTRL
  372-  391 (28.58/15.46)	CISHalsRLDPNTFPSFSQM
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP21382 with Med5 domain of Kingdom Fungi
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