<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP21379

Description Mediator of RNA polymerase II transcription subunit 16
SequenceMPLIMEDSINVDDLFGEPTSLELGLPPAASSPKGLAQRLDEMRLLGCCQKIAWSKLGCIAYISQDSSKVNVRHLQCRPSDGKWALSEETPLLPITEANGGHPLAHLSWNEAGSELAVIDLSGRISIYSIPISLNSVNGLRQPAFDPDDGSQIVGMMWLNTQRSVHAFYQAAKVQGRWAYSPFRRRPVGPFHPANKAALVCITRSGIMKLLYQNPDGRWAEISAELKNTSYSDRLLTHAALVATQNGVLVATYSACQKICFYRVQINWTPSQWDPAQQPRQPTQFPVPSFRFTHCKVETAGNVPGNRSGEEPDLHSFSNPLYCLSRLEIILPASDNAVGSTASPWIVAIFSTPPQVAQGHTHQQGPASVIVRWQLDTAAFTLHPKFDEMAAKRTNAQTKPRTVLRRLDDICSDRYVISVDHMEYGNVLAITYDDSSVAFYDPKTMAVFNGIDDGNTVTSLAQAGFHYTPDTTGQHISFSPSACAAVMLDGDGRTHLRVVEHSYGAENGLYDENKFSAAIASLTLAYCRGCGSEVNTDDILLILIRQLSTDAQTTFINEVYRALPINCNFTVEQDKLMNHPYIPRCLSIQASLGFKDKYTARSFASSVSWSILQLRHASILYPFFFQYNKGMQTEPHDPDVLRMMLGNTKWALDFCLYILNELFDLADEFESLSNDQEAFNQKLKTTNSLSLIMLLSSMSRAFLRFICRGLRGIPAGYANAPLTGDARTYYSEICQTVDASPARIDVYEKFLASVDSVVRHAYHGAGFGDAERPGPEKELLVNARIPPVLVAAVSTILRQTVPALRSDVDRMSIYMGDYGWLGLGSDRRSELYRRTREVDIIKKTPIRMTVSTGLDLSQGVKLNVQGQQQLRRRCVRCCEVSEGTYPPRSVLAFRMIFKLGHLRACICGGMWTIESGVNEVSK
Length921
PositionTail
OrganismAspergillus heteromorphus CBS 117.55
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Aspergillus.
Aromaticity0.09
Grand average of hydropathy-0.182
Instability index42.66
Isoelectric point6.88
Molecular weight102282.40
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP21379
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     172.63|      54|     209|      48|     142|       1
---------------------------------------------------------------------------
   73-  130 (86.58/91.68)	HLQCRPSDGKWA.LSEEtplLPITeANGGHPLAH..LSWNEAGSELAVIDLSGRISIYSIP
  208-  264 (86.06/39.21)	KLLYQNPDGRWAeISAE...LKNT.SYSDRLLTHaaLVATQNGVLVATYSACQKICFYRVQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.54|      13|     164|     636|     649|       2
---------------------------------------------------------------------------
  145-  161 (22.04/ 8.17)	DPDdgsqIVGMMWLNTQ
  636-  648 (25.51/17.90)	DPD....VLRMMLGNTK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      59.23|      17|     164|     177|     203|       3
---------------------------------------------------------------------------
  187-  203 (29.98/ 9.76)	VGPFHPANKAALVCITR
  355-  371 (29.24/26.62)	VAQGHTHQQGPASVIVR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     114.43|      35|     146|     540|     606|       4
---------------------------------------------------------------------------
  546-  580 (63.35/82.61)	LSTDAQTTF..INEVYRALP....INCNFTVEQDKLMNHPY
  721-  761 (51.07/15.04)	LTGDARTYYseICQTVDASParidVYEKFLASVDSVVRHAY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.75|      11|     209|     702|     715|       5
---------------------------------------------------------------------------
  705-  715 (22.04/15.78)	ICRGLRGIPAG
  905-  915 (23.72/ 8.23)	ICGGMWTIESG
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP21379 with Med16 domain of Kingdom Fungi
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