<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP21378

Description Mediator of RNA polymerase II transcription subunit 16
SequenceMPLMMDDSINVDDLFGEPSSLELDLPPSASTTKGLAQRLDEMRLLGCCQKIAWSKLGCIAYISQDTMRVNVRHLQCRPSDGKWVLSDETPLMPVAEAHGGHGLAHLSWNEAGSDLAVVDLSGRISIYHIPFALNSINGLRQPAFVPDDGSQVVGMMWLNTQRSVHAFYQAAKVQGRWAYSPFRRRPIGPFHPVNKAALLCITRSGSMRLLYQNPDGRWDDISTDLKSTSYSDRLLSHAALVATQNGILVATYSLCQKIRFYRVQINWNPPQWDPAQQPKQMPNHFPVPSFRFTHSKVETSFTVPGTQRNDGEMTDLQSASNPLYSLSCLDIILPASDNSVGSTANPWIVAVFSTPPQVTPDHPGQQGPASVIVRWQLDTAPFTLHPKFDEITSKRNSIQTKPRPVLRRLEDITSDRYVISVDQIEYGNVLAVTYDDSSVSFYDPKAMAVFNGVDDANTVTSLAQAGFHYAPDTSGQHISFSPSACAAVMLDSDGQTHLRVMEHSYGAENGLYDENKFSAAIASLTLAFCRGCGSEVNTDDILLILIQQLTPDAQITFINEVYRALPINCNFTVEQDKLMNHPYIPKCLSIQAALGFNNKYKPRSFASSVSWSILQLRHASILYPFFFQYNKGIQAEPHDPDVLRMVLGNTKWALDFSLYILNELFDLADEFENLSADQEAFSQKLKTTNSVALIILLSSMSRAFLRFICRGLRGIYAGYNAPLTGDSRLQYAEICQALDTCPMRIDVYEKFLAGVDSAVRHAYHGAGFGDAERPGPEKELLVNARIPPVLVTAVSTILRQTVPGIKSDVDRMAIYMGDYGWLGFGTDRRSEWYRRTREVDIIKKTPIRMTVTQGSNGPQVGKSNNQGLLRRRCVRCCDVSEGTYPPRSVLAFRMIFKLGHLRSCICGGMWTVESGSNEGTK
Length921
PositionTail
OrganismAspergillus sclerotioniger CBS 115572
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Aspergillus.
Aromaticity0.09
Grand average of hydropathy-0.210
Instability index41.49
Isoelectric point6.63
Molecular weight102480.47
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP21378
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.89|      13|      40|     163|     177|       1
---------------------------------------------------------------------------
  163-  177 (21.55/18.62)	SVHAFYQAAkvQGRW
  206-  218 (27.34/16.78)	SMRLLYQNP..DGRW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     288.68|      94|     209|      48|     151|       2
---------------------------------------------------------------------------
   48-  151 (147.24/132.66)	CQKIAWSKLGCIAYISQ.DTM...RVNVRHLQCrPSdGKWVLSD.ETPL.MPVAEAHGGHgLAHL.SWNEAGSDLAVVDLsgrIsiyhIPFALNSINGLRQPAFV..........PD.DGSQ
  255-  366 (141.44/95.79)	CQKIRFYRVQINWNPPQwDPAqqpKQMPNHFPV.PS.FRFTHSKvETSFtVPGTQRNDGE.MTDLqSASNPLYSLSCLDI...I....LPASDNSVGSTANPWIVavfstppqvtPDhPGQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     109.10|      35|      36|     811|     846|       3
---------------------------------------------------------------------------
  811-  846 (61.93/38.85)	RMAIYMGDYG.WLGfGTDRRSEWYRR.TREVDIIKKT.P
  848-  885 (47.17/24.62)	RMTVTQGSNGpQVG.KSNNQGLLRRRcVRCCDVSEGTyP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      95.46|      29|      36|     532|     560|       5
---------------------------------------------------------------------------
  532-  560 (48.36/34.71)	CGSEVNTDDIL..LILIQQLTPDAQITFINE
  569-  599 (47.09/33.60)	CNFTVEQDKLMnhPYIPKCLSIQAALGFNNK
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP21378 with Med16 domain of Kingdom Fungi
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