<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP21376
Description |
Mediator of RNA polymerase II transcription subunit 19 |
Sequence | MSDRASSASFRVGPLSPSSPAAGSLKQSQPPSVLSDRIPQTPTSPPLMSVSAQNYATNLASSQTSPNQATSQPANLSSPPSSAPMSHQASQQPTVGTANSFPTPASSVSGHIPNANSFDESEPADKPMGTEPGATTATMNAAAMQQAEHRRTDHDRDLGGMGPAIGVRDFADVNGESDAMDIDREAPALSLHNGPSLESLQKDFSSAFHLCKSSYSATGPDPAVDLISLYGLGPVAHSVARLDSVTGEKINRLRKSYEGKLKGLGLAGRNKPVKQEPGAPGGLRHLTMWPEEEWQNQKVFGKEIKVADMDSALHNLQMKAMKMEPGTVPNNDYWEDVLGHEKPSKHAGSGDAGKKAVGAPPNGIRITQPNGTPAPVTDSERARPSRGRKRHYDENSFVGYGEGYADDDDEGAFYSNSEGIGKKKRKKDHVSKISTPLPDRGGSYGVGMFGIGAR |
Length | 454 |
Position | Head |
Organism | Aspergillus heteromorphus CBS 117.55 |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes>
Eurotiomycetidae> Eurotiales> Aspergillaceae> Aspergillus.
|
Aromaticity | 0.05 |
Grand average of hydropathy | -0.734 |
Instability index | 48.32 |
Isoelectric point | 6.51 |
Molecular weight | 47989.55 |
Publications | |
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364151
|
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP21376
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
4| 188.80| 37| 37| 62| 98| 1
---------------------------------------------------------------------------
16- 48 (54.13/22.25) SPSSPAAGSLKQSQPPSV.LS......DRI.PQTPTS.PP..LM
49- 77 (37.58/13.45) SV.........SAQNYATNLA.....sSQTSPNQATS.QPANLS
78- 116 (53.07/21.69) SPPSSAPMSHQASQQPTVGTA.....nSFPTPASSVSgHIPNAN
117- 158 (44.02/16.88) SFDESEPADKPMGTEPGATTAtmnaaaMQQAEHRRTD.HDRDL.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 63.18| 17| 31| 314| 330| 3
---------------------------------------------------------------------------
314- 330 (32.37/16.43) HNLQMKAMKMEPGTVPN
346- 362 (30.81/15.33) HAGSGDAGKKAVGAPPN
---------------------------------------------------------------------------
|