<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP21375

Description Mediator of RNA polymerase II transcription subunit 12
SequenceMIPHPSAGVQPWGRSVRALNNGSGRVDASQTLGQPEPQLEKLSMPMPQSLPRQPAVVDLTTNPSDSQEREPPTKRLKVDAPSGSCPVEGSPAPGSGGEARSTPGTQSSKPNPLSWRGRPVWSFQALVSETTGAAEAKDGDATSQGKNPASPPPLPLVPWKYTPQEPSGSNSTRPPDIAPTKEVQTTPYRIVVPPVAPKVKGERVADFSPWTGNHPEDTLNDHTAKQGHYDRTQVSQNESNTARPSLYAQLKHRSGLQMLSSVFAAALEKRQSHNTVTAPSSFKPPPRVTLTDNKREAWLRDLANPSVPLRRLSRTIPHGVRGKVLLDQCLGKGIPVPRAIWLARCVGANEIRAFKRKGTSGALALGLETKWVRDWTSTVQQFLESVIGTCGTPDWKLKMTYAVSLTSRLFFERLLDHDQYLAWFLLSLEAAPINTVPVWLLMLGIYWNNIMRYRKRGRRLAEVLLEKLRQIKQPAQPTALEPLVDRLSRCVRRLVLEHTSSVILPNSWEKYKDLVASCLNLNETPDKTTLQNLAERNARVQLPNSHQETAQRLPQQHVIHLFDSIRSAHDISSTSSTCLGAVEDKASLVSKLLEWASTPFRHGSRRVYTSVRLLRKWKMSGMDVESHILAFLADVHITSRVNMDNVYHIIAELVRSQTFSVGRYLQWLMAKGVANDPSPGQQQAISDDLCLLMQLPLARLPEYVRNLRNTLLSRAGMPASQEESIIAAVKASIAQRLPKIFGAQISDAMLTDLSLPSLTWAVKSEIGLWIRRGVSGHHRDPIRKYAHIPMLADSGVSALTPVEFYNIRDVLESFGDISMLADVLKQATNCDDGVVLASVADTVNYHFDSLCVIGAATDLFKGLVESYARLKRFGAPSLDLIFSLIELGLRMPSEFNTVALLRQDLSRIENKSALAAPSPLSDHIPMGGFGEFDSSFQEKLDQILFSGGGMDEATMDAIFNSLTRALGTEHSPVKLSANDICRYMAYLRSFHPKRFDARLVRWVCGLLKSPSRSALVRILPPLIGVGCVTIHAFVVLVKKLLQMERVASVVPKVTDLRLDLLELLIPKGPGQGRYADMVTYRYYLAQQEFIDKHPEECLEIIRDAVPLVHTRHPGTACVTNQTDLVTCAMNLLQTLLTQKPERMVQCCMQKFIGQDLAATALLQKALDTLLGFDSQDPQAMPEAERVIGMNNDFSLPICQLKLQVLFNAEAGNKVDNGIVDVMFKAAMADARSKRSHWYGLVSLMSQDAVRQIRERAEKGFFSVPMLEEPIGDPTVADTSNSIETARLYLTVVEKLAHSIPEAGAHTIASTLVERMELLLQKFITMQPNGSGAVDASQTAQVRSNFERSLAFWFSALLRLVVIHRAAFNIPALAPRLNGLQEQARILIAIFCISLARLPDRVIRLYPSANYFPHPVQSENYRPCPGILLQTHALDVAAALIDTFPDEARQQCARFLREKCPPFLQFQNDFRFLYLLGPMLDTSSPHPPQPVSLPSPAAGGSTPTPTANLAGGPPNPQQTISSTPSGLPGGLAEGVNCIASHLRLQYRGRVIGAYPVRPWELLEDAAPIVGMNDTAVSLKYFDARRVRA
Length1587
PositionKinase
OrganismAspergillus sclerotioniger CBS 115572
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Aspergillus.
Aromaticity0.07
Grand average of hydropathy-0.183
Instability index48.85
Isoelectric point9.01
Molecular weight175297.56
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.


Component of the srb8-11 complex. The srb8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The srb8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP21375
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     241.45|      55|      69|      55|     109|       1
---------------------------------------------------------------------------
    3-   53 (53.71/26.62)	........PHPSAGVQP....WGRSVRaLNNGS.GrvdASQTLGQP.EPQL..E..KLSMPMPQSlpRQ
   55-  109 (96.39/54.56)	AVVDLTTNPSDSQEREP....PTKRLK.VDAPS.G...SCPVEGSP.APGSGGE..ARSTPGTQS..SK
  125-  163 (50.94/24.80)	ALVSETTGAAEAKDG..............DATSqG...KNP..ASP.PPLPLVP..WKYTP........
  165-  211 (40.40/17.90)	.......EPSGSNSTRPpdiaPTKEVQ.TTPYR.I...VVP....PvAPKVKGErvADFSPWT......
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     110.75|      36|      69|    1285|    1322|       2
---------------------------------------------------------------------------
 1285- 1322 (51.07/38.26)	ARLYLTVVEKLAHSIPeAGAHTIaSTLVERMELLLQKF
 1355- 1390 (59.67/35.86)	ALLRLVVIHRAAFNIP.ALAPRL.NGLQEQARILIAIF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     119.96|      40|      69|    1027|    1069|       3
---------------------------------------------------------------------------
 1027- 1069 (58.28/52.04)	CV.TIHAFVVLVKklLQMERVASVVPKvTDL...RLDLLELLIPKGP
 1097- 1140 (61.68/43.28)	CLeIIRDAVPLVH..TRHPGTACVTNQ.TDLvtcAMNLLQTLLTQKP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      74.32|      24|      70|    1169|    1197|       5
---------------------------------------------------------------------------
 1169- 1197 (35.76/38.73)	LLGFDSQDP..QAMPEAERviGMnndFSLPI
 1240- 1265 (38.55/24.84)	LVSLMSQDAvrQIRERAEK..GF...FSVPM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      74.92|      23|     312|     336|     393|       7
---------------------------------------------------------------------------
  298-  324 (30.41/55.76)	WLRDLAnpSVPLRRLSRTIphGVRGKV
  371-  393 (44.51/11.51)	WVRDWT..STVQQFLESVI..GTCGTP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      86.60|      26|      72|     499|     525|      10
---------------------------------------------------------------------------
  499-  525 (41.86/37.34)	TSSVILpNSWEKYKDLVASCLNLNETP
  574-  599 (44.75/33.46)	TSSTCL.GAVEDKASLVSKLLEWASTP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP21375 with Med12 domain of Kingdom Fungi
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