<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP21367

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMEFPGGSITNIRVIDGFSHIYWRIYTEEPNIANNPGEPPANGYTILKHLSRLKDLELQLRDRDCLVSSYPRRLCLWLFSATPGFESLTSFPPTEGKDESNRIAIGSATLKVSSSGSVSSSDLVKNLSTEPQNTSSSTGPQRPNALTPYATIYASFISAISGAVSLQLIRQRNAIPLGSRTLFTAVERDSYENSRVVKNDPISAPSLTTLQIQLTSVGKLTVALQTVSQAGLMRLRTPDDDPARVHETPPGTDLWLSPSGSIARLVTTNPPRTNAPSPYPPSAGSLGNEKPGVTNRKQWKVNVLWWLANFGLPVDDIEEDAWVEVEVWEPFYSRLAGEVLRPNDEGSSTLPLKRILWPANYCFKRTKSASSDSFGQMESVCPVVGDPLDFAEKWRVTEKPNFTNASPKPPSVHPEPPASDQDAASPDIISLSEGFDSLSRASQYPELQTASLVYPTPPDGAATAGLVPTLSSDAFAEDLDHGSTFMQPSRQAHYAQPPGKDRVENGLEMDFGPSAGLMVGSGLYDTNEDDDLFGDINERDFGSKGITDADFSFFDDPDFDHGGRVDQADPVHETPAFMDTDEPCMPPAVTDPTSPDQTPALHIDFPRLSPINETPEVQPETTAPDHRASPPPGDDNVVAISPPLSPVEVKKILFPEPQVGSQSMKMPGYYNAVAFKHNMSIWDQKYRADGKFGFTVRGMDAPKIANAATGDIPTIGLPRRSGKIKTGGVLREPDGHQSPTSGAVEQLSSDSESSSSASGESDESDSEVGFSPATFSTRKRKRTRSNSGTSLALSQEKAPLGADQDTPTHRPEDSVFLGNFLSTFSDWSMAGFFSLAQNQVSPVLLRRDIQVQIAQLLVDQITQSSLDHKFDDTLGLSDCDDEAYTVQPPLGDPTSVDRMDRLDLNGFISLQDANLIPPPTSNGANARQSSQRRDTSKGTILKIPPPHLRVRRGKDFLETLPPAISFWETFGLEPAHGQKDIFAYCIHPQFAAEAADAFLERLGLVYSGCNLGTHSRGDRSNFFDRGLGSWDVSLSAESRYSEVMKSLKAICEELGTAFLRSPSSKDSNLVIYIINPFTHAAASVDICSAFWFLFQKYVADADRQQAQQLNELVLQILPIDFIMSAESLVVPPQAEYLNLALEVYSRCPPKSSQPSLVNCAPPVLLAEHLPKAIGFRLSSEGSSPLQEGRCLHVACSRSLDQRWISVAWSDSTGALQRNMSYCLRFRNSLATRTLLEVRGEIWKATKDIMERIQARWRVIIVNTDPVDQEEVDTWSTFADQYGKAKSTTVDLVVLSVNTSPDLLLEPPFLPIPTNLFNGHPSSTPVATPNLAASISSPDQLGNAPTPPGGGGAAAGASTPTDALPEVESESQLTDICDETWGVVLSHRLNSSLHQTEYRPALASGYLLRRKGSTDGDGLYTMNINIIYTRRPPSSYDTLLREILGMHRDLATLARARGTRTVQNGTLPWHIATAAKAQTMLSYVL
Length1483
PositionKinase
OrganismAspergillus heteromorphus CBS 117.55
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Aspergillus.
Aromaticity0.08
Grand average of hydropathy-0.381
Instability index51.62
Isoelectric point5.01
Molecular weight161710.97
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP21367
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     785.37|     167|     175|     394|     568|       1
---------------------------------------------------------------------------
   23-  152 (83.58/37.03)	..............................................................RIyTEEP...NIAN.N.P.......GEPPANgytilkhlsrlkDLELQLRDrdclvssyprrlclwLFSATPGFESL..............TSFPptegkdesnRIA...IGSATLKVSSSG..S........VSSSDLVKNL...STEPQNTS.............SSTGPQRPNA..........LTPYATIY
  176-  350 (176.79/88.49)	LGS........RTLFTAV.ERDsYENSRVVKND..PISAPslttlqiQLTSVGKL.TVAL..QT.VSQAglmRLRTPD.D.DPARVHETPPGT............D.......................LWLSPS.GSIARlvttnpprtnaPSPYP.........P.S...AGSLGNEKPGVT..NRKQWKVNVLWWLA.........NFGLPVDdieedawvevevwEPFYSRLAGEVLRPN....DEG.SSTLP
  351-  517 (249.48/142.27)	LKRILWPANY...CFKRTKSAS.SDSFGQMESVCPVVGDP......lDF.........AEkwRV.TEKP...NFTNAS.P.KPPSVHPEPPAS............DQDAASPD...............IISLSEGFDSLSR...........ASQYP.........ELQ...TASLVYPTPPDG..AATAGLVPTLSSDAFAEDLdhgSTFMQPSR.............QAHYAQPPGKDRVENglemDFGPSAGLM
  518-  667 (203.33/105.73)	VGSGLYDTNEdDDLFGDINERD.FGSKGITDADFSFFDDP.......DFDHGGRV.DQAD..PV.HETP...AFMDTDePcMPPAV.TDPTSP............DQ...TP..................ALHIDFPRLSP...........INETP.........EVQpetTAPDHRASPPPG.dDNVVAISPPLSPVEVKKIL.....FPEPQV.............GSQSMKMPG...................
  668-  749 (72.18/29.23)	...................................YYNAV.......AFKHNMSIwDQKY..RA.DGKF...GFTVRG.M.DAPKI....................ANAATGD...............IPTI..GLPRRS................G.........KIK...TGGVL..REPDGhqSPTSGAVEQLSSD..........................................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      67.62|      24|      29|    1108|    1136|       2
---------------------------------------------------------------------------
 1111- 1136 (38.10/30.30)	LVLQIL...PIDfiMSAESLV..VPP..QAEYL
 1138- 1168 (29.53/10.07)	LALEVYsrcPPK..SSQPSLVncAPPvlLAEHL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      99.85|      29|      34|    1298|    1328|       3
---------------------------------------------------------------------------
 1298- 1328 (49.98/42.32)	SPDLLLEPPFLPIPTNLFNGhpSSTPV.ATPN
 1335- 1364 (49.87/33.88)	SPDQLGNAPTPPGGGGAAAG..ASTPTdALPE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     102.38|      28|      29|     891|     918|       4
---------------------------------------------------------------------------
  871-  888 (19.07/ 6.97)	............DTL.GLSDCDDeAYTVQPP
  891-  918 (50.76/32.31)	DPTSV.DRMDRLDLN.GFISLQD.ANLIPPP
  921-  945 (32.56/17.75)	NGANArQSSQRRDTSkGTI.LK.....IPPP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      87.22|      27|      33|    1172|    1198|       5
---------------------------------------------------------------------------
 1172- 1198 (48.28/29.28)	IGFRLS.SEGSSPLQEGRCLHVACS...RSL
 1203- 1233 (38.94/22.17)	ISVAWSdSTGALQRNMSYCLRFRNSlatRTL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     170.63|      55|     642|     780|     843|       9
---------------------------------------------------------------------------
  780-  843 (78.35/78.23)	KRTRSNSGTSLalsqeKAPLGADQDTPT.HRPEDSVFLGNflSTFsDWSMAgFFSLAQNQVSPVL
 1428- 1483 (92.28/61.76)	RRPPSSYDTLL.....REILGMHRDLATlARARGTRTVQN..GTL.PWHIA.TAAKAQTMLSYVL
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP21367 with Med13 domain of Kingdom Fungi
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