<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP21363

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMPGVVMDDASIGGLRHGPGNNYSQDGQSYPRGETVRFNSQNDPPNVNGVEKNASHNRAIEIPPVNHALRGNKGPPDLPHITQGFFPFSKLINRSVQQCWNDLSDMITELAEMQVNPHEYHPSPVPTSGKYPGNQPPDNTRKKLRMLEFSHAKRAEFIKLLVLSQWSRQAADVSKLIDIQNFIRARHQAYTGALQCVGDMKRDLVQAQVANPDLKTALEVLSKGKVESMSNLGYKPPRRLTVRGTLKRLQKINRLIGVRLVARDEIPPSFRTYCVHDGRVTFLVPGEFELDLSIGEEDEASQFFFVDIRFLFFPSPPVPKGRFLNELEITINDVLQKSGLTGCFELLHNLVLTNKVNILFKQAAELARSSWSDVLRVELLHRTLVVQYWTLKPGAKSWLEIGIYRGQRRSNCESSGLPVLGCRWMRDGNEVPCDDIDFDSENLSMESLLRSIIALHVSHNLSSAYRNIGHSSLFSSGLLSLRARLTRTEPGDCLLDVQLTETKYLRVSIEPMSGISILSTTPSVSERIDGDRSFERSPVDDIVSRVARLRCNAAIEEIESKVKMLGFEPLNPRAWKVDFRKIFPSNVLRFAFFSHHLWERNWIVAATSSMDGDSWWVVQLRPTVLAKGPSLLDASGRGQSVLRSAQAVTNGFYPAQDKSDDASLADLGHSLSGILAIHSNARYLSELQAIRFYPPPHKLTIESDLGVPDILVRYNASNLPSVFRVAMPVNAKRKSFFKDTIRLAFHGIDPRKKCAIMVAYGSLANPTGAFGHLISNWDRSLVFQKTGGGFAIRLLAPAGHPVIVSLIESLQRLECVLSILESLQRRKIEVRTFSLSSISFIYGPERDLSASINIDLTSDDSLMELNPTQLTSSLESLFRLRLHIQFGHYNPHRRIQESLASSLNQASTEAGLESVVELLTLTLPLMRALDQLMVNSSHSEPLRVQVTVRNARTYQIHYPGEGVLFQLVAASHQSRWVWVLKDTGSQGNNRNHKVTTCLRETLYTSKGDGWRGLESGVVAEASQVGNLLVALEKCFTASRNGSGHKPTDRAASPGTSNITALSVSARATGNTDGTKSAHQDSLATLPNNKSTQSQANPATQKEDVIMID
Length1107
PositionTail
OrganismAspergillus sclerotioniger CBS 115572
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Aspergillus.
Aromaticity0.07
Grand average of hydropathy-0.271
Instability index47.48
Isoelectric point8.97
Molecular weight123058.67
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	ARBA:ARBA00003669
ECO:0000256	RuleBase:RU365082

GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP21363
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     217.55|      71|     203|     278|     388|       1
---------------------------------------------------------------------------
  307-  387 (105.50/146.09)	IRFLFFPsppvPKGRFLNELEITINDVLQKSGLTGCFELLhNLVLTnkvniLFKQAAEL.ARSSWSDVLRVELL...HRTLVVQY
  883-  957 (112.05/64.25)	IQFGHYN....PHRRIQESLASSLNQASTEAGLESVVELL.TLTLP.....LMRALDQLmVNSSHSEPLRVQVTvrnARTYQIHY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     299.83|      95|     176|     542|     645|       2
---------------------------------------------------------------------------
  542-  645 (149.12/127.63)	VSRVArLRCNAAIEEIESKVKMLGFEPLNPRAwKVDFRKIFPSNVLRFAFFSHHL..WERNWIVAATssmdGDSWWVVQLRPtvlAKGP...SLLDASGRGQ...SVLRSAQ
  721-  823 (150.71/101.51)	VFRVA.MPVNAKRKSFFKDTIRLAFHGIDPRK.KCAIMVAYGSLANPTGAFGHLIsnWDRSLVFQKT....GGGFAIRLLAP...AGHPvivSLIESLQRLEcvlSILESLQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     149.00|      45|     201|      14|      63|       3
---------------------------------------------------------------------------
   14-   63 (75.44/55.00)	LRHGPGNNYSQDGQSYPRGETVRfNSQNDPPNVN...GVEKNASHnraiEIPP
  220-  267 (73.56/41.15)	LSKGKVESMSNLGYKPPRRLTVR.GTLKRLQKINrliGVRLVARD....EIPP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     108.89|      32|      59|     403|     437|       4
---------------------------------------------------------------------------
  403-  437 (56.72/43.55)	YRGQRRSNCESSGLPVLGCRWMRdgNEvPCD...DIDF
  464-  498 (52.18/29.71)	YRNIGHSSLFSSGLLSLRARLTR..TE.PGDcllDVQL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      35.49|      11|     426|     443|     455|       5
---------------------------------------------------------------------------
  443-  455 (15.28/16.20)	SMESLLRsiIALH
  872-  882 (20.21/12.97)	SLESLFR..LRLH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.07|      16|     162|     669|     684|       9
---------------------------------------------------------------------------
  669-  684 (27.99/18.36)	SLSGILAIHSNARYLS
  833-  848 (29.08/19.38)	SLSSISFIYGPERDLS
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP21363 with Med14 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) AEMQVNPHEYHPSPVPTSGKYPGNQPPDNTRKKLRM
2) SRNGSGHKPTDRAASPGTSNITALSVSARATGNTDGTKSAHQDSLATLPNNKSTQSQANPATQKEDVIMID
3) VMDDASIGGLRHGPGNNYSQDGQSYPRGETVRFNSQNDPPNVNGVEKNASHNRAIEIPPVNHALRGNKGPPDLPH
110
1037
5
145
1107
79










Molecular Recognition Features






MoRF SequenceStartStop




NANANA