<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP21361

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMDFPGGSITNIRVIDGFSQIYWRIYTEEPNSANTPGESPANGYTILKHLSRLKDLELQIRDRDCLVSSYPRRLCLWVFSATPGFESLLPLSANEAKDDSSRLAIGSATMKASSSGNVSSLDLVKNLSTEPQNAPGTTGPQRQNALTPYATIYASFISAVSGAVSLQLVRQRNAIPLGSRTLFTAVERDSYDCFVKNDPLSASSLITLQIQLTSVGKLTVALQTVSQAGLRRLLAPEDDPAGIHDIPPGTDLWLSPSGSISRLVAANLSRLNAASPYPSSAGGPGNDKSSMATRKQWKVNVLWWLANFGLPVDEIDEEAWVEVEVWEPFYSRLAGEIGRSNDESSSTLPLKRILWPAIYCFKRTKSASSDSYGELDSVGPVLGDPLDFAEKWRVTEKPTFIEASPKPSSVHQEPQARDQDALSPDMPNLPEGIESLSRASQYPELQTASLVYPTPPDGAAATGLNPTVPSDVFPDDLEQGSSFMQSSRQNYHGQLNKDRTGAEVISFGPSAGLVVGSGLYDTNDDDDLFGDINERDFGSKGLTDADFSFFDDPDFDHVGGGGGEQEDPIHAMSDFMDTDEPELQPTVDEQASPEQTPAMDIDSSRISPVVEAADLQQEKAVPEAKTPVSSPRDGKPRTISPPLSPVEVKKILFPEPHIGSQHLVKQGQMPGYYNAVAFKQNMSLWDRKYSAEGKFGFTFRGREGPKGADAATSDIPTIGLPRRSGKLKSSTSKEPDSQASPTSGMQASSSDTDSSSDASVESDESGSESGLSPATSSTRKRKRTRSNSGTSLALSQDKAFVRADQETTPQRPEDSVFLGNFLSTFSDWSMAGYFSLAQNQVSPVLIRKDIQVQIAQLLVDQVTQSSLDHKIDGNLGLSDYDDEAYSLQTQLGDAAFVGGMERLDLNGFVSLQDASTLSPPTSNGPNPRQSSQRKEAGKGTILKIPPPHLRVCRGKDFLETLPPAISFWETFGLEPAHGQKDIFAYCIHPHFAAEAADAFLERLGLVYSGCNLGSHTRGERSNFFDRGLGSWDISPSEDSRYFEVMQSLKTICGVLGSAFLNTPPSKDSNLVVYIVNPFTHAAALVDICSAFWSLFQKYIADADKQQARQLNELVLQIIPIDFVTATGSLVVPPQADYLNLALEVYSRCPPKSTQPSLINCAPPVLLAEPLPRSIGFKLSSEGSSPLQEGKCLHIACSRSLDQRWISVAWSDNFGALQRNMSYCLRFRNSLMTRPLVEVRSEIWKATRDIMDRIQARWRVVIVNTDPVDQEEVDTWSNFADQYGKARSITLDLVILSANTTPDLYLEPPFLPVPLSVFNQQSSSTPVATPNLGGSVSSPDQLGNAPTPPGGLGVPANASTPTDALPEIESESLITDIYDETWGVVLSHRLNSSLHQTEYRPALASGYLLRRKGSTDGDGLYTMSVNILHARRSPSSYDTLLREILGMYRDLATLARARGTRTVQQGTLPWHVATAVKAQTMLSYAL
Length1484
PositionKinase
OrganismAspergillus sclerotioniger CBS 115572
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Aspergillus.
Aromaticity0.08
Grand average of hydropathy-0.365
Instability index53.91
Isoelectric point4.95
Molecular weight161509.57
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



ECO:0000256	RuleBase:RU364134

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP21361
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     305.36|      94|     127|    1205|    1303|       1
---------------------------------------------------------------------------
 1205- 1303 (154.05/97.42)	SVAWSDNFG.ALQRNMSYCLRFRNSLMTRPLVEVRSEiwKATRDIMDRiqaRWRVVIVNTDPVDQEEVDTWSNFADQYGKARS........ITLDLVILSANTTPDLY
 1333- 1435 (151.31/83.56)	SVSSPDQLGnAPTPPGGLGVPANASTPTDALPEIESE..SLITDIYDE...TWGVVLSHRLNSSLHQTEYRPALASGYLLRRKgstdgdglYTMSVNILHARRSPSSY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     442.64|     119|     131|     372|     500|       2
---------------------------------------------------------------------------
  372-  482 (170.47/104.41)	.............................................G.ELDSVGP....VLGDPL................DFAEKWRVTEKPTFIEASPKPSSVHQEPQARDQDALSPDMP..NLPEGIESL.S..RASQYPELQTAslvyPT.....PPDGAAATGLNPTVPSD..VF.PDDLEQGSSF
  483-  620 (129.91/84.30)	MQSSRQnyhgqlNKDRTG............................aEVISFGPsaglVVGSGLydtnddddlfgdinerDFGSKGLTDADFSFFD.DP............DFDHVGGGGG..EQEDPIHAM.SdfMDTDEPELQ......PTvdeqaSPEQTPAMDIDSSRISP..VVeAADLQQEKAV
  627-  766 (142.26/80.16)	VSSPRD......GKPRTIspplspvevkkilfpephigsqhlvkqG.QM....P....GYYNAV................AFKQNMSLWDR.KYSAEGKFGFTFRGREGPKGADAATSDIPtiGLPRRSGKLkS..STSKEPDSQAS...........PTSGMQASSSDTDSSSDasVE.SD..ESGS..
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     227.12|      77|     788|      88|     165|       4
---------------------------------------------------------------------------
   88-  165 (123.11/63.57)	LPLSANEAKDDSSRLAIGSATM.....KASSSGNVSSLDlVKNLSTEPQNAPG.TTGPQRQNA.....L...TPYATI..YASFISAVSGAVSL
  874-  966 (104.00/49.85)	LGLSDYDDEAYSLQTQLGDAAFvggmeRLDLNGFVSLQD.ASTLSPPTSNGPNpRQSSQRKEAgkgtiLkipPPHLRVcrGKDFLETLPPAISF
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP21361 with Med13 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) ELQTASLVYPTPPDGAAATGLNPTVPSDVFPDDLEQGSSFMQSSRQNYHGQLNKDRTGAEV
2) FGFTFRGREGPKGADAATSDIPTIGLPRRSGKLKSSTSKEPDSQASPTSGMQASSSDTDSSSDASVESDESGSESGLSPATSSTRKRKRTRSNSGTSLALSQDKAFVRADQETTPQRPEDSV
3) FIEASPKPSSVHQEPQARDQDALSPDMPNLPEGIESLSRAS
4) PVATPNLGGSVSSPDQLGNAPTPPGGLGVPANASTPTDALP
5) SFFDDPDFDHVGGGGGEQEDPIHAMSDFMDTDEPELQPTVDEQASPEQTPAMDIDSSRISPVVEAADLQQEKAVPEAKTPVSSPRDGKPRTISPPLSPVEVKKIL
443
694
399
1324
547
503
815
439
1364
651










Molecular Recognition Features






MoRF SequenceStartStop




1) IYWRIY
2) NERDFG
3) VKKIL
20
532
647
25
537
651