<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP21360

Description Mediator of RNA polymerase II transcription subunit 12
SequenceMIPHPSAGVQPWGRSVRALNNGSGRVDVAQAMGQPDPQLEKLSMPAPQPLPRQPAVIDLTTGASDSQDREPPAKRLKLEVPSGSGAADGSPAPGSGGELRSTPGTAGSKPQPLSWRGRPVWSFQALISETTGTAETKEDDTASQGRNHASPPPLPLVPWKYTPQESSESDSAKTGELPAAKEVQTTPYHIVIPSDAPKVKGERVADFSPWTGNHPEDILNEHTAKQGHYDRTQVSQNETNTARPSLYAQLKHRSGLQMLSSVFAAALEKRQNHNTVTAPSSFKPPPRVTLTDNKREAWLRDLANPSVPLRKLSRTIPHGIRGKVLLDQCLGKCIPVPRAVWLARCVGANEIRAFKRKGTSGALALGLETKWVRDWTSTVQQFLESVVSSCGTPDWKMKMTYAVSLTSRLFFERLLDHDQYLAWFLLSLEAAPLNTVPVWLLMLGIYWSNIMRYRKRGRRLAEVLLEKLRQIKLPGQHTALEPLVERLSRCIRRMVLEHTSSVILPNSWDKYKDLISSCLNLEEMPDKTMLQNLAERNVRVQLPKIHQKTAQRLPQQHVIHLFDTVRSTHDVSSTSSACLNAVEDKASLVSKLLEWAATPFRHGFRRVYISVRLLRKWKMSGVDVDTHILAFLANVQVANQLNMDNVYHIIAELVRSQTFSVGKYLQWLMAKGVTNDPSASPHETMSNDVRLLLQLPLARLPEYVRSLRNTLLNRAGIPPSQEESTIAAIKASIAQQLPKIFGAQTDDAMLADLSLSDLTWAVKSEIGLWIRRGVTGHFREPTRKYAHIPLLADSGTSALTAHEFYNLRNVLESFGDISMLADVLKQATTSGDSIVLASVADTVNYHFDSLCVIGAATDLFKGLVESYARLKRIGLPGLDLIFSLIELGLRMPSEFNTVALLRQDLSRIEGKSALAAPSPLSDHIPMTSGGVDSSFQEKLDQILFSGGGLDESSLDSVFTSLTRALGNHGQDKLSANDICRYLAYLRSFHPKRFDAMLVRWVCGLLKSPSRSVMTRILPPLIGVGCVTIHAFVMLVRKLLQSERVASVIPNVADLRLNLLELLVPPEPSQSRYVDMVTYRFYLAQQEFLDKHPEQCLEIIRDAVPLHDTERPEAGGPSQTDLSNCAVILLRTLLTQKPERMVQSCMQKFIGQHPASTAILQKALDSLLGFDPQSTPDMSEAERVISINNDFSLPICQLKLQILFNAEAGSQVDNGIVDVMFKAAMADARSNRDHWYGLVSLMSLDAVRQIRERAERGFFSVPMHDESTSDSSVADKSGSIETARLYLTIIEKLAYSIPEVGAQSVASALVEKMELLLQKFVSMQPNSTGASDAGQTAQARSNFERSLAFWFSALLRLIVIHRAAFNTPSLAPRPTGLQEQARLLTSIFCISLARLPDRVIRLYPSANYFPHPVQSENYRPCPGILLQTHALDVAAALIDTFPDEARHQCARFLREKCPPFLQFQNDPRFLYLLGPIVDTSNLNPTVPASLPSPAAGASTPTPTANLPGGAAIPQQAISSAPSGLPAGLSEGVNCIASHLRLQYRGRVLGAYPVRPWELLEDAAPIVGMNDTAVSLKYFDARRVRA
Length1584
PositionKinase
OrganismAspergillus heteromorphus CBS 117.55
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Aspergillus.
Aromaticity0.07
Grand average of hydropathy-0.182
Instability index48.49
Isoelectric point8.83
Molecular weight174810.44
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.


Component of the srb8-11 complex. The srb8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The srb8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



ECO:0000256	ARBA:ARBA00002895
ECO:0000256	ARBA:ARBA00003744

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP21360
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     116.05|      46|      91|    1172|    1219|       1
---------------------------------------------------------------------------
 1172- 1210 (46.82/34.17)	......................................................QSTPDMSEAERVISINN.DFSLPICQlKLQILFnAEAGSQ
 1211- 1302 (47.91/26.40)	VDNGIVDVMfkaamadarsnrdhwyglvslmsldavrqireraergffsvpmhdESTSDSSVADKSGSIETaRLYLTIIE.KLAYSI.PEVGAQ
 1304- 1342 (21.32/ 7.33)	VASALVEKM.................................elllqkfvsmqpNST.GASDAGQTAQARS.NF....................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     219.26|      74|      96|     340|     435|       3
---------------------------------------------------------------------------
  340-  422 (110.66/133.66)	VW....................LARcVGANEIRAFKRKGTSGALAlGLETKWVRDWTSTVQQFLESVVsscgTPD.WKmkmTYAVSLTSRLFFERLLDHD..QYLA
  438-  534 (108.60/72.22)	VWllmlgiywsnimryrkrgrrLAE.VLLEKLRQIKLPGQHTALE.PLVERLSRCIRRMVLEHTSSVI....LPNsWD...KYKDLISSCLNLEEMPDKTmlQNLA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     184.88|      59|      97|     977|    1043|       4
---------------------------------------------------------------------------
  977- 1043 (97.14/60.59)	DICRYLAYL..RSFHPKRFDAML..VRWVCGlLKSPSRsvmtrilPPLIGVGCVTI.HAFVMLVRKLL..QSER
 1074- 1139 (87.74/41.83)	DMVTYRFYLaqQEFLDKHPEQCLeiIRDAVP.LHDTER.......PEAGGPSQTDLsNCAVILLRTLLtqKPER
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     173.46|      53|      98|     649|     711|       5
---------------------------------------------------------------------------
  655-  707 (94.38/77.24)	RSQTFSVGKYLQWL.MAKGVTNDPSASPHET.MSNDVRLL...LQLPLARLPEYVRSL
 1344- 1401 (79.08/43.21)	RSLAFWFSALLRLIvIHRAAFNTPSLAPRPTgLQEQARLLtsiFCISLARLPDRVIRL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     172.17|      49|     122|      83|     132|       6
---------------------------------------------------------------------------
   22-   54 (33.40/12.62)	............................GSGRVDvaqamGQPDP...................Q...L..EKLSMPA.....PQPLP.R.QP....
   55-  123 (80.73/39.65)	AVIDLTTGasdsqdreppakrlklevpsGSGAAD.....GSPAP...................G...SGGELRSTPGTAGSKPQPLSWRGRPVWSF
  125-  207 (58.04/29.37)	ALISETTG........taetkeddtasqGRNHAS.....PPPLPlvpwkytpqessesdsaktGelpAAKEVQTTPYHIVIPSDAPKVKGERVADF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      92.97|      31|     172|     719|     757|       7
---------------------------------------------------------------------------
  719-  757 (38.97/50.70)	PSqEESTIAAIKasiaQQLPKIFGaqtDDAMLADLSLSD
  892-  922 (54.00/38.91)	PS.EFNTVALLR....QDLSRIEG...KSALAAPSPLSD
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP21360 with Med12 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) MIPHPSAGVQPWGRSVRALNNGSGRVDVAQAMGQPDPQLEKLSMPAPQPLPRQPAVIDLTTGASDSQDREPPAKRLKLEVPSGSGAADGSPAPGSGGELRSTPGTAGSKPQPLSWRGRPVWS
2) QALISETTGTAETKEDDTASQGRNHASPPPLPLVPWKYTPQESSESDSAKTGELPAAKEVQTTPYHIVIPSDAPKVKGERVADFSPWTGNHPEDILNEHTAKQGHYDRTQVSQNETNTARPSLYAQL
1
124
122
250










Molecular Recognition Features






MoRF SequenceStartStop




1) FQALI
2) LVPWKYTP
3) REPPAKRLKLEVP
123
156
69
127
163
81