<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP21358

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMPGVVMDDANTGGHRHGSGNHDSQHGIYSVGEAIRLNGITDSENGSLSVDGVDRNTGHHGAVGLTSINRMSWGLMEPPELPHIMQGFFPFSKLVRRSVQQCWNDLSDLITELAEIRVNSHELHSLPIPANGKSTGNQSSENIQKKVRILEFSHAKRAEFIKLLVLAQWSRQAADVSKLIDIQNFIRTHHQAYMGALQCIGDMKRDLVQAQVANPDLNTALEVLSKGRVASMSDLGYRPPKPLKARGTLRKLQKLNRIIGVRLAVQEEIPCSFQTYRVHDGRVTFIVPGEFELDLSVGEEDEASQFFFVDIHFLFFPSPPVPDGRILNELERTINDVLQNNGLVGCFNLLHGLVLTNKVSILFKQAMELARGPWTDVLRVELLHRTLVIQYWTPKPGAKSWLEIGIKRGGPGSDSGRVGLPFLGLRWIRDGEEVPCEDINFDEEYLSMERVLRSTIALHVSQILSSAYSNIRHSSLFSAGLLSLRAQLNSTEPGDCLLDVQLTKTRYLRVSVEPMSGMSILSVTSNALERFDGDRNPDKSFVDDIVARVARLRCSAAIEEIESNLKMLGFEPLNSRAWKSDVRKIFPPNTLRFTFFWHHLWKRNWVVAATSSMDGDSWWVVQLGTTVLAKAHAVLDANLHGQLVFRTTQIVSHTFFPASQHNISYTSLADLGHCLSGILAIHSNAHFLEDLQSIEFYPPLHKLKIEPNLRVPDIFIRYDASNLPTAFQLAMPVRAKRKSHIKDTVRLAFHGIDPCRKVAIMVAYGSLASSASAFGAPVSNWDRSLVFQRKGSGFALRFLAPAGHPIIIKLIESLQRLECVLSILESLQRKKIGVRTFSLSNISFTYGPERDFSASLNIDLSMIQSLMDLSPIGLASRTESIFNLRLGIQFGHNSPHRRIQESLASSLNHVATDAGLENVVEILSLTLPLMRALDQLMTNSSSNERLKVQVTVRNARSYQIHYPDENLKFQLVAASHLNRFVWVLKDVNIQGNMINNGNIKNKLQETLYNSRGDGWRGLGNGLVAEAGSIENLLREIERRFGTSQGRKTPEAKVGKSNNPRLSASSGGPGHTGSIEDVRSSSLATAPGTRDTQSGANTGTQKEDIIMID
Length1107
PositionTail
OrganismAspergillus heteromorphus CBS 117.55
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Aspergillus.
Aromaticity0.07
Grand average of hydropathy-0.194
Instability index43.04
Isoelectric point8.77
Molecular weight123051.02
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	ARBA:ARBA00003669
ECO:0000256	RuleBase:RU365082

GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP21358
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      99.63|      31|      39|     625|     656|       1
---------------------------------------------------------------------------
  625-  656 (48.87/40.77)	TVLAKAHAVLDANL..HGQLVFrTTQIVSHTFFP
  665-  697 (50.76/36.86)	TSLADLGHCLSGILaiHSNAHF.LEDLQSIEFYP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     130.04|      35|     147|     872|     920|       2
---------------------------------------------------------------------------
  834-  865 (34.99/ 9.97)	....RTFSLSN........ISFTYGPErdfSASLNIDLSMIQSL
  872-  906 (59.94/49.29)	GLASRTESIFNL......RLGIQFGHN...SPHRRIQESLASSL
 1020- 1055 (35.11/12.71)	GLVAEAGSIENLlreierRFGTSQGRK...TPEAKVGKS.....
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     467.43|     138|     148|     154|     299|       3
---------------------------------------------------------------------------
  154-  252 (141.83/92.00)	..........................................................................AKRAEFIK..LLVL.AQW.SRQAADVSKLIDIQ....NFIRTHHQAYMG.ALQCIGDMKR...............DLVQAQVANPDLNTALEVLSKG......RVASMSD...LGYRPPKPLKAR...GTLRKLQ
  253-  402 (184.92/147.00)	KLNRiiGVRLAVQEEIPCSFQTYR.VHDGRVtfiVPGEfelDLSVGEE........................deASQFFFVD..IHFL.FFP.SPPVPDGRILNELE....RTINDVLQN.NG.LVGCF.NLLH...............GLVLTNKVSILFKQAME.LARGpwtdvlRVELLHRtlvIQYWTPKP.......GAKSWLE
  404-  584 (140.68/93.49)	GIKR..GGPGSDSGRVGLPFLGLRwIRDGEE...VPCE...DINFDEEylsmervlrstialhvsqilssaysnIRHSSLFSagLLSLrAQLnSTEPGDC..LLDVQltktRYLRVSVEPMSGmSILSVTSNALerfdgdrnpdksfvdDIV.ARVARLRCSAAIEEIE..........SNLKM...LGF...EPLNSRawkSDVRKI.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      28.64|       8|      42|       8|      17|       5
---------------------------------------------------------------------------
    8-   17 ( 9.72/15.01)	DANTgGHrHG
   53-   60 (18.92/11.23)	DRNT.GH.HG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      80.21|      21|     375|     585|     605|       6
---------------------------------------------------------------------------
  585-  605 (45.53/23.49)	FPPNTLRFTFF.WHHLWKRNWV
  961-  982 (34.68/16.49)	YPDENLKFQLVaASHLNRFVWV
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP21358 with Med14 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) ERRFGTSQGRKTPEAKVGKSNNPRLSASSGGPGHTGSIEDVRSSSLATAPGTRDTQSGANTGTQKEDIIMID
1036
1107










Molecular Recognition Features






MoRF SequenceStartStop




1) KEDIIMID
1100
1107