<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP21356

Description Mediator of RNA polymerase II transcription subunit 19
SequenceMTTLYSHQHHHPPTPALDQPTPQSPPPFYMSSNHAPSNNHSDKYHHHHPSALSPPNSSVTSSFSGGPRSLHPSNTIPTPASSAANTVPATFEDNEADMMMMDEGSDTGSNKRRRTSSSSYDRTSQTMPPALRHRGDLPDGIPPPIPTEQELLSQPDVSPYHLVCSNRLFPFHPFPLHSCCFPGHFRDDLLDLYGLRDIANSVARKNPTTGAKNKLRKSFKGFLGGLAGKNVVVTKASQTEVEPGGEAGSGGGDYFATLLGFPDEEWRNLQVIGKEISKGIDMGKLRKGLSMGRGDIPGFDPSVLGLDEESQRRKTPYVGSTTPAIGAAVGTPGHANGSTPGGPSPAGDDRPKRAKRRRDDGGDDDNGVNGSVGGVAGGRNHGPGPGVGPGAIVDGAVWDGEKRKKKRKKVTNTPLNI
Length417
PositionHead
OrganismTuber magnatum (white Piedmont truffle)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Pezizomycetes> Pezizales> Tuberaceae> Tuber.
Aromaticity0.06
Grand average of hydropathy-0.782
Instability index54.38
Isoelectric point8.82
Molecular weight44307.67
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP21356
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     145.95|      32|      35|       7|      38|       1
---------------------------------------------------------------------------
    7-   29 (43.53/18.01)	..........................HQHH.HP....PTPALDQPT..PQSPPPFY
   30-   58 (40.64/16.33)	MSSNHA..PSN..........nhsdkYHHH.HP......SAL........SPPNSS
   59-   92 (30.25/10.26)	VTSSFSggPRS...................lHPsntiPTPA.SSAA..NTVPATFE
   98-  143 (31.53/11.01)	MMMMDE..GSDtgsnkrrrtssssydRTSQ.TM....P.PALRHRGdlPDGIPP..
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     292.84|      66|      67|     260|     326|       2
---------------------------------------------------------------------------
  194-  253 (81.89/42.27)	......GLRD..IAN.SVARKNPTTGAK.NKLRKSFKGFL..GGLAGKNV.VV..T..KASQTEVEPGGEAGSGGGD
  254-  324 (104.75/60.39)	YFatllGFPDEEWRNLQVIGKEISKGIDmGKLRKGLSMGR..GDIPGFDPSVL..G..LDEESQRRKTPYVGSTTPA
  325-  346 (32.21/11.78)	IG.aavGTPGH...........................AN..GSTPG.GPS........................PA
  347-  414 (73.99/37.42)	.G...dDRPKRAKRRRDDGGDD.DNGVN.GSV.GGVAGGRnhGPGPGVGPGAIvdGavWDGEKRKKKRKKV.TNTP.
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP21356 with Med19 domain of Kingdom Fungi
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