<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP21343

Description Mediator of RNA polymerase II transcription subunit 16
SequenceMENGFGVDDLFQDETVPRLSSRRRVDARLDELRLSGCNSKIAWSKVGSIAIINSAGTGVETRHLACNPEDGQWKLSDAYPIANVSRYHENQRLVHVTWNSPGAELAVVDVLGRVSFYTVFLAVNHLTATRSQILDQDDDLSALVGFWWLPPEKPYALYRPAARQEDRNFRYQALSFKPFGPFHPIANKVAAIGVTRGGTVKMWYQDGQGRYQEVTAELEGFASLDDLFSHASISCSKDHSAVLAAYTLSKQLRVYRIVINWPQPNQPNQPHTVLPNPPTLVIKHLKIEDCACPADSSTHDVSRAQLTHLETLAPNPAPPDIRSSPGVLAVFANKKADGETFSVICRWSLKETPCTLHPSFDQMGVRRTSVSSPTISELYRMDDVVMDKCIIGVSQVTSGTVIALAFSDGSLELRDRYVILPFSTAREYCSTNKNVVMNMMQAGFAFPPEKPCINLALSPNNAVAIRLGPDNDTGLIVMEYMNGPMEQNDNLEIACVALAHQHAYSCNNLINNDDLLLVAQKYRNPTFNNTFLSEAHRALNLKMDFATESLNERLFRNPLLQRCLSLQNSLDFRGERVNKRLSGKLAWATLHLRVASVAFALTFNNPQRQGQGGSAGAASGSGSTSSDIDLRPEALQTLLGLVRWLMDIMSLTISDLFELSKATKNRTSDLAYVRQKVLSGNSPALFLALSSAPRALLRYNCRSLRGLETTAGKHLSPTLSTATDEETKATFRSLKVPIESCAVKISQFERIMTDIDGTIRAAYHNIPEAERAQAEKLLFVNNEIPPIFRAAVERLLNTTLPNLRNDLDIAKLFWHDVTWLGFHDDVASREYRRRNRIDAIRKVVLPKDDDSGGAGGGKVRLRRCTRCCAVVEDIVPNKSPSHWFGSMQRMCFCGTLWMHIS
Length901
PositionTail
OrganismTuber magnatum (white Piedmont truffle)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Pezizomycetes> Pezizales> Tuberaceae> Tuber.
Aromaticity0.08
Grand average of hydropathy-0.237
Instability index43.45
Isoelectric point8.27
Molecular weight100221.05
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP21343
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      83.74|      24|     156|     514|     539|       1
---------------------------------------------------------------------------
  475-  498 (42.72/21.59)	LIVMEYMNGPMEQNDNLEIACVAL
  516-  539 (41.01/21.55)	LLVAQKYRNPTFNNTFLSEAHRAL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      38.04|      12|      28|     702|     713|       4
---------------------------------------------------------------------------
  702-  713 (20.67/10.09)	RSLR.GLETTAGK
  732-  744 (17.37/ 7.54)	RSLKvPIESCAVK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     104.73|      27|     156|     224|     253|       5
---------------------------------------------------------------------------
  224-  250 (44.61/29.88)	LDD.LFSHASISCSKDHSAVLAAYTLSK
  381-  408 (37.33/22.83)	MDDvVMDKCIIGVSQVTSGTVIALAFSD
  420-  437 (22.79/13.05)	LP...FSTAREYCSTNKNVVM.......
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      39.07|       9|     295|     145|     154|       6
---------------------------------------------------------------------------
  145-  154 (18.06/14.00)	GFwWLPPEKP
  443-  451 (21.02/ 9.88)	GF.AFPPEKP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP21343 with Med16 domain of Kingdom Fungi
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