<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP21336

Description Uncharacterized protein
SequenceMSNPQPWARPFQQHAQARPQPWGNQPGQDAQNSLARSSRLDIPNAIRALPPARQPPPDPFFQQPHPQTVTEKPLIIDLTDSNPSHSQRSLINSPKMDGVPYNGALCSRSSIQNSRTRKRLKFAPQACPPASPQFIQPSKVYQGAKNSLTPPALSRGNNSSRQKQIQPQPSKSDFSKPNPRRDNKPKPYLLEAPPGALMFPGLKCSDFFPWRGNHPEDHVTDTQARNGQYDKLYAVKGNNEQASARSSLVPSLKGKSALPSLSSLFLTVLDKRQKYNRLTTPPTFKPPPRVTLPDMRREAWLRDLASPLVPLRRLSRTIPHGLKGPILLDQCAAKSIPTARAVWFARCVGANELRGLKRKGVGSFAVGSETKWLKEWTSQVVRFLERTISECGSSDLWKQKMVYAVRLSAHLFSENLLDRTLFLEWYLSYLETCSLDMLPIAYLMLSIYWDELLKTRRLGRRLAEALLGRAETILAAEDRESYAPLMQKLSILLTDILFSHKESLIVSNSWESYQSILEACVDMRCPVVRSCLRNISQRNKNLLSPMQTKQNGSVSSGQRKLINMLDSIAMPYNINEIWEKCCSLEVEEDQLVRCLCQWATTSLRVGKHRIYIVAGLLGCARQSGISVQDHMKCFLEGFGSNVKGSKDDVYLLVSELVRSKTFSIALYMKWLISRGILSEYTITQESPCHIRLLAEVSVISAPNHIRNLRSILLSDHGFSVEEEARSLEVSKQILSSKMPGVFYGDSRAGGTVEKFTPEELAYFGGLNRVVMYELGLWIRENVRKHVVKGAPVGRDNWRDLSVEVGITAVRTEEFVMMRQLLEMFKDFHILAEVVRMVTSSDSSTTLSSAADTVSYNIEVFSSLGAVKDNLQLLYDRYKKLQMRRTLEKYVLVSLVDLASFQEAQADIRRELETELANYDKRFPRASVAYSPVSENMGDMFEHGTADSNEEIDRLLRNGATIDKHNLSRLFETIVSRMETSFDDRESVGVLSSSAAYLVKLRQFDPLVFDELMCGWVTRLLQSSSRPPLLQTLSVLVAGSCLQLDVIVQATLSVLRPQAKISNPATGEIAAQTLDILVNDGTNGLSLSPLELYSLKRKRKLFALKFVDKFVQLIRQSIQICAVASNPDTKNRVRGLILSPPVLEFLRGLATAQPDTLISDIVEPLSKTGETSLLRWLRVLIDRLLDDQENGGLVAVAYIDPDNTELDPEVQVAHLIQYANDFSIGLCQLKMRIIFDAENKNTSSFRPSGDHTGGSENPLMKPFFQGIASTFKDRVTIWTDLVSVLNQECAHQVFLTHIRGYAEELVLNSPTFPPVRLCLGPLEPSLAEGRESGETLARALLSVIEATAYSIPKQGIASIATLLVDKLNMIIQSITLQEDELEKAEHATVPEVSWNDSLTESRCWYPTNTYSIDLTEDTRLQIRRFAKAKRPTARMTYLIGGGEASGSILKATQRGKLVDFPVKPWERLAEPSPVIGENDTSISLTLFCTRKIRCARGDGGY
Length1500
PositionKinase
OrganismTuber magnatum (white Piedmont truffle)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Pezizomycetes> Pezizales> Tuberaceae> Tuber.
Aromaticity0.07
Grand average of hydropathy-0.263
Instability index49.56
Isoelectric point8.88
Molecular weight168063.93
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.


Component of the srb8-11 complex. The srb8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The srb8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP21336
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     546.77|     180|     186|     871|    1056|       1
---------------------------------------------------------------------------
  804-  868 (44.29/21.58)	...............................................................................................................................VGIT..AVRTEEFVMMRQLLEMFKDFHILAEVVRMVTSSDSSTTLSS.....AADT.VSYNIEVFS...SLGAVKD
  871- 1056 (269.97/211.04)	QLLYDRYKKLQMrRTLEkyVLV....SLVDLASFQEAQADIRRELeTELANYDK..RFPRASVAYSPVSENmGDMFE..HGTADSnEEIDRLLRNGATIDKHNL.SRLFETIVSRMETSFDD..RESVGVL..SSSAAYLVKLRQFDPLVFDELMCGWVTRLLQSSSRPPLLQTLSVLVAGSC.LQLDVIVQA...TLSVLRP
 1059- 1246 (232.50/159.23)	KISNPATGEIAA.QTLD..ILVndgtNGLSLSPLELYSLKRKRKL.FALKFVDKfvQLIRQSIQICAVASN.PDTKNrvRGLILS.PPVLEFLRGLATAQPDTLiSDIVEPLSKTGETSLLRwlRVLIDRLldDQENGGLVAVAYIDP...DN......TELDPEVQVAHLIQYANDFSIGLCqLKMRIIFDAenkNTSSFRP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      78.33|      21|     187|      21|      41|       2
---------------------------------------------------------------------------
   21-   41 (40.21/21.18)	PW.GNQPGQDAQNSLARSSRLD
  209-  230 (38.12/19.73)	PWrGNHPEDHVTDTQARNGQYD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     176.52|      37|      37|     396|     432|       3
---------------------------------------------------------------------------
  357-  393 (40.66/21.98)	..KRKGVgsFAVGSETKWLK..EWTSQVVR...FLERTISECGS
  396-  432 (63.78/38.48)	LWKQKMV..YAVRLSAHLFS..ENLLDRTL...FLEWYLSYLET
  435-  472 (43.89/24.28)	LDMLPIA..Y.LMLSIY.WD..ELLKTRRLgrrLAEALLGRAET
  487-  518 (28.18/13.07)	...QKL....SILLTDILFShkESLIVSNS...W.ESYQSILE.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     146.94|      37|      41|     101|     137|       4
---------------------------------------------------------------------------
   51-  123 (51.39/27.45)	PARQPPPDPFFQQPhpqtvtekpliidltdsnpshsqrslinspkmdgvpYNGALCSRS....SIQNSRTRKRLKFA
  124-  166 (53.09/28.61)	PQACPPASPQFIQP.................................skvYQGAKNSLTppalSRGNNSSRQK.QIQ
  167-  178 (22.34/ 7.56)	PQ...PSKSDFSKP..............................................................N
  257-  276 (20.12/ 6.04)	.....................................................ALPSLS....SLFLTVLDKRQKYN
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP21336 with Med12 domain of Kingdom Fungi
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