<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP21334

Description Vacuolar-sorting protein SNF7
SequenceMTSRPGPGIHESLQNRGSGVPPRTQAQRRASKPAHTLLHPDCIDPALDDERPAAHHAAHDAACPPPRGRPPLFYTTIAQYPLDFHPHGLPYQPSVNLPVPPRPGLVHLRDAAHQRRILPGGSGVKDAPKSGAPEVIVPPVYFPGGKPADLFPWTGNNAEDNLTETLVKAGVSNKPQIMNESNTARPSLINNLKNKSGLSTLSTLFVAVLEKRQQTGRLQTPNTFKPPPRLTLRDSTREQWLHDLANPNTGLRRLSRTIPHGLTGKVLLEQCLNKNIPLPRALWLAKCVGINELRAHKRKGQAGTVTWGRGWTSSVEQFIDGVIGTIGQGDWKPRITYALQLATHLYKEHLLDDDHFLDWIVDGLGSCPSERLFIWLLIVSVSHYWADVSCCRRRGRRLAESLLNQLDKIYRVEDVNPYLAVLHYLENTVIRLIATIPACLLLPTAWAKYSPLLVQLAERRNHPHVTQAVRRLEQRNSRLLQSSKNLPSASQTPAGRVYRILDSVDYNRPVRIEDLSLDCMEVVADAPRLIDILLRWACSCYREGSHRIYLATRLLRKWAHLGADVYDGILSHFHELTWVATGESSILFKIVAELVRSKTFATGRYLQWLIATGSIGHSTDLSSPTAWALRLITEIPLTGLPEQIRLLRSTLLRGTIHSAEQEQHALCYVEHMISQSLPALFGHCNAATRLNESELDKLSSTVKLELGIWLRQHVAQYAEVNQQ
Length723
PositionKinase
OrganismPyrenophora tritici-repentis
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Dothideomycetes> Pleosporomycetidae> Pleosporales> Pleosporineae> Pleosporaceae> Pyrenophora.
Aromaticity0.07
Grand average of hydropathy-0.292
Instability index48.51
Isoelectric point9.34
Molecular weight80911.85
Publications
PubMed=29685100

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. Component of the srb8-11 complex. The srb8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The srb8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
ECO:0000256	ARBA:ARBA00002895
ECO:0000256	ARBA:ARBA00003744
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP21334
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     309.86|     106|     178|       2|     123|       1
---------------------------------------------------------------------------
   12-   46 (23.57/21.52)	..................................................................................................SLQNRgSGVPPRTQ...AQRRASKPAHTLLHPDCIDPA
   47-  123 (112.37/68.73)	LDDERPAAHHAAHDAACPP...PRGRPP.LF.YT.TIAQYPL..DFHPHGLP....YQPSV.NLPVP.PRP.......GLVHLRdaAHQRRilpGGSG......................................
  129-  227 (102.05/53.55)	........KSGAPEVIVPPvyfPGGKPAdLFpWTgNNAEDNLteTLVKAGVS....NKPQImNESNT.ARP.......SLIN................NLKNK.SGLSTLSTlfvAVLEKRQQTGRLQTPNTFKPP
  230-  303 (71.86/32.73)	LTLRDSTREQWLHDLANPN...TGLR...RL.SR.TI..........PHGLTgkvlLEQCL.NKNIPlPRAlwlakcvGINELR..AHKRK...GQAG......................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     333.96|     115|     174|     314|     447|       2
---------------------------------------------------------------------------
  314-  447 (172.97/146.33)	SVEQFIDgvigtIGQGDWKPRITYALQ..............................LATHLYKEHLLDDDHFLDwIVDGLGSCPseRLFIWLLivsvshYWAdVSCCRRRGRR..LAESLLNQLDKIYrvEDVnpYLAVL.HYLENTVI.....RLIATIPACLL...........................LPTAWA
  449-  628 (160.99/93.63)	YSPLLVQ.....LAERRNHPHVTQAVRrleqrnsrllqssknlpsasqtpagrvyriLDSVDYNRPVRIEDLSLD.CMEVVADAP..RLIDILL......RWA.CSCYREGSHRiyLATRLLRKWAHLG..ADV..YDGILsHFHELTWVatgesSILFKIVAELVrsktfatgrylqwliatgsighstdlsSPTAWA
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP21334 with Med12 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) GLPYQPSVNLPVPPRPGLVHLRDAAHQRRILPGGSGVKDAPKS
2) LTETLVKAGVSNKPQIMNESNTARPSLINNL
3) MTSRPGPGIHESLQNRGSGVPPRTQAQRRASKPAHTLLHPDCIDPALDDERPAAHHAAHDAACPPPRGRP
88
162
1
130
192
70










Molecular Recognition Features






MoRF SequenceStartStop




NANANA