<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP21332

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMHSPRRAHASSPLAGADMTAPGSVNGGYVGKMGAPAANGNGDLPALGMPPPASMLAPAAAANGAHTWPEAGPSSLQKPGAGAASEAAALLLRTERARKKARLRQAEGISREELERELIPETEGLVPLGAVVARLANYGFETFTNLSETLPTLSSAERRAKIFAAALDVRKQLVKLLVLVQWSKSAPELMVARNLIALICGQFGQAQDAADALIEVRNSLPAARIRTADLASAIDVQGSGEYPRLPSALKDAYVQPAPFSDTEALAIVRELDTALCLRLATVEVVPLQMSDYSIADGRASFFVSKLFEARLTLSGADETDRWYLLDVLFDFRITGAGADIFPRRPKKHARATLLAQTDAELTPRSPAAALEGANEPEGSAAERQEGDAASEAGDFRRRDAPLIRAFNFLQSQALEYQLDILNYQAVQLSRVSWAPTLTAGFEPILRQGDPRTLSLAYWRNRAGPSTAPPPKLGQKVLWNPLAGGSISIRVRDRTRATTAGKSALLSRLLCRDVAAVEATPGQELKEQELNVEWKVAAELEQQLDVGCLTIDAQHLDIETVLLAAVSRHAAAAISELRSRVLKSPLRRILTEVRCVSEAQTQHGRPSHVLQLPLHDRLRLLLRLDAISGRLSLERSKESAEADGPVALSAETLARDSATKRLQEASVLVNDDPKLLVEVLMRQRILAILDDLEQKATYLGLPCTRRMPLRPTEYAKLGAQVSLLYVPLVQCPSYYLVLNIGEASIRAGLMCAGTFIEGAMTVMAVHSVEWLDRERLGRAGALGKRKRDMATAGMQAALDLSIEELSMMHRYSVALVCYHQVEQQLRARGLPFVHVGAATSTSSPPMARPSAAAGPSKPSADAAVPSLCLRAESLLGPTRALVKRNVSLRLVDWSDRMRCRVEISVRLRKALGMASRRITVDEATGDSLEFSRETLVLTFSTRIISDCLSRFFAEWNRIARVTMLARDVARAGRSGKGKGRLELRSFDPERVVFAYDHGLTAVIRWQPSLAQMGNSFYALELSSDDETQPNPHRLVAASLQRMLNGMHDGSSSFWPSFIQLLHDTLPVLRVLAPLADTCLTDADCPEPEFRSATWIRLHFFGHFVLDIRFLRNSKVLFSDGALPLAVCAPPDAQQPLAKKEEDAAAAAAPKADLSQPPRAPRSSNLDQATKEDFAALPQIFNPIPRFGDIAGRVVRLVTAPQPSAPAATAGEAPAARDPLAAINLGRAVLCDCADDVARPVLQSLLDQMRQALAAEPSAAA
Length1258
PositionTail
OrganismTilletiopsis washingtonensis
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Ustilaginomycotina> Exobasidiomycetes> Entylomatales> Entylomatales incertae sedis> Tilletiopsis.
Aromaticity0.05
Grand average of hydropathy-0.097
Instability index47.64
Isoelectric point8.44
Molecular weight136165.53
Publications
PubMed=29771364

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP21332
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.53|      16|     233|     270|     287|       1
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  244-  259 (28.67/16.61)	LPSA..LKDAYVQPAPFS
  270-  287 (20.86/18.05)	LDTAlcLRLATVEVVPLQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     543.13|     163|     280|     486|     651|       2
---------------------------------------------------------------------------
  464-  530 (80.26/40.25)	.................................................ST.APPPK..LGQKVL...................WNPL.....................................................................................................aggsiSIRVRD...RTRATTAGKSALLSRLLCRDVAAVEATPGQELKEQELNV
  531-  651 (156.83/96.32)	EWKVA....AELEQQL........DVGCLTIDAQHLDIETVLLAAVSRHAA.AAISE..LRSRVL...................KSPLR.....RILTEVRCVSEAQTQHgrPSHVLQL.PLHD...RLR....LLLRLDAISGRLSLERSKESAEADGpVALSAETL..........................................................................
  656-  805 (157.00/86.77)	....A....TKRLQEA........SV..LVNDDPKLLVEVLM..................RQRILailddleqkatylglpctrRMPLRpteyaKLGAQVSLLYVPLVQC..PSYYLVL.NIGEasiRAG....LMCAGTFIEGAMTV.MAVHSVE............................................wldRERLGRAG..ALGKR..KRDMATAGMQAALDLSIEELSM
  808-  982 (149.05/81.95)	RYSVAlvcyHQVEQQLrarglpfvHVGAATSTSSPPMARPSAAAGPSKPSAdAAVPSlcLRAESL...................LGPTR.....ALVK..RNVS............LRLvDWSD...RMRcrveISVRLRKALGMASRRITVDEATGDS.LEFSRETLvltfstriisdclsrffaewnriarvTMLARD...VARAGRSGKGK..GRLELR....................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      95.93|      21|      21|      34|      54|       3
---------------------------------------------------------------------------
    7-   24 (24.96/ 9.88)	...AHASS..PLAGADMTAPGSV
   34-   54 (40.94/21.46)	APAANGNG..DLPALGMPPPASM
   56-   75 (30.03/13.56)	APAAAANGahTWPEAG...PSSL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.60|      12|      20|     305|     320|       4
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  305-  316 (21.53/16.85)	LFEARLTLSGAD
  327-  338 (23.07/ 7.34)	LFDFRITGAGAD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      63.45|      21|      21|     168|     188|       5
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  168-  188 (33.73/22.36)	VRKQLVKLLV..LVQWSKSAPEL
  190-  212 (29.72/18.72)	VARNLIALICgqFGQAQDAADAL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     160.29|      53|     298|      76|     160|       6
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   76-  133 (74.01/81.79)	QKPGAGAASEAAALLLRTERARKKARLRQAegiSREELerELIPETEGLVP.LGAVVAR
 1137- 1190 (86.28/37.33)	KEEDAAAAAAPKADLSQPPRAPRSSNLDQA...TKEDF..AALPQIFNPIPrFGDIAGR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.51|      15|     766|     433|     449|       8
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  433-  449 (24.86/14.73)	APTLTAGFEPILRqgDP
 1202- 1216 (28.65/11.55)	APAATAGEAPAAR..DP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP21332 with Med14 domain of Kingdom Fungi
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