<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP21330

Description Mediator of RNA polymerase II transcription subunit 17
SequenceMAHGHATSGPRSSAAASTIAIEPPVILSQASRDALQRARRQLWEGDVKSSEPRDDLGDVVERAWLDKEAPAGDRRPLFAKMEKLLAERGGDFSKLHSSQFKRSSTAEQQGDVKRDDNDDDDEHELDLGVAKLGEEGQEKTGDEKQAGGEDAQEEYETSGRDAMTIEEMRQLRSEMLDNLNTARGSLYYSHGLVSLLLNSSKVESGSSGPGGRAGTPSSSAGGVARAGTATSMTGGAQRNAPASQLQLMSNAANLEADLGIEPNVFGASKLQLKKAETEDGDEDDETNEDDEDDDDGNEDLQKELEKQQKQDARIDEADLEDRARDLIECYQAKHDGLASAADILAKGAKALRASSSSEDETKRWAALSEARSGGWGLVPGRPIRVKNGKRELLPDDAMRRRDEAARDAWISYAAPEAATAYQKRALAYYGYSGDGIVFAARPNRTLQVSLVVKDAHGAKPSVWTSKSKASGSADGGEQSEEGIEARLRRAQRELADVELYDALLAECRALSSASLARTTIEDAYSVSLEINPLTDMCFSMVENEDTDTDKVRPADNEQDDAYSPIANVVLSSLRLGLGKKYRQRAGIAKPAKRRAQGKVDDVFRRTAPLLVPVLGLIHYSSFVGKLKTTLDDIVSGRGATYELRTMSGSVYASKVLRSAFEEEDEDEDGGTELEQDALEKVIGAHATIYSASSDEKTAPSRSAVALLTIAYPSRLSLSLPARGVHLPSIDLLSLRDILLDQLSKP
Length745
PositionHead
OrganismAcaromyces ingoldii
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Ustilaginomycotina> Exobasidiomycetes> Exobasidiales> Cryptobasidiaceae> Acaromyces.
Aromaticity0.04
Grand average of hydropathy-0.648
Instability index54.56
Isoelectric point4.85
Molecular weight80560.96
Publications
PubMed=29771364

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364140
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP21330
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     395.80|     157|     172|      69|     240|       1
---------------------------------------------------------------------------
    4-   57 (42.68/14.46)	...........................................................................................GHATSgPRSSAAASTIAIEPPVILSQASRDA..................................LQRARRQLWEGD....VKSSEPRDDLG............
   77-  134 (30.44/30.43)	................................................................................................................................LFAKMEKLLAERGGD...F..SKLhssQFKRSSTAEQQGD....VKRDDNDDDDEHElDLGvaKLGE
  135-  305 (240.47/124.22)	EGQEKTG..DEKQAGGED.AQ...EEY.E......TSGRDAMTIEEMRQLRSEMLDNLNTARGSLYYSHGLVSLLLNsSKVESGSSG..PGGRAGT.PSSSAGGVARAGTATSMTGGAQRNApasqlqLMSNAANLEADLGIEpnvFgaSKL...QLKKAET..EDGDeddeTNEDDEDDDDGNE.DLQ..KELE
  306-  380 (39.37/10.55)	KQQKQDAriDE..ADLEDrARdliECY.QakhdglASAADILA.KGAKALRASSSSEDETKR........WAAL....SEARSGGWGlvPG........................................................................................................
  474-  531 (42.83/12.19)	DGGEQSE..EGIEARLRR.AQ...RELaD......VELYDAL.LAECRALSSASL.....ARTTIEDAYS.VSLEIN......................................................................................................................
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP21330 with Med17 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) ASKLQLKKAETEDGDEDDETNEDDEDDDDGNEDLQKELEKQQKQDARIDEAD
2) MAHGHATSGPRSSAAASTIAIEPPVILSQASRDA
3) NSSKVESGSSGPGGRAGTPSSSAGGVARAGTATSMTGGAQRNAPASQLQLMSNAAN
4) RARRQLWEGDVKSSEPRDDLGDVVERAWLDKEAPAGD
5) RGGDFSKLHSSQFKRSSTAEQQGDVKRDDNDDDDEHELDLGVAKLGEEGQEKTGDEKQAGGEDAQEEYETSGRDAMTIEEMRQLRSEMLD
267
1
198
37
88
318
34
253
73
177










Molecular Recognition Features






MoRF SequenceStartStop




1) AAASTIAIEPPVILSQASRDALQRARRQLWEGDVK
2) EPRDDLGDVVERAWLDKEA
3) LFAKMEKLLAER
4) MAHGHA
14
51
77
1
48
69
88
6