<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP21323

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMPSTPTVHQRAQDHHHSTSFVNAAQHNAAAARQGHAGYAKPSPAQGPLGALSPTISTPSNPSIASGGSVVHNSNGANGRTSKGQIAGPANGGGGGGGAVGNSSGDAGGGIVSGAGVGQAKVNGDDGQDRQGGAIAGPGPSTVQAAAAAAAAASSSKTNQFTLHNGVSEGQDAPQDLSQEVYSILYKTRRRRAWEKSRHIDEVMPTREELDEQVRPPLPNPDEQDRDLIPLSAIAQRLVFYAWQLFANQVEINPSLSPMERRKRMFNDAVEARKQLIKLLVLARWCACAEELHLARDIISFINDHIFQTDSAVASLNETRSILTRARLRSFDVVTAIEVLGAGAPQRVPPLIKESIAPQKQYTDDEALEIIEELNEALTVRLACDEAIPVPMLSYTIDDGRACFVVPSLFEADLTLAGVSIEEALWQLTRVKFDFKITGSGADRFPRQPINQQRQVILYLANAELAPKSIAAVPELEASTEQVPAQTATAAVTVETDVEMHDAEDGIPAEFDKPGDTLPFRKDTPLLRLYNFLQSQALNYQLDILHYQAIQLTKLSWGASLAVHMDHTARPRTLSIRYWNQQGAVRTESGQRGEQQRAWTPAASATLKVSVREVQDSSGKGVTVEGLLDVQDDDEERARNQSLTRLEIPVEWEVDGPATPHLRTKDFTIDNRDLDIEKLLLEAVSRHAHAALLAFRSRIQASSLCAAVGSDQCRLRSHMEHRRPTHALVLPLHERLCLVLHLDALSGQLRLEEAQGSGSTTSLSCTSLASHDRSRQLRDASKRLNDRPGQVVSILQNLRCNVILEDLEQKASLLGLPCTRRLPLRQEDYQQLRAHPGTMLFVHLAPFPTYYLVLRVTDDAIRVALICAHTFMEGVMTSMLIYSLVWLDRSRITRSHALSEEAKTLGKRRHGMNVAISRGNPMSLTEEELAKLYSYSLALVSFNKVEQQLQLKNVPFVHVSPASARSGEIDDCDDVQRSVIDLVPSLALRADMLLGPAHTIVKPNLSLKMKQWWDVSKSRVEISARLRVRAGLSNRRISASGGATLDFDPRTSILTFSTQDVDNCISMFLLEWNRVSKVANLAKELLGCHKIDGWSSGFVPTLDKFDLCSVSFEYAKGLSAEVSWREDLRLLKGGFYSIVFSSSLASKNPHEVMAPTLQRSLSRGNDNEPGFWLGFLKLLQNLLPMLEQVSEIDERCLEDVSSPELEVRSATQLRLVFWEQYVLDIELRRGAKVLFSTTTAPSPALEAKVVVDEDRLKRATAIPNFDRIALDVTKAYCEQAEPSSSESSRIVQRLPAVLALERGILSDCTPATARFVLRMLQEKIVEELTAVEAI
Length1333
PositionTail
OrganismAcaromyces ingoldii
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Ustilaginomycotina> Exobasidiomycetes> Exobasidiales> Cryptobasidiaceae> Acaromyces.
Aromaticity0.06
Grand average of hydropathy-0.246
Instability index51.98
Isoelectric point6.05
Molecular weight146550.50
Publications
PubMed=29771364

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU365082
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP21323
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     190.79|      48|     114|     710|     774|       1
---------------------------------------------------------------------------
  730-  774 (70.66/33.10)	PLH..ERLCLVLH.L..DALSGQLRLEEAQGSGSTTSLSCTSLASHDRSR..............
  782-  834 (53.08/41.58)	RLN..DRPGQVVSiL..QNLRCNVILEDLEQKASLLGLPCT......RR.lplrqedyqqlRAH
  842-  895 (67.05/31.75)	HLApfPTYYLVLR.VtdDAIRVALICAHTFMEGVMTSMLIYSLVWLDRSR.........itRSH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     176.51|      43|      46|      46|      88|       2
---------------------------------------------------------------------------
    2-   41 (36.73/20.80)	............PSTPTVHQRAQDHHHStsfvnaaqhNAAAARQGH.AGYAKP
   46-   88 (76.15/52.51)	GPLGALSPTISTPSNPSIASGGSVVHNS.........NGANGRTSK.GQIAGP
   93-  137 (63.63/42.44)	GGGGGAVGNSSGDAGGGIVSGAGVGQAK........vNGDDGQDRQgGAIAGP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     107.68|      34|      46|     201|     235|       3
---------------------------------------------------------------------------
  201-  235 (52.99/39.07)	EVMPTREELDEQVRpPLPNPDEQDRDLIPLSAIAQ
  250-  283 (54.69/34.89)	EINPSLSPMERRKR.MFNDAVEARKQLIKLLVLAR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     227.12|      73|     182|     897|    1028|       4
---------------------------------------------------------------------------
  901-  985 (102.95/139.94)	AkTLGKRRhgmnvaISRGNPMSLTEEELAKLYSYSLalvsfNKVEQQLQLKNVPFVHVSPASARSGEIDDCDDVQRSVIDLVPSL
 1029- 1101 (124.17/55.52)	A.GLSNRR......ISASGGATLDFDPRTSILTFST.....QDVDNCISMFLLEWNRVSKVANLAKELLGCHKIDGWSSGFVPTL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     139.71|      43|      45|    1127|    1171|       6
---------------------------------------------------------------------------
 1127- 1171 (69.42/50.54)	LRLLKGGFYSIVFSSSLASKNPHEVMAPTLQrsLSRGNDNEPGFW
 1175- 1217 (70.28/44.95)	LKLLQNLLPMLEQVSEIDERCLEDVSSPELE..VRSATQLRLVFW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      97.86|      33|     129|     470|     503|       8
---------------------------------------------------------------------------
  470-  503 (49.31/40.10)	AAVPELEASTEQVpAQTATAAVTVE..TDVEMHDAE
  601-  635 (48.54/33.38)	AASATLKVSVREV.QDSSGKGVTVEglLDVQDDDEE
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP21323 with Med14 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) KSRHIDEVMPTREELDEQVRPPLPNPDEQDR
2) MPSTPTVHQRAQDHHHSTSFVNAAQHNAAAARQGHAGYAKPSPAQGPLGALSPTISTPSNPSIASGGSVVHNSNGANGRTSKGQIAGPANGGGGGGGAVGNSSGDAGGGIVSGAGVGQAKVNGDDGQDRQGGAIAGPGPSTVQAAAAAAAAASSSKTNQFTLHNGVSEGQDAP
195
1
225
173










Molecular Recognition Features






MoRF SequenceStartStop




NANANA