<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP21319

Description Mediator of RNA polymerase II transcription subunit 5
SequenceMADVTSFLDETEDVDALWTLIEVASGAIRHAVEHHLAPVSRLFTGVLSHVAISHQRLTKVSAQKSEAKEAASLALNTSIEAASKANAQEESLILRSIQTALRLSSQPQQETTAIEDPLQGSFQEKKKVAGGRSAMADALRLASASRPSWTSCCSLETIISGKIGGISGTSIPVDPEISNLLHLCVDQLTEMHIKVEAAKMLLGRRIKSKSADTTDDECRSTFYFEILYGATIACATIASTPPTLGGSEAYASVWRSALCGLVPEIIAALEANLEESTSTSARLSRALHALLVGASQVIEGCEVAIAQSEETKKRTGGDEDMEMMLDAFIGSDTPPRQAVRAALLRSLVELKLIEDGAWKSIPGAESVNEDWQLLSLSFQGEVYGTDQSLETLIEQRLSGGDDVQDLFDRIVSDYAAQEVFATTLLRLLEDWTDLEPLSRICRALTASPTALEVLLLYISPSQLLHPFATVLIRDDLAESGDEPSVLASILLFTQAIVQRGLLAGYQVEDLLGTEDHFLSTFTRSSSAVWSLSSLDASEQNLISRWVTALYDSDGISDELIRDSSPQFLLRMAPTLLSQSVHACISGVIDMDTLRGGLSYFLQDLLSFTLPGALRWLVSDIELITSSSLEGPFTPSKALSVRFDVLTTFILAESCPSTVLRLVSSDLQALLSRLALKNKASTDLSSSDNTQARLQQQWMTPELSSLKAKVESEVKTLPLQRTSLWIRAGPHQQGSHHQDLQQHHQQQQQQQRHPQSSSTPQSLLQPPPPPFDSMFGLYQGLLHATRVRGVASVVKRLVKAVDAQHPQGAPMPRPPPPPAAATMAIEKAAAGQGVDSERSMAMQGDTQAQNGGEEEEEREAPRRNRRRAACEVARAVEKLLALRLRRGIKGRERARALLATFLGAKEEGEEKGPVELVFAKALEQGRRVAVS
Length930
PositionTail
OrganismAcaromyces ingoldii
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Ustilaginomycotina> Exobasidiomycetes> Exobasidiales> Cryptobasidiaceae> Acaromyces.
Aromaticity0.05
Grand average of hydropathy-0.144
Instability index61.07
Isoelectric point5.23
Molecular weight101034.38
Publications
PubMed=29771364

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364142
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP21319
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     374.35|      91|     103|     390|     480|       1
---------------------------------------------------------------------------
  310-  374 (46.66/19.74)	.............................ET...KKRTGGDEDMEMML...DAFIgSDTPPrQAVRAALLrslveLKLIEDgaW..KSIP.........GAESV.......NEDWQLL...........
  375-  464 (113.97/57.82)	..........SLSFQG....evygtdqslETL.IEQRLSGGDDVQDLF...DRIV.SDYAA.QEVFATTL.....LRLLED..W..TDLE.........PLSRICRALTASPTALEVLLLYIS.PSQLL
  465-  568 (117.01/59.54)	HPFATVLIRDDLAESGdepsvlasillftQAI.VQRGLLAGYQVEDLLgteDHFL.STFTR.SSSAVWSL.....SSL..D..A..SEQN.........LISRWVTALYDSDGISDELIRDSS.P.QFL
  569-  659 (96.71/48.06)	LRMAPTLLSQ......................sVHACISGVIDMDTL.....RGG.LSYFL.QDLLSFTL.....PGALR...WlvSDIElitssslegPFT.PSKALSVRFDVLTTFILAEScPSTVL
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      85.42|      24|      47|     764|     803|       2
---------------------------------------------------------------------------
  764-  791 (41.33/58.15)	QPPPPPFDSMFGLYQgllhATRVRGVAS
  812-  835 (44.10/23.21)	RPPPPPAAATMAIEK....AAAGQGVDS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     114.87|      35|      51|     670|     704|       3
---------------------------------------------------------------------------
  670-  704 (59.38/36.44)	LSRLALKNKASTDLSSS...DNTQARLQQQWMT..PELSS
  718-  757 (55.50/33.56)	LQRTSLWIRAGPHQQGShhqDLQQHHQQQQQQQrhPQSSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     169.25|      40|     103|      22|      61|       4
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   22-   61 (64.16/35.04)	EVASGAIRHAVEHHLAPVSR.LFTGVLSHVAISHQRLTKVS
   80-  114 (46.34/23.38)	EAASKA..NAQEESL..ILR.SIQTALRLSSQPQQETTAI.
  127-  167 (58.75/31.51)	KVAGGRSAMADALRLASASRpSWTSCCSLETIISGKIGGIS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     119.58|      39|     608|     255|     294|       5
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  255-  294 (57.51/43.19)	RSALCGLVPEIIAALEANLEESTSTSARlSRALHALLVGA
  865-  903 (62.07/42.08)	RRAACEVARAVEKLLALRLRRGIKGRER.ARALLATFLGA
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP21319 with Med5 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) KRLVKAVDAQHPQGAPMPRPPPPPAAATMAIEKAAAGQGVDSERSMAMQGDTQAQNGGEEEEEREAPRRNRRRA
2) WIRAGPHQQGSHHQDLQQHHQQQQQQQRHPQSSSTPQSLLQPPPPPFDSMFGLY
794
724
867
777










Molecular Recognition Features






MoRF SequenceStartStop




NANANA