<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP21318

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMAPLSQGRHGLSSSRKSTHAPGPSSSSSLNGAGSSGFGLGGTSGTGHSRRAQYSLPPPLVPDCLTSLSRISTPADDALLRWRRFSGSSEELEAGQEALCRLSAEEVRAKGRESLLPGYDCQGRGTLDKILDGILWAPEHAAAGPLIALWLFEFGTQEGERKFGLERLTCTWGSTQLSSFYEPLSSENISSPDILRPQQPNLDQAQRLFLLAIEEKAMSRWIYTRAREKKLASESSSRDGDDDISVPTVPNQESHQDASEQGPILNEVLDKHTAHTPAYWKRAGRRDAIRFGRSILLASRRGQGLIRLGLRATLSDGGKLFLETRPLVSQHLKPIFSQASAPSGTRVMLSPLASEARLIDWVGGLIDQDAEGEAAARLKQARSELLSRIGDRGVNVESLSSDWVLCETDSPPVDQKQEGEENASSTRRFLWPADLVFACESNPLQALEPQRPKMQPHGAMEIVSMCTTELAQRTVDMMRGIPIETAKRAKEAGTDPGSVTGRRHSNDTSEGDEEEEEADEGERVKKEEEVEEEKEEEEEEEEEEEEEEEEEEEEVEEEEGEEEGDSTLPRRRVGENGDDGAPVEDGEEDNDVDVGDDTIRSARLEERENEGKAAALAPAQGPAIASGEVLQEGEQAVAESSKSKEDADMDLWGDFVYEGESRQRQPSSSPAKQTNDDDDGGMFGLVTEDDFSFFDDAAAAAAAAASAAFDVETPTASVTGDDEEMRFSEIDNSEQRQDEITSGPMAVDSLPRSNGNSSSSFSTSTIVDHPSVPGFTPSSLSASSPAAHGAHAAKTPRTPYSPTQDMADAHVTIEGEHQGDMYRHSSRISAGGGAPPSAYSAAGGEGEGLEYDDTGSTPFSIQEPGSKEPDSPRKNFDLSSKYEMGKYAISQRPFRRRASRRGPLAGIRSNQLLNMTGISQKRRLNRRGGAEQEDETMVDGEGMTPATASERSSLLAEDSEVDSSRKSELGDEDDEEGIEFDMDGFGQDSDDAASGSDDETDTSIDSAQQAEILAHERHALLKAALTISQAAQARRESQNDTEMAVREHQKKPWPAAATLDVLVSWALDIVTFRDAIVQFFQKYETRPLCLDSRDSFELLTPLESTSACSLGTIFKETRVLEEPSILVGCQGSVTSIKPPAISFWDKLGLTPVSGQKQATAFALQVADASEGWAREVRSYFDRMQQAFRSYGLGSHELADDGLLGIGFPGESTISEALASIHNSTDRWDDSMDSLLSRFKPYLKSGSTILVYVVGEPSSPPPFWAMVLLQTSLQTRVKERLGLPMQRLLVRPLLWRWTSSSGPSLSTTVGQSSSLFGPGRQSFNMSGQARSIYDSLQVTVVPRVNEEPFLPQLPNDKGLPVRFPHLTLAPSAHLTRSRSTSTGRAASEQRFDLRWPTTYVDVVHRSVLLHVGYYIATSEEELTIVTVMDELAQGYDIKAWPGGRGAQKDIDDIWSFACHFARKAKIGWKVVICRGAGGLQFEEVEMWSRLLSKPSSFVGLEHVVDVSLALADDQSNLAIVAPTSMARRTQTEVPTSQEGRLKHSIDTSRVSYVLHPAARIGVTISDGEDVDSQILALRSSLTVTLFQQTNMSTSIAQPSCLFHSALCPHQLWIHLLQVYPNPLSRLEKGTNDDLEHSLDERMRRMANSFHDLEGVARYRHQILEVGQHLPWHLAMLTLLLHGSQLFRR
Length1686
PositionKinase
OrganismAcaromyces ingoldii
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Ustilaginomycotina> Exobasidiomycetes> Exobasidiales> Cryptobasidiaceae> Acaromyces.
Aromaticity0.06
Grand average of hydropathy-0.563
Instability index59.86
Isoelectric point4.79
Molecular weight184598.98
Publications
PubMed=29771364

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP21318
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     102.79|      23|      23|     511|     533|       1
---------------------------------------------------------------------------
  511-  533 (38.88/19.38)	DEEEEEADEGERVKKEEEVEEEK
  536-  554 (32.80/15.21)	EEEEEEEEEEE....EEEEEEEV
  555-  575 (31.11/14.05)	EEEEGE.EEGDSTLPRRRVGEN.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     119.16|      23|      23|     894|     916|       2
---------------------------------------------------------------------------
  894-  916 (39.72/20.24)	RRRASRRGPLA......GIRSNQLLNMTG
  920-  941 (33.63/15.99)	KRRLNRRGG.A......EQEDETMVDGEG
  942-  958 (22.70/ 8.36)	MTPAT.....A......SERSS.LLAEDS
  959-  983 (23.11/ 8.64)	EVDSSRKSELGdeddeeGIE....FDMDG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     332.36|      86|      91|     581|     668|       3
---------------------------------------------------------------------------
  593-  680 (130.27/75.41)	VGDDTIrsARLEERENEGKAAALA..PAQGP.AIASGEVLQEGEQAVAESSKSKEDADMDLWGDF...VYEGESRQRQPSSSP....AKQTNDDDDGG
  685-  763 (95.21/49.17)	VTEDDF..SFFDDAAAAAAAAASAafDVETPtASVTGD...DEEMRFSEIDNSEQRQDEITSGPM...AVDSLPRSNGNSSSS....FSTS.......
  764-  849 (106.88/56.23)	....TI....VDHPSVPGFTPSSL..SASSP.A.AHGAHAAKTPRTPYSPTQDMADAHVTIEGEHqgdMYRHSSRISAGGGAPpsaySAAGGEGEGLE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.51|      12|      91|    1530|    1544|       4
---------------------------------------------------------------------------
  495-  506 (24.20/ 8.69)	PGSVTGR.RHSND
 1532- 1544 (19.31/ 9.53)	PTSQEGRlKHSID
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     118.70|      34|     137|     182|     221|       7
---------------------------------------------------------------------------
  182-  205 (34.43/16.27)	.................PLSSENIS...SP.DILRPQQPNLDQAQ
  212-  255 (45.31/27.39)	IEEKAMSRWIytrarekKLASESSSrdgDD.DISVPTVPNQESHQ
  418-  456 (38.95/15.25)	GEENASSTRRflwpadlVFACE..S...NPlQALEPQRPKMQPH.
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP21318 with Med13 domain of Kingdom Fungi
Unable to open file!