<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP21296
Description |
Mediator of RNA polymerase II transcription subunit 5 |
Sequence | MAIEQTKTDWQPTIDINKNVSSSFVEPELAVLMHFLMDEPVDFRQKVEATKMLIGARIQSGLQDQEAYTITFFELLLGAAGGLAAVLSTPKALGGSESYSSIWQSGLCSLVPSIIQTIQAERTDVVRSDSELDDIEKACHLFVEKAKSLMDKCEVHRKATNSDKQNDVEKDADPDTIMMDSLISSTGGEGSSERSSIQAMLVQSLVDRDAVRLDRWQTGKHSLAEAEMLLRPSQITMDAKHMSMTVSEYTSQRLLSGEALDDPNFVEAIESDYSTQDQLCRALMESMLNWANNNELEPLSRACSMLLESSSALQIWLFFVSPAQALQPICVILDNPDLLQSGEDPSVLAPIVLFGQFVIQIGLGSGASLEDLCPSSRSRFLPSVMRSLTATRPLDRLSKMEQETVANWITALFGSDGISDDLIRASSPQLLMRIAPTIFSQAIIATSTNVIDMDTLRGGLTYFLQDLLSYTLPGALRSVANQIQRGQSGENADAENSKKYREVCIEVLRCVLLDESCSVTIKRLVSQQIVAVLEKDQLKAPLSDAEQGLLQHFIPFNQSQTRRTDIWIKGASSTMLPSTLDPLLNMNASLYSIMTQRGLDAVVSLLRKSEKSVIIQKPICFSLALIALQDTNQPKSSLADENTIRIITQLLQQDRSIDLRLLLTLCQAHLPHIHNAISAFLQLENATKKRMLSV |
Length | 694 |
Position | Tail |
Organism | Meira miltonrushii |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Basidiomycota> Ustilaginomycotina>
Exobasidiomycetes> Exobasidiales> Brachybasidiaceae> Meira.
|
Aromaticity | 0.05 |
Grand average of hydropathy | -0.065 |
Instability index | 49.12 |
Isoelectric point | 4.88 |
Molecular weight | 76634.88 |
Publications | PubMed=29771364
|
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364142
|
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP21296
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
3| 139.12| 36| 93| 87| 124| 1
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87- 122 (65.80/42.81) LSTPKALGGSES.YSSI..................WQSGLC.SLV.......PSIIQTIQAER
183- 241 (41.98/22.99) ISSTGGEGSSE..RSSIqamlvqslvdrdavrldrWQTGKH.SLAeaemllrPSQI.TMDAKH
260- 289 (31.34/14.14) LDDPNFVEAIESdYST....................QDQLCrALM.......ESMLN......
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
3| 211.71| 75| 179| 362| 449| 2
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345- 387 (39.06/37.01) ..................................PSVLAPI..VLFGQFVI........qiG.LGSGAS..LEDLCpssrSRFLPSVMRS
394- 478 (103.38/74.28) LDRLSKMEQETVAnwITALFGSDGISdDLIRASSPQLLMRIAPTIFSQAIIA.TSTNvidmDtLRGGLTyfLQDLL....SYTLPGALRS
580- 632 (69.26/39.26) LDPLLNMNASLYS..IMTQRGLDAVV.SLLRKSEKSVIIQ.KPICFSLALIAlQDTN.................................
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