<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP21295

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMSQRFGASVATPAASRLAESSQNNNAFTLPPSITTDAHISLVQLPIPSDSVIHWQRHTTSSSNLQQTDHAHHRADPSIVQNSVHDLMQIAQEQAQRNASSRTELKSALLNDIFWTCEERQQKGSYVSSGNNADNDSVSQGPASIWTFQVEHVNAAESSNAIHKGRNTTGGSLDRMKKVHEKLTQSGAAQTEGTLSLQNLYKKGAQDEQSLVPNNEDDHQPLSQFIKALEEFLLLRWVWTRQSERHATSKRQMQPQKLNPKTESTIDGKVKASTDEEEEGALGDDGSEEVKEGQRGQESSNLWSGNQLARDKPVVRLGKGVMVYDRPNKTQRGLLSFDSESTNMPLQMSLRCFADDTGHIFLETWPCDNSASQLVKENDANPGDTLLLAPLMIKARFISFVGPVAQISDNVTVRSSREALFDLLQLNAVDTSFLVDEWISCSYQGRVFLWPAQLCLLHKLSSPLPYAKMPSLVESTLHDVTAKARRCVRETLGLSVTPDRELTASSQEEEDDAMEEEDDDEQDEQGMDTRNSGSPAKIGQTLDTADAKGASDRSALDASKAAATSMDIKPNDTVDSLSLPAYQSGTRRNSAVAMDSNSKDEEMDLWGSFGFVGQEDSQLPPMPRSRDGFDDTGFGLVTEDDFSFFDDGAADFSAFTNDALDVGEMNIHQPDGDATITEMPMEEDTEVLPEAIHVEDEQGTQQIDQDHEESTGTGSSAIDPPSLPGFTPGSFSESSPAVGGMSVKTPRTPFSPNQELADTAITIEGEHGSLENGMYGHHQYNHHHVMPNDHSNEEYESMNNYDSSMGPPEVRFMPNQKRRQNWANKGQRDITSKYEQGKFAMPFVPLRKKQGDEESSDQQHQPQRQTGRSDQESALLAPTRSRLGHRTTVNGRRVSFSRTGAHPHSGLIGALKGRLGVLRGDEEMSEATGDGTMSERSSLMEEDSADDESVSSDQTSEEDEALTEQRTEMLQSSIHFLRFANYSNAPSFDDHTQDELVELQPSTNVEPAEWNDLVHHLIENPQLRLQIGQSLGQIEYAGSVSRYDSQHLFTLLQGHESDCTLGTCMGGEKSNQNANKSSLLQVMEPSNVLVGCQGSVTNVAPSALHYWDKLGLTAVGGQKDVAAFALHTNDVNIAMQGEIRNWLDSMGKVFRENGLGSHTMSEHGLLDIGTVSRSKTLADTLNLMAKDAEQWSDTVDSLVSRVVGALKKHNFVVMYAIGSFHVPGQIQSFVRLQRDLRSSASLRYGIPGDSIVVRPCSWESVRLTSSISRDASTNSLRRMAMSIYDSLQVTVDVQYNREQYLPKFSAVPTAVQYPSFSILPASFGNNVGSAFKLDWYFKSVDIFERGTLLHVAYHLAPSAGQPSMLAIIDERGQGYTATAWRRTGSMQDEIQRIWNITTEFTMRSRNMWKIVLCKDRAIGMAEVRMWSKILKDRTALENANALEVILSCSELDRVLSLVLPLQDLNELECRRQAAVETIPNSKSGGKYIDASIWKYALYPQRRMALRNSVLGKDDGKDDMFSLPILPLRSSLTMTIPQSWNSTTTLSSNENGVNSKAWSRSAPHHLWIHILQVFKLDPNEESMQATQNVESSTSSSTPTPASIAHSDAQSTGSGVEQKNTPSDPFGIESRLERITKSFQELELIARERAMLPMDDPTTIHLPWHLAILQNLLNLSSAVFIGN
Length1680
PositionKinase
OrganismMeira miltonrushii
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Ustilaginomycotina> Exobasidiomycetes> Exobasidiales> Brachybasidiaceae> Meira.
Aromaticity0.06
Grand average of hydropathy-0.574
Instability index53.84
Isoelectric point5.02
Molecular weight185736.86
Publications
PubMed=29771364

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
ECO:0000256	RuleBase:RU364134
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP21295
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     293.44|      72|     173|     497|     568|       1
---------------------------------------------------------------------------
  497-  568 (112.26/56.62)	PDRE..LTASSQEEEDDAMEE..ED.DDEQDEQG....MDTRNSGSPAKIGQTLDTADAKG.....ASDRSALDASKAAATSMDIK
  579-  654 (81.57/39.05)	PAYQ....SGTRRNSAVAMDS..NSkDEEMDLWGsfgfVGQEDSQLP.PMPRSRDGFDDTGfglvtEDDFSFFDDGAADFSAF...
  669-  743 (99.62/49.39)	PDGDatITEMPMEEDTEVLPEaiHV.EDEQGTQQ....IDQDHEESTGTGSSAIDPPSLPG.....FTPGS.FSESSPAVGGMSVK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     540.18|     172|     644|     177|     424|       2
---------------------------------------------------------------------------
  177-  367 (260.55/204.52)	KVHEKLTqSGAAQTEGTLSLQNLYKKGAqDEQSlvpnNEDDHQPLSQFIKALEEFLLLRWVWTRQSERHATSKRQMQPQKLNPKTESTIDGKVKAST.....DEEEEGALGdDG..SEEVKEGQRGQESSNLWSGNQLARDKPVVRLGKGVMVydrpnKTQRGLLSFDSEStNMPlqmslrCFADDTGHIFLETWPCD
  824- 1002 (279.63/124.42)	KGQRDIT.SKYEQGKFAMPFVPLRKKQG.DEES....SDQQHQPQRQTGRSDQESALLAPTRSRLGHRTTVNGRRVSFSRTGAHPHSGLIGALKGRLgvlrgDEEMSEATG.DGtmSERSSLMEEDSADDESVSSDQTSEEDEALTEQRTEML.....QSSIHFLRFANYS.NAP......SFDDHTQDELVELQPST
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      63.77|      20|     620|     397|     424|       3
---------------------------------------------------------------------------
  397-  424 (27.58/32.69)	ISFVGPVAqisdnvtvRSSREALFDLLQ
 1033- 1052 (36.18/22.41)	IEYAGSVS........RYDSQHLFTLLQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     175.66|      54|     890|     426|     485|       5
---------------------------------------------------------------------------
  426-  485 (81.70/71.76)	NAVDTSFLVDeWISCSYQgrVFlwpAQLCLLHKLSSPLPYAKMPSL...VESTLHDVTAKARR
 1324- 1380 (93.95/60.32)	NNVGSAFKLD.WYFKSVD..IF...ERGTLLHVAYHLAPSAGQPSMlaiIDERGQGYTATAWR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.60|      12|     279|    1254|    1265|       6
---------------------------------------------------------------------------
 1254- 1265 (24.17/11.08)	PCSWESVRLTSS
 1535- 1546 (23.43/10.54)	PQSWNSTTTLSS
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP21295 with Med13 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) AESSNAIHKGRNTTGGSLDRMKKVHEKLTQSGAAQTEGTLSLQNLYKKGAQDEQSLVPNNEDDHQPLS
2) EMDLWGSFGFVGQEDSQLPPMPRSRDGFDDTG
3) ERHATSKRQMQPQKLNPKTESTIDGKVKASTDEEEEGALGDDGSEEVKEGQRGQESSNLWSG
4) ESMQATQNVESSTSSSTPTPASIAHSDAQSTGSGVEQKNTPSDPFGIES
5) FTNDALDVGEMNIHQPDGDATITEMPMEEDTEVLPEAIHVEDEQGTQQIDQDHEESTGTGSSAIDPPSLPGFTPGSFSESSPAVGGMSVKTPRTPFSPNQELADTAITIEGEHGSLENGMYGHHQYNHHHVMPNDHSNEEYESMNNYDSSMGPPEVRFMPNQKRRQNWANKGQRDITSKYEQGKFAMPFVPLRKKQGDEESSDQQHQPQRQTGRSDQESALLAPTRSRLGHRTTVNGRRVSFSRTGAHPHSGLIGALKGRLGVLRGDEEMSEATGDGTMSERSSLMEEDSADDESVSSDQTSEEDEALTEQRT
6) IHWQRHTTSSSNLQQTDHAHHRADPSIVQNSVHDLMQIAQEQAQRNASSRT
7) MSQRFGASVATPAASRLAESSQNNNAFTLPPS
8) TPDRELTASSQEEEDDAMEEEDDDEQDEQGMDTRNSGSPAKIGQTLDTADAKGASDRSALDASKAAATSMDIKPNDTVDSLSLPAYQSGTRRNSAVAMDSNSKD
155
601
243
1579
654
52
1
496
222
632
304
1627
966
102
32
599










Molecular Recognition Features






MoRF SequenceStartStop




1) EDDFSFF
2) FVPLR
3) QGKFAM
638
842
835
644
846
840