<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP21291

Description Mediator of RNA polymerase II transcription subunit 17
SequenceMSDDVLHLSIEPPLTITASARKSLEKARREALQSSSAKDAGSEEDGLKDSINSLQSTVEKITKLDTLRRAWIDENRSVKPPELPLSIRLQKLWSERGDFSRFRASTLLNDDSIVAKDGNADDAAVEEDLGAILSDLEDAAADADGQKKDGELDKEGTLNTKNGDVMSIQDMIQVRKDMLDKLGLAHNSLYFSHALVSLLINSTKPGNEAPSMAGSGGPGSITRAGSAAASNRLGADLLGGAASSRSVTGGTQAMGSSTALETELGIEPYVFGASRLEALRRDVEHSREDEDEDENMDEDDDDEGAEKERLRVERQIAKLLDEEVEEHAKDLIERVEGKKEGIRSAIDILRKGAKTIHPENEGAGREKVRWQALMLARRSGWSLTPDKPVRGTAAKKRELLQDFGPIKRDEPARDAWIGYGVPESSIRYARQALAYLSHSSTEGDRPADALLFASRPQKKVKLEVIIGEEVWTSDGPANGEDQRSSLDQVLRQAQSEFVDEELFDSIVAESRILSIAGLSNVSIDNEDQVTFDLNAFTKLRFVRQDTSKEVTDETGEGQHASPIMTSMLAILRLGLIRRYRQKAGIESKQKEATTESENVKAPLLQSLLGLIHYASFSAHLHVKLTLLTKLYPNVQLDLNMFERIGDVRSWLMIFLQQSDKIGNLEAIKQLGGSGTIFIDGKPFAYLSFGYPSQISLTLPLRKLSDGSGTGVNLPSVDLTSLEGILTKELVRLQGSKESL
Length739
PositionHead
OrganismMeira miltonrushii
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Ustilaginomycotina> Exobasidiomycetes> Exobasidiales> Brachybasidiaceae> Meira.
Aromaticity0.05
Grand average of hydropathy-0.474
Instability index47.72
Isoelectric point5.03
Molecular weight80986.88
Publications
PubMed=29771364

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP21291
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     240.54|      78|      87|      37|     120|       1
---------------------------------------------------------------------------
   37-  120 (119.78/77.58)	AKDAGSEEDGLKDSINSLQSTVEKITKldTLRRAWIDENR.SVKPPELPLSIRlqKLWS......ERGDFSRFRasTLLNDDSIVAKDGNA
  328-  412 (120.76/63.91)	AKDLIERVEGKKEGIRSAIDILRKGAK..TIHPENEGAGReKVRWQALMLARR..SGWSltpdkpVRGTAAKKR..ELLQDFGPIKRDEPA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      90.62|      28|     152|     129|     156|       2
---------------------------------------------------------------------------
  129-  156 (46.04/24.33)	LGAILSDLEDAAADAD.GQKKDGELDKEG
  276-  304 (44.57/23.33)	LEALRRDVEHSREDEDeDENMDEDDDDEG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      94.55|      30|     152|     548|     577|       3
---------------------------------------------------------------------------
  548-  577 (50.54/29.30)	KEVTDETGEGQHASPI.MTSMLAILRLGLIR
  701-  731 (44.01/24.67)	RKLSDGSGTGVNLPSVdLTSLEGILTKELVR
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP21291 with Med17 domain of Kingdom Fungi
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