<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP21289
Description |
Mediator of RNA polymerase II transcription subunit 11 |
Sequence | MSTEPSTADHLNEMIGKVRAEKAKVDMQRRHTEIYSRNEKAQRLVKRLQDCDSNIVSLLSQAADCLQSLISTAADQSSSSGRGRIREVDDHEERLATFEARAQEWYATLHDVQIGLRSAARNLRKVQQPPLSMQASMQQSSSSSGSSSSQTRLGSATKGHSLGIALSEGNTPVNMSRAGSHESLQTVVGDGRELDDRGQQSNREVLSSDRQPSKHLGSVGDERKQGSRKDQRSLLGHFVDGDSGSGIVQMQEGEFEDEIKLSLSALRQQERGWKDLADALKAVASERKSDRSSMTKEVQTKSPSTTTKEQEMRQIEADMTESFATSDKRLMGALMHLYMEVLPETSIAPVTARKLG |
Length | 356 |
Position | Head |
Organism | Meira miltonrushii |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Basidiomycota> Ustilaginomycotina>
Exobasidiomycetes> Exobasidiales> Brachybasidiaceae> Meira.
|
Aromaticity | 0.03 |
Grand average of hydropathy | -0.794 |
Instability index | 58.84 |
Isoelectric point | 6.53 |
Molecular weight | 39204.14 |
Publications | PubMed=29771364
|
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364147
|
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
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Interaction
Repeat regions
Repeats |
>MDP21289
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
3| 252.07| 60| 60| 193| 252| 1
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127- 177 (71.67/39.95) ......QQPPLSMQASMQQSSSSSGSSSSQTR..LGSATKGHSL.G..IALSEGNTPVNMSR
193- 252 (101.27/59.69) ELDDRGQQSNREVLSSDRQPSKHLGSVGDERK..QGSRKDQRSLLGHFVDGDSGSGIVQMQE
254- 311 (79.13/44.93) EFEDEIKLS....LSALRQQERGWKDLADALKavASERKSDRSSMTKEVQTKSPSTTTKEQE
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 120.39| 40| 62| 6| 50| 2
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7- 50 (58.36/39.77) TADHLNEMI..........GKVRAEKAKvDMQRRHTEIYSRnekAQRLVKRLQD
62- 111 (62.03/28.76) AADCLQSLIstaadqssssGRGRIREVD.DHEERLATFEAR...AQEWYATLHD
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