<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP21288

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMSGREKAKEATTFNGPFKFPMTNVNNASNKSINGVNGTHDTGNTNDHSTNTIKYDILFQPKYTRAWEKSRKIESNNDTIPTREELDAQLRPEDEGLVPLNAIAGRIVHYAWQLFANQVEINPSISPLERRKRIYDDAHEARKQLIKLLVLTQWSKASPELQVARNLIAFINDHIAQSEAALDALQATRGVLNNARLRNYDLKTAIEVLSTGSPQSVPPSVKPFLNADKPFSNEEAIALVKELDDVLRLRLACEEFLATPLLSYTISDGRACFVAYGLFETDLTLSGSSQDDRWFCLRVKFDFHISGAGSDKFPRQLKGQQRLDLLDLANNELAPRSIAAVTEAQEQITEGDETVQNAEGHAALSSSKDTRIEERKDTPLIRLYNLLQSQSLHYRLDILHWQATQLIKLSWGQRLTVFIDSMRTLHIQYWKNARSSTDNAKEDWDPIARAEICVSVIETDPRQGASAVIKSLFERSDDRMQKPISLQLSVEWNVKGVIIDYLGSREITVDHRNLDAEAILIDVTQMHAKAAVEAFKTRIEASALRRTMRTEKRLKSVGPIEEYGLLIHVNERLTVELTIDRMSGQVQLAEVSGMSEGLRDETLSCSDLARMARTDYVREACKAINERPRSIIGILQRLRCQILIEDLEEKCNLNGLECSTRMPLRQIDYAQLQATPNTLLFIAMQQCPTYYLVVQVAEDCFRVALMCVGTFLEEMITSMRIVSLERLDWMYVLKTCQQSRERLGKRKRDDDVSNTIDMLSMSEDDLAILHSYSVALVSYHKIEEQLRLRGVPYVHVGGMTKQKEKSFWSQDDQAESPDSEDSVSTIVPSLCIDARMLLGNLQGSYVKRNILLRLRNWNDPVRSRVELALKVTLRSGIVSRTDIVEGRNKIHYDTKAGILVFSISEIETYFEQFLTTWRRIEKVLNLLKTLWILGQYEKSGREHQFDFRLHSFDLVHATFTYDQGLMAKIGWIHDPAKRRNGSFALAFDTIKSDDASAEETRRTNPHAILRFALEQALNRGNEAKPNFWLSFLMLLRRTLPLARLVCGYPNECLESIETPELGVRSASWIQLTFLDRFKLDVRLLTANRVLFVDAGRATSHRRGKEEKKSNVEDEFTLHSSSRDVDMDDLDEAILEWSAIPSFDKIIQELAGEILQKGAKKDAMQIQESTQGRSNSVLTFADALLYRGNSDEVEWILKELISKVQKVIFTDTNSIDG
Length1215
PositionTail
OrganismMeira miltonrushii
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Ustilaginomycotina> Exobasidiomycetes> Exobasidiales> Brachybasidiaceae> Meira.
Aromaticity0.07
Grand average of hydropathy-0.363
Instability index49.09
Isoelectric point5.95
Molecular weight138261.71
Publications
PubMed=29771364

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU365082
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP21288
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     367.74|     122|     164|      60|     189|       1
---------------------------------------------------------------------------
   60-  189 (195.87/161.93)	PKYTRAWEKSRKIESNNDTIPTREELDAQLRPE...DEGL.VPL..NAIA.GRIVHYAWQLFANQVEINPSiSPLERR..KRIYDDAHEARKQLIKllvLTQWSKASPELqvarNLIAFINDHIA.QSEAAL.DAL.QATRG
  217-  350 (171.87/122.25)	PPSVKPFLNADKPFSNEEAIALVKELDDVLRLRlacEEFLaTPLlsYTISdGRACFVAYGLFETDLTLSGS.SQDDRWfcLRVKFDFHISGAGSDK...FPRQLKGQQRL....DLLDLANNELApRSIAAVtEAQeQITEG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     375.69|     122|     166|     899|    1028|       2
---------------------------------------------------------------------------
  899- 1028 (190.53/165.77)	VFSISEIE.TYFEQF.....LTTWRRIEKVLNLLKTLWILGQYE.KSGREHQFDFRLHSFDLVHATFtyDQGLMAkigWIHDPAKRRNGSfALAFDTI....KSDDASAEETRRTNPHAILRFAlEQALNRGNEAKPNfWL
 1062- 1194 (185.16/131.94)	VRSASWIQlTFLDRFkldvrLLTANRVLFVDAGRATSHRRGKEEkKSNVEDEFTLHSSSRDVDMDDL..DEAILE...WSAIPSFDKIIQ.ELAGEILqkgaKKDAMQIQESTQGRSNSVLTFA.DALLYRGNSDEVE.WI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     485.35|     153|     166|     431|     595|       3
---------------------------------------------------------------------------
  351-  426 (50.70/29.64)	..............................................................................................DETV.....QNAEghAALSSSKdTRIE.ERKDTPLIRLYNLLQSQS..LHYRLdI...LHWQATQLIKLSWgQRLT..VFIDSMRTLHI
  431-  595 (219.85/222.00)	NARSSTDNAKEDWDPIARaEICVSVIETdPRQgasavIKSLFERSddRMQKPISlQLSVEWNVKGV.IIDYLGSREItvDHRNLDAEA...ILIDVTQ.....MHAK..AAVEAFK.TRIE.ASALRRTMRTEKRLKSVGPIEEYGL.L...IHVNERLTVELTI.DRMSGQVQLAEVSGMSE
  600-  762 (214.80/175.09)	ETLSCSDLARMARTDYVR.EACKAINER.PRS.....IIGILQRL..RCQILIE.DLEEKCNLNGLeCSTRMPLRQI..DYAQLQATPntlLFIAMQQcptyyLVVQ..VAEDCFR.VALMcVGTFLEEMITSMRIVSLERLDWMYV.LktcQQSRERLGKRKRD.DDVSNTIDML...SMSE
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP21288 with Med14 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) MSGREKAKEATTFNGPFKFPMTNVNNASNKSINGVNGTHDTGNTNDHSTN
1
50










Molecular Recognition Features






MoRF SequenceStartStop




1) IKYDILFQPKY
52
62