<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP21279

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMPATPRRVEEQSGASHTSDLLSASSIPGTSNHYKAQPVAYPGDSAVKAESSRAGRGNGVEGLSNGNGGSGSSNGEANGIAGPNVQSSEPADRKPMTSSSASANGSLMPLNASSPSKSNGHLSPPASDPTFMRPPLSLKAQGKVKAVEAPAVVTKTSRSTSPPIPGSGVKLSHSQMFRASSPPRTGHDKRGGILLDGLKSELNQEDGGLIPLAAVIDRVASDAYETLQNLGETMTSLPSGARRVRIFNTALDLRRQLIKLYVLTKWAKGAKHLQHITNVLGLTHEQSFQTVDARDHIKETRSLLPNARGRNHDIVTAIDVLSAGEPQRLPKSIATEAIPPEPLSDSEARTIVKELDTTLHKRLTGYEILPLALQPALEASFKISNGRVELAAPNLFSMSLTLSGEQQDDRWYLLSIRFDYDVTGEGKERFPNDLWESQREAFIAQANAVLEPRNNLEQEAIADTPPDLQARAQEAPIIRLYNFLRSQALEYQLDILAYQFSELARLKWRGSITWQWEQRVLIVKYWTPTLPVAGGKSDHANKWNPLRGGIIRLRVQDEALHSASDGVLASLSMREDSAIDEVDGKDAELHSDDREKQLRLTLSWELDKKLATQTNFRSDVRAEVNAQALDANALLDDVTAKHAALSIKAIKERLSNSKALNKTMMSSPGAIVEESDASGAALVVRLHETISIRIRLEAKSGQISLTQLNSSRKHVGSSSTTQSVGSLLASFSGSPSIARLKDATRLLNVAPEAIVEVLLRLRTAAVCDDLEAKAGRVGLGCLRRLNLGQEEYGKFGISQPSSLLFLPLPQCPTFYLVSVVREEGVRVALTSAMPVMYGDGTFGSSLSVQSLQWLDASRLTDRATSSTQNFLGKRRRGQHTSGSLSGLGTHSTSAASVTNLDSSDLARLHSYATALTLSLQIESQLQMRSIPFAYIPPNRQRSSPESLELTKSDDEYQRGQALVPAITLRAADLFGSSASPLLRRSVVLKIRDYWNPKRSSLGLVTKLKFNASLGTNQISGSESAAQSGLQGAPPTAVLNTRTSTISFQAQNLSQAIDIFRFEWNRIARIVSLAAYLSKAPSLASLKTFTLSQVKFTYTGQDGQELMGEVTWESEQAVPGHCLAFSSSPITAQGNPHALISRHLERLLNASSTPPDWSAFFTLLRQTLPILTLVQGYLVEDEAAMEDEGKPDMELINATRYQVILVEKYTLDVRLAKDGRACISDGVESSSSEAPRAGEAESGTGIGPREGSWTHPIPQLAQIMGRFAEEGALVFGSTMLLPADKTSLLSALIEQVNEAVLVEEGLK
Length1305
PositionTail
OrganismPseudomicrostroma glucosiphilum
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Ustilaginomycotina> Exobasidiomycetes> Microstromatales> Microstromatales incertae sedis> Pseudomicrostroma.
Aromaticity0.05
Grand average of hydropathy-0.296
Instability index44.60
Isoelectric point6.82
Molecular weight141209.68
Publications
PubMed=29771364

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP21279
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      75.64|      24|      25|      85|     109|       1
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   84-  108 (37.47/21.07)	VQSSEPADRKPMTSSSASaNGSLM..P
  109-  134 (38.17/17.53)	LNASSPSKSNGHLSPPAS.DPTFMrpP
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      81.40|      25|      25|       1|      25|       2
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    1-   25 (41.98/25.41)	MPATPRRVEEQSGASHTSDLLSA.SS
   26-   51 (39.42/23.37)	IPGTSNHYKAQPVAYPGDSAVKAeSS
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     306.01|      80|     123|     294|     373|       4
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  294-  373 (129.86/67.70)	DHIKETRSLLPN...ARGRNHDIVTAIDVLSAGEPQRLPKSIATEAI...PPEPLSDSEAR.TIVKELDTTLHKRLTGYEILPLALQ
  420-  498 (110.00/56.28)	DVTGEGKERFPNdlwESQREAFIAQANAVL...EPR...NNLEQEAIadtPPDLQARAQEA.PIIR.LYNFLRSQALEYQLDILAYQ
  906-  961 (66.15/31.08)	..................RLHSYATALTLSLQIESQLQMRSIPFAYI...PPNRQRSSPESlELTKSDDEYQRGQAL..........
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     302.32|     122|     449|     667|     840|       5
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  685-  840 (161.53/167.29)	LHETISIRIR.....LEAKSGQISLTQLNSSrkhVGSSSTTQSVGSLLASFSGSPSIARLKDAT..............................................................................................................................................................rllnvapeaivevllrlrtAAVCDDLEAKAGRVGlgclrrlNLGQEEYGKfGISQPSSLLFLPLPQCPtfYLVSVVREEGVRVaLTSAMpVMYGDGT
  981- 1041 (50.92/ 8.39)	LRRSVVLKIRdywnpKRSSLGLVTKLKFNAS...LGTNQISGSESAAQSGLQGAPPTAVLNTRT...............................................................................................................................................................................................................................................................
 1219- 1284 (89.87/35.88)	................................................................stisfqaqnlsqaidifrfewnriarivslaaylskapslaslktftlsqvkftytgqdgqelmgevtweseqavpghclafssspitaqgnphalisrhlerllnasstppdwsafftllrqtlpiltlvqgylvedeaamedegkpdmelinatryqvilvekytldvrlakdgrACISDGVESSSSEAP.......RAGEAESGT.GIGPREGSWTHPIPQLA..QIMGRFAEEGALV.FGSTM.LLPADKT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      67.29|      20|      26|     233|     252|       6
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  233-  252 (33.08/20.04)	MTSLPSGARRVRIFNTALDL
  262-  281 (34.22/20.98)	LTKWAKGAKHLQHITNVLGL
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     100.05|      29|     602|     509|     539|       7
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  509-  539 (51.35/40.29)	GSITWQWEQRVL..IVKYWTPtlPVAGGKSDHA
 1106- 1136 (48.70/31.66)	GEVTWESEQAVPghCLAFSSS..PITAQGNPHA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      87.54|      28|     603|     582|     610|       8
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  582-  610 (44.39/35.15)	DGK.DAELHSDDReKQLRLTLSWELDKKLA
 1186- 1214 (43.15/29.01)	EGKpDMELINATR.YQVILVEKYTLDVRLA
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---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.02|      14|      23|     157|     170|      10
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  157-  170 (27.03/15.77)	RSTSPPIPG....SGVKL
  177-  194 (20.99/10.28)	RASSPPRTGhdkrGGILL
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP21279 with Med14 domain of Kingdom Fungi
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