<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP21260

Description Mediator of RNA polymerase II transcription subunit 12 isoform X1
SequenceMDTNGPVVEVDRRKRHYRILKLLPGLLFRDALEEAGIAEEPQLSEAMNLYSTERRLILRGLLSDQNKNANMIVSALKQKHFPIPGKDGPLPVSVDQWKAVQSSSNILSVKGGKSDADLEEIKEAISVLLQLPNSSSPSTETGLDESQGSVKRPFGSIYNKMDLGEGTPGCEECKRAKRQKVSDERSSYIQGNSPIPSDDEDTWWMRKRLKSLEPMKVDPPVKSTKQVSRNRQKIVRKTQSLAQLAAARIEGSQGASTSHVCNNKVSCPHHRTGLEGETPKSTDPTKVSHGGDIVSIGKALKQLRFMEKRTITVWLMTVIRQLVEETEKTIAKVGQFGRTFTSVDDRSSIRWKLGEDELSAALYLMDVSNDLVLAVKFLLWLLPKVSSPSSTFHSGRNILLLPKNVESQVCEVGEAFLISSLRRYENVVIATDLIPEVLSAIMHRASAVVASNGRLSGSPALAYSRYLSKRYSNVASVIEWEKNFKATCDKRLLSELESGQSVDGELGFPLGVPAGVEDLDDFFRQKISGVRLSRAGLNMREIVQRNVNVEDAFHYFYGKERKLFAAGAHKGPPVEKWDDGYQIAQKVITELMDCIRQTGGAAQEGDPSLVSSAVSAIVGNVGQIIAKLSDFRAGGSYSSFPAATDSLNCARRILRIHISCLCLLKEALGERQTRVFEVALATEACSALAGVFSPGKASRNQYQSSPESHDSNTNASNDILNSSTKIGLGRTTKVAAAVSALIIGAVAQGVTSLERLVTVFKLKERLDIIQFVRSSRSNSNGNARSSGAFKGDISLEVYVHWFRLLVGNCRTVSDGLVVELLGEPTVIALSRMQRMLPLGLVFPPAYSIFAFVVWRPFLLNTSIAAREDFNQLYQSLTTAIGDAVKHLPFRDVCLRDSQGFYDLVAADGSDAEFAAILELNGSDMLLKSKAFVPLRARLFLNAIMDCKMPQSLFMQSEGNQVSGHGESKVQYAERETKLVDKLVHILDTLQPAKFHWQWVELRLLLNEQALIEKLETQDMSLVDAIRSSSPSPEKAAASENEKYFIEIILTRLLVRPDAAPLFSDVVHLFGRSLADSMLLQVKWFLGGSDVLFGRKTIRQRLLNIAETKGLSTKTQFWKPWGWCSYGFDPLTNRGDKKKFEVTSLEEGEMVEEGIDSKKYVKGLTPTSDIESYNVTQQRVTERALIELLLPCIDQSSDDSRNTFANDLIKQLSNIEIQISAVTRGTNKQAGPAPSGVEGPTSKGNNRKGIRGGSPGLARRAAVAADSAPPSPAALRASMSLRLQLLLRLLPIICADREPSGRNMRHGLASVVIRLLGNRVVNEDAELCVNLMQSSFSKREAESSTEAASAAFADLSSESLFDQLLLVLHGLLSSCQPSWLRPTKSTNESGKDFAAFDREMADHLQNDLDRMQLPERIRWRIQTAMPVVVPSIRCFVSCQPPPVPNTALAVLQTSISTPGFYSGISNPPQRNQVPLARTVANIPGKSKSLPSQDYDMDVDPWTLLEDGAGSGPSSGNSALIGSADHGNLRASSWLKGAVRVRRKDLTYIGAVDDDS
Length1554
PositionKinase
OrganismPrunus yedoensis var. nudiflora
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> rosids> fabids> Rosales> Rosaceae> Amygdaloideae> Amygdaleae> Prunus.
Aromaticity0.06
Grand average of hydropathy-0.239
Instability index49.11
Isoelectric point8.59
Molecular weight170619.63
Publications









Function






Annotated function


GO - Cellular Component
GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP21260
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     596.41|     205|     890|     280|     527|       1
---------------------------------------------------------------------------
  280-  527 (278.42/271.16)	KSTDPTKVSHGGDIVsigkalKQLrfmekRTITVWLMTVIRQLVEETEKtiAKVGQFGRTfTSVDDRSSIRWklGEDELS..AAlylmdVSND............LVLAVKFLLWLLPKVSSPSSTfhSGRNIlllpknvesqvcEVGEAFLIssLRRYENVVIATDliPEVLSAIMHRA.SAVVASNGRLSGSPALAysrYLSKRySNVASVIEWEKNFKATCDKRLL....SELESGQ...SVDGELGFPLGVPAGVEDLDDFFRQKI
 1194- 1420 (317.99/201.23)	QSSDDSRNTFANDLI......KQL.....SNIEIQISAVTRGTNKQAGP..APSGVEGPT.SKGNNRKGIRG..GSPGLArrAA.....VAADsappspaalrasMSLRLQLLLRLLPIICADREP..SGRNM............RHGLASVV..IRLLGNRVVNED..AELCVNLMQSSfSKREAESSTEAASAAFA...DLSSE.SLFDQLLLVLHGLLSSCQPSWLrptkSTNESGKdfaAFDREMADHLQNDLDRMQLPERIRWRI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      67.70|      22|      31|     883|     905|       4
---------------------------------------------------------------------------
  883-  905 (34.73/27.88)	AVKHLPFRDVCLRdSQGFYDLVA
  915-  936 (32.97/20.96)	AILELNGSDMLLK.SKAFVPLRA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.31|      17|      22|    1063|    1081|       7
---------------------------------------------------------------------------
 1063- 1081 (25.05/26.24)	SDVvhLFGRSLADSMLLQV
 1088- 1104 (30.26/22.54)	SDV..LFGRKTIRQRLLNI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     139.21|      45|      70|     609|     653|       8
---------------------------------------------------------------------------
  609-  653 (74.07/46.42)	LVSSAVSAIVGNVGQIIAKLSDFRAGG.SY.SSFPAATDSLNCARRI
  680-  726 (65.14/39.87)	LATEACSALAGVFSPGKASRNQYQSSPeSHdSNTNASNDILNSSTKI
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP21260 with Med12 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) PGCEECKRAKRQKVSDERSSYIQGNSPIPSDDEDTWWMRKRLKSLEPMKVDPPVKSTKQVSRNRQKIVRK
2) TRGTNKQAGPAPSGVEGPTSKGNNRKGIRGGSPG
3) TSHVCNNKVSCPHHRTGLEGETPKSTDPTKVSH
168
1222
257
237
1255
289










Molecular Recognition Features






MoRF SequenceStartStop




1) DTWWMRKRLKSL
2) YIGAVDD
201
1546
212
1552