<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP21251

Description Mediator of RNA polymerase II transcription subunit 16
SequenceMSQVKESDDEPVALSLESDKPEIGSIESIEEDEEEEEEEEPVDKPGDPMEEDSISPAAVFCIRLKQPRSNLQHKMSVPELCRNFSAVAWCGKLNAIACASETCARIPSSNANPPFWIPIHIVIPERPTECAVFNVNADSPRDSVQFIEWSPTSCPRALLIANFHGRITIWTQPSQGPANLVRDASRWQREHEWQQDIAVVTKWLSGVSPYRWLSSKSSAASNAKSTFEEKFLSQQSQNSARWPNFLCVCSVFSSGSVQLHWSQWPPNQNSAAPKWFQTSKGLLGAGPSGIMAADAIITDSGAMHVAGVPIVNPSTVVVWEVTPGLGNGFQVTPKISTSNGVPPSLNPPNWAGFSPLAAYLFSWQDYLISEAKQGRKQTDPDFSDTVPLHCSPVSNFSAYVSPEAAAQSATTTTWGSGVTAVAFDPTRGGSVIAVVIVEGQYMSPYDPDEGPSITGWRVQRWESSLQTVVLHQIFGNPTSSFGGQAPMQTVWLSKVDTSIQPTNDFKSHQAAASGATSDARKTTDSSLEKSKRVSFDPFDLPSDVRTLARIVYSAHGGEIAVAFLRGGVHIFSGPNFAPVDNYQINVGSAIATPAFSSTSCCSASVWHDSGKDRTVLKIIRVLPPAVSSSQVKANSSTWERAIAERFWWSLLVGVDWWDAVGCTQSAAEDGIVYLNSVIAVLDADFHSLPSTQHRQQYGPSLDRIKCRLLEGTNAQEVRAMVLDMQARLLLDMLGKGIESALINPSALVAEPWQASGETLSGIDPEAMAVEPALVPNIQAYVDAVLDLASHFITRLRRYASFCRTLASHAGSAGTGSNRNMVASPTQSSASPATSQAGQSGTTTSTGNTQMQAWVQGAIAKISSTSDGVPNSTPNPISGPSSFMPISINTGTFPGTPAVRLIGDCHFLHRLCQLLLFCFFFRRTQLPRFVGGAQRNTDANMQKPQPGAPGKVEEVSSVTVKSSSTMVRQDEGQVARAGQIIPGAKGAEEGPAGRSRLGAGNAGQGYTFEEVKVLFLILMDLCRRTATLAHPLPVSQVGSSNIQVRLHYIDGNYTVLPEVVEASLGPHMQNMPRPRGADAAGLLLRELELHPPAEEWHRRNMYGGPWSDPDDMGPQDDTPKLCNSADPLGSNSLESCEVYYGAHGLWPRKRRMSERDAAFGLNTSVGLGAYLGIMGSRRDVVTAVWKTGLEGVWYKCIRCLRQTSAFASPGATSRPNQTGRETWWISRWAYCCPMCGGTWIGHTEAFVKAIILEDDPGFRVAGCKSSSPDLDLSISLVVRTSHLIYYCTRM
Length1289
PositionTail
OrganismPrunus yedoensis var. nudiflora
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> rosids> fabids> Rosales> Rosaceae> Amygdaloideae> Amygdaleae> Prunus.
Aromaticity0.08
Grand average of hydropathy-0.227
Instability index46.41
Isoelectric point5.82
Molecular weight139586.58
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process
regulation of transcription, DNA-templated	GO:0006355	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP21251
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     134.04|      29|     171|     393|     430|       1
---------------------------------------------------------------------------
  201-  222 (30.49/15.26)	..........TK........WLSGVSPYRW.LSSKSSAASN
  405-  430 (38.04/12.67)	AA...QSATTTT........WGSGVTAVAF.DPTRGGS...
  836-  870 (37.88/10.30)	AG...QSGTTTStgntqmqaWVQGA..IAK.ISSTSDGVPN
 1211- 1236 (27.63/ 6.76)	TSrpnQTGRETW........W...ISRWAYcCPMCGG....
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     188.67|      66|     171|     876|     948|       2
---------------------------------------------------------------------------
  572-  601 (27.34/ 9.68)	SGP.NFAPVdnyQINVGSAIATPAFSSTSCC...........................................................................................................................................................................................................................................
  790-  831 (45.17/ 9.58)	...............................sasvwhdsgkdrtvlkiirvlppavsssqvkansstweraiaerfwwsllvgvdwwdavgctqsaaedgivylnsviavldadfhslpstqhrqqygpsldrikcrllegtnaqevramvldmqarllldmlgkgiesalinpsalvaepwqasgetlsgidpeamavepalvpniqayvdavldlasHFITRLRRYASFC....RT.LASHAGSAGTGSNRNMvASPtQSSAsP
  877-  948 (116.16/92.96)	SGPsSFMPI...SINTGTFPGTPAVRLIGDC............................................................................................................................................................................................HFLHRLCQLLLFCfffrRTqLPRFVGGAQRNTDANM.QKP.QPGA.P
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      35.18|      10|      31|     307|     319|       5
---------------------------------------------------------------------------
  307-  319 (16.61/14.57)	GV.PIVNPSTvvvW
  340-  350 (18.57/ 7.91)	GVpPSLNPPN...W
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.86|      11|     659|     441|     451|       6
---------------------------------------------------------------------------
  441-  451 (26.02/10.77)	YMSPY.DPDE.GP
 1101- 1113 (18.84/ 6.03)	YGGPWsDPDDmGP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      32.02|      10|      21|      19|      32|       7
---------------------------------------------------------------------------
   19-   32 (10.29/16.80)	DKPeiGsiESIEED
   43-   52 (21.74/12.49)	DKP..G..DPMEED
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.17|      13|     655|     101|     118|       8
---------------------------------------------------------------------------
  101-  114 (20.97/20.55)	ETCArIPSSNANPP
  128-  140 (24.20/ 6.50)	TECA.VFNVNADSP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      79.60|      25|     574|     463|     488|      10
---------------------------------------------------------------------------
  463-  488 (42.90/28.65)	SSLQtVVLHQIFGN....PTSSFGGQAP.MQ
 1039- 1068 (36.69/19.66)	SNIQ.VRLHYIDGNytvlPEVVEASLGPhMQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      83.31|      22|     536|     640|     662|      11
---------------------------------------------------------------------------
  640-  662 (40.27/31.13)	RAIAERFWWSLLVGVdWWDAVGC
 1177- 1198 (43.04/28.07)	RDVVTAVWKTGLEGV.WYKCIRC
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP21251 with Med16 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) GTGSNRNMVASPTQSSASPATSQAGQSGTTTSTGNTQ
2) MSQVKESDDEPVALSLESDKPEIGSIESIEEDEEEEEEEEPVDKPGDPMEE
813
1
849
51










Molecular Recognition Features






MoRF SequenceStartStop




1) MSQVKESDDEPVALSLESDKPEIGSIESIEEDEEEEEEEE
1
40