<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP21241

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMASELGQQTVEFSTLVNRTAEESFLSLKELVEKSKAAPDQSDTDKKIGLLKYLAKTQQRMLRLNVLAKWCQQVPLIQYCQQLSSTLSSHDTCFTQAADSLFFMHEGLQQACAPVYDVPSAIDILLTGSYQRLPKCVEDVGVQSSLSEDKQKPALKKLDTLVRSKLLEVSLPKEISEVKVSDGTAVLRVNGEFKVLVTLGYRGHLSMWRILHLELLVGERCGLVKLEESRRHALGDDLERRMAAAENPFMTLYSVLHELCVALVMDTVIRQVQALRQGRWKDAIRFELISDGSTSHGGSSASAQLNQDGENDSSGLRTPGLKILYWLDFDKNNGISDSASCPSIKIEPGPDLQIKCLHSTFVIDPLTGKEAEISLDQNCIDVEKLLLRAICCNRYTRLLEIQKDLGKNAQIYRGKGDVSLESHVEDMDVDHKKVVSLFLVTCFWNGRFRLQSSPNILASPEFLSECEDALNQGSMTAAEVFINLRSKSILHLFASIGRFLGLEVYEHGFPAVKVPKNILNGSTELLMGFPDCGNSYFLLMQLDKDFKPLFKLLETQPGPSGKADSCHDLNHVIRIKKIDVSQMQMHEDDMNLSLLDWGKLHSFLPSAGGSNRSSENGLLSDISPGGSMPIAGCAPSSFSSVVDEVFELEKGLSVPSYSIPNVSSSLNASPASHFGSGPMNLHTIKAGSASPKWEGGMQLSQLNNSANVSSMATHYNGSLYSSNNLKGPIQSASLGSLSSGPGRSASVKKIPISKSDQDLASLRSPQSVEYGSCTSMDEDQLRFLNDTSKGALYGNRSSQILSPTRSTGPRISGPGVRPNGPITGSFRVAGLNSSATTPGSQAPDSGVCHSPNQDVSNRKPRKRTLSDMLNLIPSLQCVEANSGFCRRRKISEVARPQQSSSQMLMSRDIISKSDVYSYGDLISEANKGNAPSSIYVSALLHVVRHCSLGIKHARLTSQMGALDIPYVEEVGLRSISSNIWFRLPFARGDSWQHLCLRLGRPGSIYWDVKINDQHFRDLWELQKGNGTPWGSGVRIANTSDIDSHIRYDPEGVVLSYQSVEADSIKKLVADIQRLSNARMFALGMRKLLGVRADEKPEESNTHSDFKAPGVKGSFEAADRLSEQMRRAFRIEAVGLMSLWFSFGSGVLARFVVEWESGKEGCTMHVSPDQLWPHTKFLEDFINGAEVASLLDCIRLTAGPLHALAAATRPARASPIPGVPGGAVLSSIPKLGGQSPSQGLMPASSTTNASQSPSGPMGNPVSSTATGPLANHSLHGAAVLAAAGRGGPGIVPSSLLPIDVSVVLRGPYWIRIIYRKHFAVDMRCFAGDQVWLQPATPPKGGPSVGGSLPCPQFRPFIMEHVAQELNGLDTNFTAGQQTGLASSINQNPTSGSQLSLQPSTVLNRVGNASPVSSNLAVVSSGMPLRRSPGPGVPAHVRGELNTAIIGLGDDGGYGGGWVPLVALKKVLRGILKYLGVLWLFAQLPDLLKEILGSILKDNEGALLNLDQEQPALRFFVGGYVFAVSVHRVQLLLQVLSVKRFHHQQQQQQQQQQPNSTTAQEELSPSEIAEICDYFSRRVASEPYDASRVASFITLLTLPISVLREFLKLIAWKKGLAQAQGGDGAPAQKPRIELCLENHAGSSMDENSDNSSVAKSNIHYDRPHNSVDFALTLVLDPAHIPHINAAGGAAWLPYCVSVRLRYAFGENPNVSFLGMEGSHGGRACWLRIDDWEKCKLKVARTVELNGSSGGDSSQGRLRIVADCVQRTLHMWLQGLRDGGGVSASSGAT
Length1785
PositionTail
OrganismPrunus yedoensis var. nudiflora
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> rosids> fabids> Rosales> Rosaceae> Amygdaloideae> Amygdaleae> Prunus.
Aromaticity0.06
Grand average of hydropathy-0.201
Instability index46.34
Isoelectric point7.69
Molecular weight193654.09
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU365082

GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP21241
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     171.43|      45|     212|    1196|    1240|       1
---------------------------------------------------------------------------
  649-  696 (51.56/21.88)	KGlsvPSYSIPNVSSSLNASPAShfgSGPM...N..LHTI.KAGSASP.KwEGGM.
 1196- 1240 (80.69/38.50)	AG...PLHALAAATRPARASPIP...GVPG...GAVLSSIPKLGGQSP.S.QGLMP
 1421- 1457 (39.17/14.81)	...............PLRRSPGP...GVPAhvrGELNTAIIGLGDDGGyG.GGWVP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     131.16|      32|      36|     837|     868|       2
---------------------------------------------------------------------------
  595-  622 (32.39/13.23)	........DWGKLHSflPSAGGSN.RSSENGLLSDIS
  837-  868 (60.58/31.18)	PGSQ..APDSGVCHS..PNQDVSN.RKPRKRTLSDML
  872-  903 (38.20/16.93)	PSLQcvEANSGFCR....RRKISEvARPQQSS.SQML
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.17|      15|      36|     724|     738|       3
---------------------------------------------------------------------------
  724-  738 (26.33/16.52)	LKGPIQSA..SLGSLSS
  747-  763 (18.84/ 9.24)	KKIPISKSdqDLASLRS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     117.88|      27|      36|     977|    1003|       4
---------------------------------------------------------------------------
  977- 1003 (51.82/27.74)	NIWFRLPFARGDSWQHLCLRLGRPGSI
 1016- 1040 (44.36/22.69)	DLW.ELQKGNGTPWGS.GVRIANTSDI
 1722- 1738 (21.70/ 7.36)	..WLRI.....DDWEKCKLKVART...
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      35.67|      10|      36|     132|     141|       5
---------------------------------------------------------------------------
  132-  141 (18.79/12.34)	LPKCVEDVGV
  170-  179 (16.88/10.29)	LPKEISEVKV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     102.65|      33|      36|     327|     362|       6
---------------------------------------------------------------------------
  312-  346 (51.78/48.11)	SSGLRTPGLKILYWLD..FDKNNGISDSASCpsIKIE
  348-  382 (50.87/33.02)	GPDLQIKCLHSTFVIDplTGKEAEISLDQNC..IDVE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      79.91|      25|     392|     765|     790|       7
---------------------------------------------------------------------------
  765-  790 (43.14/28.14)	QSVEYGsCT.SMDEDQL....RFLNDTSKGA
 1154- 1183 (36.77/19.37)	ESGKEG.CTmHVSPDQLwphtKFLEDFINGA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      88.83|      25|     746|     624|     648|       8
---------------------------------------------------------------------------
  624-  648 (43.85/23.69)	GGSMPIAGCAPSSFSSVVDEVFELE
 1343- 1367 (44.99/24.51)	GGSLPCPQFRPFIMEHVAQELNGLD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      59.44|      16|      36|    1251|    1266|       9
---------------------------------------------------------------------------
 1251- 1266 (31.21/15.86)	PSGPMGNPVSSTATGP
 1290- 1305 (28.23/13.64)	PSSLLPIDVSVVLRGP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP21241 with Med14 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) GNRSSQILSPTRSTGPRISGPGVRPNGPITGSFRVAGLNSSATTPGSQAPDSGVCHSPNQDVSNRKPRKRTL
2) GRSASVKKIPISKSDQDLASLRSPQSVEYGSCTSM
3) PSQGLMPASSTTNASQSPSGPMGNPVSSTATGP
793
741
1234
864
775
1266










Molecular Recognition Features






MoRF SequenceStartStop




NANANA