<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP21222

Description Eukaryotic translation initiation factor 3 subunit C
SequenceMESRFWNQTGSDSEDADSEYDEEAEATSVETSKQIDNKYRTNVLPDDESEDEKRVVRSVKDKRFDEMSATVDKIKNAKNINDWVSMQDCFDKMNKQLEKVMRVTESEKVPSLYIKALVLLEDFLAQALANKDAKKDAKKKMSSSNAKALNTMKQKLKKNNKQYEDLICKYRENPEQSEEEGGAEDEESENEETDSEIEDPKDIALSVSGDGDEEEEGDGDNEDGVEKKMSKKDKLMDKQFMKDPSEITWDMINKKFKEVVAARGRKGTGRFEQVEQLTFLTKVAKTPAQKLEILFSLVSAQFDVNPGLSGHMPINVWKKCVQNMLVILDILVQYPNITVDDMIEPDENESQKGPDYNETIRVWGNLVAFVERIDTEFFKSLQCIDPHTHEYIERLRDEPMFLTLAQNVQKYLEKAGSFKAAAKVALRRVELVYYKPQEVYAAMKILAEQTEDGETGGEGQEPKAVEESRGPPAFVVTPELVPRKPTFTESSRALMDILVSLIYKYGDDRTKARAMLCDIYHHALLDEFSIARDLMLMSHLQDSISHMDISTQILFNRAMAQLGLCAFRSGLIPEGHSCLSELYSGGRVKELLAQGVSQSRYHEKTPEQERLERRRQMPYHMHINPELLEAVHLICAMLLEVPNMAANIHDTKRRVISKTFRRFLEMNEKQTFTGPPENVRDHVMAATRALSKGDFEKAFKVISSLHVWKLLRKHESVLEMLKAKIKEEALRTYLLTYSPAYKTLSLAQLTQMFELSEAQAHCIVSKMMINDELRASWDQPTHCIVFHDVEHTRLQDLAFQLTEKLSIIAESNERATELRIGGGALEPLRRRDSQDYGAGTTAVSGRWQDNLSYTQGRQGGASGRTGYRSMAYGQAAGGYSRDRTGTGQYRGTGHNTRYQDAAHGGSGRAGYHAGSSARGSQMDTSTRLFSSRSRFFEFRFGQKVLAMATATYPPPPPYYKLYKDYLQDPKSAPEPPPPIEGTYVCYGGNYTTYDILPSLEDQGVRQLYPKGPNIDFKKELRSLNRELQLHILELADILVERPSQYARRVEDISLIFKNLHHLLNSLRPHQARATLIHILELQIQRRKQAVEDIKRRREEAQRLLKESIGTLEDTGASFVLK
Length1121
PositionMiddle
OrganismPrunus yedoensis var. nudiflora
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> rosids> fabids> Rosales> Rosaceae> Amygdaloideae> Amygdaleae> Prunus.
Aromaticity0.07
Grand average of hydropathy-0.649
Instability index54.08
Isoelectric point5.93
Molecular weight127738.16
Publications









Function






Annotated function

Component of the eukaryotic translation initiation factor 3
(eIF-3) complex, which is involved in protein synthesis of a
specialized repertoire of mRNAs and, together with other initiation
factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S
ribosome. The eIF-3 complex specifically targets and initiates
translation of a subset of mRNAs involved in cell proliferation.



ECO:0000256	HAMAP-Rule:MF_03002

GO - Cellular Component
eukaryotic 43S preinitiation complex	GO:0016282	IEA:UniProtKB-UniRule
eukaryotic 48S preinitiation complex	GO:0033290	IEA:UniProtKB-UniRule
eukaryotic translation initiation factor 3 complex	GO:0005852	IEA:UniProtKB-UniRule
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
translation initiation factor activity	GO:0003743	IEA:UniProtKB-UniRule
translation initiation factor binding	GO:0031369	IEA:InterPro

GO - Biological Process
formation of cytoplasmic translation initiation complex	GO:0001732	IEA:UniProtKB-UniRule
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP21222
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      91.65|      18|      20|     851|     868|       1
---------------------------------------------------------------------------
  851-  868 (34.04/17.69)	LSYTQGRQGGASGRTG...YR
  870-  890 (26.46/12.29)	MAYGQAAGGYSRDRTGtgqYR
  896-  912 (31.15/15.63)	TRYQDAAHGG.SGRAG...YH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.52|      12|      20|     954|     965|       2
---------------------------------------------------------------------------
  954-  965 (27.17/14.02)	PPPPYYKLYKDY
  975-  986 (27.35/14.16)	PPPPIEGTYVCY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      66.39|      22|      44|    1025|    1052|       3
---------------------------------------------------------------------------
 1025- 1052 (28.21/34.84)	RELQLHILELAdilVERPSQyarRVEDI
 1072- 1093 (38.18/24.99)	RATLIHILELQ...IQRRKQ...AVEDI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      99.45|      32|      43|     172|     203|       4
---------------------------------------------------------------------------
  172-  203 (53.40/29.95)	ENPEQSEEEGGAEDEESENEE.TDSE.IEDPKDI
  214-  247 (46.05/24.83)	EEEGDGDNEDGVEKKMSKKDKlMDKQfMKDPSEI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.17|      14|      19|     492|     508|       6
---------------------------------------------------------------------------
  492-  505 (22.53/16.49)	RALMDILVSLIYKY
  509-  522 (25.64/ 9.87)	RTKARAMLCDIYHH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      38.12|      10|      18|     598|     607|       7
---------------------------------------------------------------------------
  598-  607 (19.77/10.34)	QSRYHEK.TPE
  616-  626 (18.35/ 9.11)	QMPYHMHiNPE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.92|      21|      44|      17|      37|       8
---------------------------------------------------------------------------
   17-   37 (34.30/21.57)	DSEYDE.EAEATSVETSKQIDN
   61-   82 (28.62/16.81)	DKRFDEmSATVDKIKNAKNIND
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      66.57|      19|      45|     303|     321|       9
---------------------------------------------------------------------------
  303-  321 (37.64/28.94)	DVNPGLSG...HMPINVWKKCV
  346-  367 (28.93/20.39)	DENESQKGpdyNETIRVWGNLV
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP21222 with Med7 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) EDLICKYRENPEQSEEEGGAEDEESENEETDSEIEDPKDIALSVSGDGDEEEEGDGDNEDGVEKKMSKKDKLMD
2) MESRFWNQTGSDSEDADSEYDEEAEATSVETSKQIDNKYRTNVLPDDESEDEKRVVRSV
3) YGQAAGGYSRDRTGTGQYRGTGHNTRYQDAAHGGSGRAGYHAGSSARGSQMDT
164
1
872
237
59
924










Molecular Recognition Features






MoRF SequenceStartStop




1) PYYKLYKDYLQDPK
957
970