<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP21193

Description Mediator of rna polymerase ii transcription subunit 15a
SequenceMDGNNRRAAQGNAPAAGAMDTADWRTQLQPDSRQRIVNKIMENIKGRLPVSGHEGAQELNKIAMRFEDMIHTAATSKQDYLQRFSKMLTKLTKFQYPDSIQPNAITSGQNAHGPGSHSMHSQVNSQAQQLPVPMVANETQTKQPLLLQNIQNNMASQNCVSLSPALPPVGNLTQATMPNVVGQNSNFQTMPNVGQVVPPDLVSNSQRQMQGRQQQVASQQQQQQFQTTQQFYQQQLHRQMMKKKFQQGNTPQSLIQHEQQKQQPQSQEEQQQQRQNLLQPTQRNQQQFGSQSNIAGIQQQQLTESQPVNSGLSCNRHPIHILQLSKIPVQRQTLQSAATVLPSQHQQSQSHPVQQQMTSQSQSRPPLGLQQQKNQLPREMQQSIQVSSPLLQHQKELYQLQRATPEASSTSLDSTVLRGNAIGADWQEEVYQKIKFMKEMYLSKLNYLYQKIASKMQQLDSLPQRPQNEQIETFKMLKITLGHILLFLRLNKQDIKLFHKEKLLQVEKHIGLFLSSDRPRTPTLSLQQGQLPEALRMQLKVQSSMEAMQQNNLTKLQHNSFSPQVTQHPSPQTDEQNMLASLTKAGPPLQSANSPFVVPSPSTSWDLSPMPGDSEKVSTGLASHIAAGNITHQQADAPDQSVGIGIPEISASPLLAEFTCLDGTHANVSAVVSGKSSVEQSLERLMKVVKNMSPKALNSSISDISSVVSMMDRTAGSAPGNGSRATVGEDLVAMTKCRLQATNYSAQDGLPGAKKLKRHRTSDVVSSCGNVNDSFWQLNGSEVSESESTATSSFKIPRPEVNHALVEEIRNINRQLIDTVVEISDEGVDPSDVASATEGGEGTTVKCSFTSVALSPSLKSQYASAQMSQIQPLRLLVPANYPDCSLILLDEFPVEVSKKYEDHSMKAKSRFGVFLRNFSQPMSLKDIAKTWDVCARSVISECAQQNGGGTFSSKYGSWENCLSTA
Length965
PositionTail
OrganismNicotiana attenuata (Coyote tobacco)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> asterids> lamiids> Solanales> Solanaceae> Nicotianoideae> Nicotianeae> Nicotiana.
Aromaticity0.04
Grand average of hydropathy-0.623
Instability index65.74
Isoelectric point8.90
Molecular weight106739.06
Publications









Function






Annotated function


GO - Cellular Component
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
chromatin DNA binding	GO:0031490	IEA:InterPro
transcription coactivator activity	GO:0003713	IEA:InterPro

GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP21193
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      84.12|      21|      21|     247|     267|       2
---------------------------------------------------------------------------
  253-  275 (30.58/ 9.89)	SLIQHEQQKQQPQSQeeQQQ.QRQ
  292-  312 (29.31/ 9.14)	SNIAGIQQQQLTESQ..PVN.SGL
  543-  564 (24.23/ 6.18)	SSMEAMQQNNLTKLQ..HNSfSPQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     116.21|      28|      74|     316|     343|       3
---------------------------------------------------------------------------
  316-  343 (48.71/24.22)	RHPIHILQLSKIPVQR...QTLQSAATVLPS
  364-  391 (30.41/12.18)	RPPLG.LQQQKNQLPRemqQSIQVSSPLL..
  392-  414 (37.10/16.58)	QHQKELYQL.....QR...ATPEASSTSLDS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      72.38|      22|      30|     565|     591|       4
---------------------------------------------------------------------------
  565-  586 (39.77/15.16)	VTQHPSPQTDEQNM..........LASLTKAG
  597-  628 (32.62/17.38)	VVPSPSTSWDLSPMpgdsekvstgLASHIAAG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      59.59|      15|      16|      65|      79|       5
---------------------------------------------------------------------------
   65-   79 (27.42/19.20)	RFEDMIH.TAATSKQD
   83-   95 (16.97/ 8.83)	RFSKML..TKLTKFQ.
   96-  110 (15.20/ 7.08)	.YPDSIQpNAITSGQN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     103.32|      31|      57|     119|     154|       6
---------------------------------------------------------------------------
  119-  154 (50.22/36.27)	MHSQV..NSQAQQLPvpmvaNETQTKQPLLLQNIQNNM
  177-  209 (53.11/27.94)	MPNVVgqNSNFQTMP.....NVGQVVPPDLVSNSQRQM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.42|      18|      56|     705|     723|       7
---------------------------------------------------------------------------
  691-  708 (27.29/15.63)	NMSPKALNSSISDISSVV
  710-  727 (30.13/13.09)	MMDRTAGSAPGNGSRATV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.49|      17|     399|      22|      44|       8
---------------------------------------------------------------------------
   22-   44 (22.55/27.68)	ADWrtqlQPDSRQRIvnKIMENI
  424-  440 (32.94/19.36)	ADW....QEEVYQKI..KFMKEM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     101.61|      24|      24|     465|     488|      14
---------------------------------------------------------------------------
  466-  489 (40.75/28.33)	PQNEQIETF...KMLKITLGHILLFLR
  490-  515 (29.31/18.12)	LNKQDIKLFhkeKLLQVE.KHIGLFLS
  516-  536 (31.55/20.12)	SDRPRTPT......LSLQQGQLPEALR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.28|      14|      16|     762|     777|      15
---------------------------------------------------------------------------
  762-  775 (24.95/19.12)	SDVVSSCGNVNDSF
  781-  794 (22.32/ 8.07)	SEVSESESTATSSF
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP21193 with Med15 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) DSIQPNAITSGQNAHGPGSHSMHSQVNSQAQQLPVPMVANETQTKQPLLLQNI
2) EAMQQNNLTKLQHNSFSPQVTQHPSPQTDEQNMLASLTKAG
3) LHRQMMKKKFQQGNTPQSLIQHEQQKQQPQSQEEQQQQRQNLLQPTQRNQQQFGSQSNIAGIQQQQLTESQPVNSGLSCNRH
4) LQSANSPFVVPSPSTSWDLSPMPGDSEKVSTGLASHIAAGNITHQQADAPDQSVGI
5) MDGNNRRAAQGNAPAAGAMDTADWRTQLQPDSRQRIVNKIMENIKGRLPVSGHEGAQELNKIAMRFED
6) QNCVSLSPALPPVGNLTQATMPNVVGQNSNFQTMPNVGQVVPPDLVSNSQRQMQGRQQQVASQQQ
7) TLQSAATVLPSQHQQSQSHPVQQQMTSQSQSRPPLGLQQQKNQLPREMQQSIQ
98
546
236
589
1
157
333
150
586
317
644
68
221
385










Molecular Recognition Features






MoRF SequenceStartStop




NANANA