<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP21192

Description Mediator of rna polymerase ii transcription subunit 33a
SequenceMAPMVSSVQIQSNLWDGVMELTKSAQQKGTDPLMWAIQLSSNLNSAGLSMPSTDVANLLVSHICWANNVPIAWKFLEKALTLRVVPPMFVLALLSTRVIPARRSYPVAYRLYMELLKRYAFSLASLINGPNYQKIMEAINDALHLYQIFGLQGSESGLIVVEFVFAIVWELLDASLDDEGLMELTAEKKSRWPITSQDMGLNNHDGFAGGRTEKHEGLCKMNTVMAIEIIGEFFRDKVTSAILYLARKNMPGHWESFTQNLRLLVSNSSALRNSKNISPEALLQLTSDNHVVLSRKRKTSSQKKFHAVVASGSLASSADQCHGASPSVLWLPFDLFLEDTIDGSQVAATSAAETLTGLVKALQAVNSTTWQDTFLGLWIAALRLVNRERDPSEGPVPRLDTCLCLLLSITPLAIANLIEEEERNCSSTNQTKESSRKRHQDLLSSLQQLDDYEGLLTPPLPAAPLANQAAAKAMMFLSGLRVGSGYFEGMSLNDMPVNCAGNLRHLIVEACIARNILDTSAYLWPGYVKGRCDQVPRSVSGQMPGWSSLMKGSPLTPPMVSSLVSTPASSLAEIEKIYDIAVNGSDDDKISAATILCGASLARGWNIQEHTVLFITRLLSPPVPANYSGTESHLIGYARFLNVLLIGVSSIDCVQIFSLHGLVPQLAGALMPICEAFGSCAPNVTWIVMSEEISSHAIFSNAFTLLLKLWRFDQPPRENVMDVVPVGSRLTPEYLLLVRNSQLASSDDLQKDQSKIKRLSRLSSPLSGEPIFMDSFPKLKLWYRQHQACIGSPLSGLLPGTPVHQIVEALLNFMFRKINRTGQSLAPTTSGSSSSSGPGNEDVFLHLKLPAWDILEAVPFVLDAALTACAHGRLSPRELATGLKDLADFLPASLATMVSYFSAEVTRGIWKLASMNGTDWPSPAANLATVEQQIKKILAATGVNVPSLTVGGNSPATLPLPLAALVSLTITYKLDRSTDRFLNLMGPALSNLATACPWPCMPVMVALWAQKVKRWSDFLVFSASRTVFHHNSDAVVQLLRMCFAATLGLTTSSIASNGGVGALLGHGFGSHFSGGISPVAPGILYLRVHRAVRNAMFMTEEVVSLLMHFVRDIASSGLPAEKLEKLKKSKYGMRYGQVSLAAAMTRVKLAASLGASLVWITGGVALVQSLIKETLPSWFISAHGSEPSGGMSGGLVAMLGGYALAYFAVLSGTFAWGVDSSSPASKHRSIILGGHLEFLASALDGKISLGCNKATWRAYVSGFVSLMVGSTPGWMLEVDVDVLKRLSTGLKQWNEEELALALLGSSGVGAMGTAAEMIIESGFNFVR
Length1327
PositionTail
OrganismNicotiana attenuata (Coyote tobacco)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> asterids> lamiids> Solanales> Solanaceae> Nicotianoideae> Nicotianeae> Nicotiana.
Aromaticity0.07
Grand average of hydropathy0.172
Instability index46.73
Isoelectric point7.57
Molecular weight143413.21
Publications









Function






Annotated function


GO - Cellular Component
integral component of membrane	GO:0016021	IEA:UniProtKB-KW
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process
regulation of phenylpropanoid metabolic process	GO:2000762	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP21192
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      99.46|      30|      32|    1182|    1212|       1
---------------------------------------------------------------------------
 1182- 1212 (50.71/37.42)	AHGSEPSGGMSGGLVAMLGGYaLAYFA.VLSG
 1215- 1245 (48.75/30.79)	AWGVDSSSPASKHRSIILGGH.LEFLAsALDG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     126.04|      33|      33|     682|     714|       2
---------------------------------------------------------------------------
  682-  714 (60.85/37.74)	P..NVTWIVMSEEISSHAIFSNAFTLLLK...LW.RFD..Q
  716-  750 (30.70/15.19)	PreNVMDVV...PVGSR..LTPEYLLLVRnsqLA.SSDdlQ
  762-  787 (34.50/18.03)	.........LSSPLSGEPIFMDSFP.KLK...LWyRQH..Q
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.06|      12|      29|       3|      14|       3
---------------------------------------------------------------------------
    3-   14 (21.31/ 9.73)	PMVSSVQIQSNL
   32-   43 (22.76/10.81)	PLMWAIQLSSNL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      90.25|      27|      34|      51|      83|       4
---------------------------------------------------------------------------
   51-   77 (50.25/41.26)	PSTDVANLLVSHICWA.NNVPIAWK.FLE
   86-  114 (40.01/19.64)	PPMFVLALLSTRVIPArRSYPVAYRlYME
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      39.68|      11|      30|     338|     348|       5
---------------------------------------------------------------------------
  338-  348 (18.87/10.15)	EDTIDGSQVAA
  371-  381 (20.81/11.94)	QDTFLGLWIAA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      88.42|      26|      34|     442|     467|       6
---------------------------------------------------------------------------
  442-  467 (44.86/22.38)	LLSSLQQLDDY.EGLLTPPLPAAPLAN
  476-  502 (43.56/21.54)	FLSGLRVGSGYfEGMSLNDMPVNCAGN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     157.69|      28|      29|     864|     891|       7
---------------------------------------------------------------------------
  862-  889 (44.25/19.76)	LD..............AALTACAH.......GRLSPREL...ATGLKDLADF
  890-  915 (38.87/16.58)	LP..............ASL.ATMV.......SYFSA.EV...TRGIWKLASM
  920-  957 (22.72/ 7.04)	WPspaanlatveqqikKILAAT.........GVNVP.SL...TVGGNSPAT.
  958-  995 (27.45/ 9.84)	LP..............LPLAALVSltityklDRSTDRFLnlmGPALSNLATA
  996- 1018 (24.40/ 8.03)	CP..........wpcmPVMVAL................W...AQKVKRWSDF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.09|      17|      25|     173|     189|      10
---------------------------------------------------------------------------
  173-  189 (27.43/21.61)	DASLDD.EGLMELTAEKK
  198-  215 (26.66/20.74)	DMGLNNhDGFAGGRTEKH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      74.78|      25|     524|     119|     153|      12
---------------------------------------------------------------------------
  119-  153 (28.78/66.97)	YAFSLASLINGpnyqkiMEAInDALhlyQIFGLQG
  637-  661 (46.00/43.84)	YARFLNVLLIG......VSSI.DCV...QIFSLHG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.68|      13|     524|     545|     557|      13
---------------------------------------------------------------------------
  545-  557 (26.88/14.61)	GWSSLMKG..SPLTP
 1067- 1081 (21.80/10.35)	GFGSHFSGgiSPVAP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP21192 with Med33 domain of Kingdom Viridiplantae
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