<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP21190

Description Mediator of rna polymerase ii transcription subunit 23
SequenceMLRAPTPTSHSNQATPEMEQPPPPPPQLRSSSSSSVFRSHHHHFHPSRPAILDLFNLYLGLKNSGQKSDDSIREPPKGELGFTFWSCTRALLITEEEKVYYTCNQHHFLLLFKKRTVVNQPELVRDYGPEVGNEANPVGTIGPRVSQLVLVSPFPAPSHFSSGFESVDETENSKADHVFDELPEKYENKDSLALFTGKQVFDEISHTTLAKLSNDSFCENVSLQTTVPAEVLDDMRGSNTKEEENSRHNVALFKNSPQKDLSGFLVPFARQGIMISNASARVAEIAYPIDGALWPRTISWLLNSLEGIRGGKQSRLSLYLIFGIHKCNWVDTGQERNLPGFLLSKSRGCARKDKIQGVLQAFAEGYSKQYIVFDHGPYLEYVTPYAVGSTFGDEKYVEEGTIKIRIELLAKKFPTGQGHDDLGGVELGVASCVTLKSSCATYKLLGESTENSLMQHFGGVTDHIVEQLNAPVLQSAICAYRNCNILAFSLESHFVGSDNKVILEYYGVAIVKDLTLVQVTSFMALLVDMYTNLEAMAHAQIICYDLPRRNPISLKFLIFDFDFDPKAQEEDSTRLFHQLMVVGVFLTNSILDAKQFEGSKILVIYRKLIWLLILGRLTDSKDPYFMNPLPHASILRKQFIRVDHNYKVLLRYNWWPHLGLIVYLQHYAHKLFISRLSKIHTKEHRALQCNIFLELRDKELLQHEEIGNLWIHGITYWSDLTLWLDVHNSFSFLESNLEDKVFFEDGSIVVNQPELVRDYGLEVGNEANPVGTIGPREIYRNKTQKRVTALNRELPPRNEQFVLDFGQLQSQFADQEQLRAVAESVLISLVIQCSSHAPHAEFLLFAICSLSSIGYINWDTFLPSLLSSVSSTEISASQGNQPSGAVSSANLTQSGLLPSSTAVASTSNFHSSNPASPLPTVHDVGSPVQSAAEPSSSAALSPMKSSDVNGTSQQSIAKVNLLTRDSAASSLRQTCCKIILTGLDSSLKPGTHAEVFHHMLNWLIYWDQKLHGVDEFDSAKYWKPDKALIEWLHSCLDVIWLLVENDKCRIPFYELLRSGLQFLENIPDDEALFTLILEIHRRRDMMAMHMQMLDQHLHCPTFGTPRLLPQATANSSGEAVTNMRYSPITYPSVLGEPLHGEDGVLGDSDTQKSSYNSLSYTLSRIRLLNHIGGIFMYAERLISVRSAASETMSDQEMKYDLAASIQKGSLDWERALRILKHALRNTPSPDWWRRVLLVAPCHRLHAQAPTPGAVFTSEMVCEAAIERIVELLKLTNSEINCWQEWLIFSDIFFFLVKSGCVDFVEFVDKLVLRLQEGDQQILRTNHVTWLLAQIIRVELVMNALNTDSRKVETTRKILSFHKEEKSSDPNNPQSILLDFISSCQNLRIWTLNTATREYLNNEQLQKGKQIDEWWRQVNKGERIMDYMNLDDRSIGMFWVVSYTMAQPACETVMHWLTSAGVTELLPGPNLQSNERLMVMREVSPLPISLLSGFSTNLCLKLAFQMEESMFSGQAVPSIAVVETYCRLMLISPHSLFRSLLTHLTSRNPTTLTKPGNTILVFEILNYRFLSLYRYQGKSKTLMYDVTKMISTLKGKRGDHRIFRLAENLCMNLILSLRDFFYVKREGKGPTEFTETLNRITIVTLAIIIKTRGIGEFDQLLYLQTMLEQILATSQHTWSEKTLHYFPSILRDALSGRMDKRGLAIQAWQQAETTVINQCTQLLSPSADPTYVMTYINHSFPQHRQYLCAGAWILMHGHPENINCINLGRVLREFSPEEVTANIYTMVDVLLHHIHLELQRGHPLQDLMLKACGNLSIFIWTHELLPPDILLLALIDRDDNPHALRIVINLLDSKELQQRVKLYLINRGPPEHWLSSGPFKRVELQKALGNYLSWKER
Length1896
PositionTail
OrganismNicotiana attenuata (Coyote tobacco)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> asterids> lamiids> Solanales> Solanaceae> Nicotianoideae> Nicotianeae> Nicotiana.
Aromaticity0.09
Grand average of hydropathy-0.176
Instability index45.20
Isoelectric point6.26
Molecular weight214974.74
Publications









Function






Annotated function


GO - Cellular Component
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP21190
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     144.41|      45|     262|    1489|    1535|       1
---------------------------------------------------------------------------
 1489- 1535 (73.52/60.19)	LLSGFSTNL.CLKLAFQMEEsmFSGQAVPS.....IAVVETYCRLMLISPHSL
 1753- 1803 (70.89/50.70)	LMHGHPENInCINLGRVLRE..FSPEEVTAniytmVDVLLHHIHLELQRGHPL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     278.89|      83|     427|     593|     757|       2
---------------------------------------------------------------------------
   37-  125 (139.82/50.55)	FRSHHHHFHPSRPAILDlFNLYLGLKNSGQKSDDSIreppkGEL...GFTFWSCTRALLITEEEKVYYTCNQHHFLLLFKKRTVVNQPELVR
  672-  757 (139.07/55.57)	FISRLSKIHTKEHRALQ.CNIFLELRDKELLQHEEI.....GNLwihGITYWSDLTLWLDVHNSFSFLESNLEDKVFFEDGSIVVNQPELVR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.43|      13|      33|     893|     905|       4
---------------------------------------------------------------------------
  893-  905 (22.46/13.60)	QSGLLPSSTAVAS
  929-  941 (21.97/13.13)	QSAAEPSSSAALS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      85.30|      19|     630|     126|     144|       7
---------------------------------------------------------------------------
  126-  144 (43.18/30.75)	DYGPEVGNEANPVGTIGPR
  758-  776 (42.12/29.80)	DYGLEVGNEANPVGTIGPR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     118.04|      39|     425|     593|     640|       8
---------------------------------------------------------------------------
  593-  640 (58.63/62.86)	AKQFEGSKILV..IYRKL..IWLLIlgrltdSKDPYfmnPLPHASILRK..QFI
 1019- 1063 (59.41/39.75)	AKYWKPDKALIewLHSCLdvIWLLV......ENDKC...RIPFYELLRSglQFL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP21190 with Med23 domain of Kingdom Viridiplantae
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