<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP21184

Description Cyclin-dependent kinase e-1
SequenceMGDGNTSSRGGNSNSSNRPEWLQHYDLIGKIGEGTYGLVFLAKIKANRSKSIAIKKFKQSKDGDGVSPTAIREIMLLREITHENVVKLVNVHINQADMSLYLAFDYAEHDLYEIIRHHRDKVNQAINQYTVKSLLWQLLNGLNYLHSNWIIHRDLKPSNILVMGDGEEHGVIKIADFGLARIYQAPLKPLAENGVVVTIWYRAPELLLGAKHYTSAVDMWAVGCIFAELLTLKPLFQGQEVKGTPNPFQLDQLDKIFKVLGHPTPEKWPTLVNLPHWQSDVQRIQGHKYDNPALYSVLHLSPKSPAYDLLSKMLEYDPRKRITAVQALEHEYFRMEPLPGRNALVPPQPGEKIVNYPIRPVDTTTDFEGTISLQPSQPVSSGNAASGGMQGPHVMPNRSVPRPMPMVNMQRMQPQGMSAYNLASQAGMGAGMNPGNMPMQRGVAAQAHQQQMRRKDPGMGLPGYPPQQKSRRF
Length473
PositionKinase
OrganismNicotiana attenuata (Coyote tobacco)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> asterids> lamiids> Solanales> Solanaceae> Nicotianoideae> Nicotianeae> Nicotiana.
Aromaticity0.08
Grand average of hydropathy-0.443
Instability index40.35
Isoelectric point9.35
Molecular weight52981.27
Publications









Function






Annotated function


GO - Cellular Component
GO - Biological Function
ATP binding	GO:0005524	IEA:UniProtKB-UniRule
protein serine/threonine kinase activity	GO:0004674	IEA:UniProtKB-KW

GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP21184
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     119.87|      26|      29|     410|     438|       1
---------------------------------------------------------------------------
  373-  396 (29.74/11.72)	...LQPsQPVSSGNAAS.GGMqG....PHVMP
  410-  438 (46.60/29.23)	QR.MQP.QGMSAYNLASQAGM.GAgmnPGNMP
  440-  466 (43.53/20.20)	QRgVAA.QAHQQQMRRKDPGM.GL...PGYPP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.20|      18|      31|      77|      95|       2
---------------------------------------------------------------------------
   77-   95 (27.27/24.94)	LREITHENVVKlVNVHINQ
  111-  128 (32.92/24.68)	LYEIIRHHRDK.VNQAINQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      63.21|      14|      24|     258|     271|       3
---------------------------------------------------------------------------
  258-  271 (25.78/12.77)	KVLGH..PTPEKWPTL
  283-  298 (18.57/ 7.36)	RIQGHkyDNPALYSVL
  299-  310 (18.87/ 7.58)	HL..S..PKSPAYDLL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP21184 with CDK8 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) TTDFEGTISLQPSQPVSSGNAASGGMQGPHVMPNRSVPRPMPMVNMQRMQPQGMSAYNLASQAGMGAGMNPGNMPMQRGVAAQAHQQQMRRKDPGMGLPGYPPQQKSRRF
364
473










Molecular Recognition Features






MoRF SequenceStartStop




1) KSIAIKKFK
2) QQMRRKDPGMGLPGYPPQQKSRRF
50
450
58
473