<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP21178

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMAELGQQTVDFSALVSRTAEESYATLNELVEKCKSSDLSDSEKKIGILKYIVKTQQRMLRLNVLSKWCQQVPLIQYCQQLASTLSSHETCFTQAADSLFFMHEGLQQARAPIYDVPSAVEVLLTGSYERLPKCIEDVGLQSVLNDNQQKPALKKLDALVRSKLLEVSLPKDITEVKVSDGTVLLRVDGEFKVLVTLGYRGHLSMWRILHMELLVGERSGPMKLDDFRRHALGDDLERRMAAADNPFMTLYSILHELCVALVMDTVIRQVQTLRHGRWKDAIRFELISDGSTGQGGSSGSAQISQNGESDSASLRTPGLKILYWLDLDKNSSTSEIGTCPFIKIEPGLDLRIKCLHSTFVIDPLTGKEAEFSLDQSCIDVEKLLLRVICCNRYTRLLEIYKELEKNGQICRVPGDVQLQCHVEEMLADSRKKDNKFDSREYQGQEVLRVRAFGSSFFTLAINIRNGHFILHSSKNVISSLVVVECEEALNQRSMSAADAFISLRSKSILHLFACIGRFLGLEVFEHGSAAVKVPKSISCGTNLLLMGFPECGSSYFLLMELDKDFKPVFKLLESQSDTPEKAQSLADLSNVVRVKTVDIGRMQICEDELNLSLLNSKKLLSILPNDGGSHQTSENSLLADFSLEGSIVSSSAPSTFCSIVDEIFELEKGSSVPSFSGQIPPSTFGASPAAHLGSGVANYQSLKVGTLSPKWDRGTGNYSSSMYKGVMQSGSAGSLATAPGRTQAVKKLTASKSEQDLTSLRSPHSAGAGSYTSLDEDQLTVSTNRSARLLSPPQRACPPASALSGKASAPRNSAVGAVPVGFRTFESNSLVLSPGSQAIDSATCLQSEQDAASRYNILPRKRTLSDLLDSLPSLQAMESNEGSYKRRKLVESAGTHLPKSLMLISSDISGKAEEYSYGSLIAEANKGNAPSSIYVSSLLHVVRHCSLCIKHARLTSQMEALEIPYVEEVGLRSASSNLWFRVPFARDDAWQHICLRLGRPGSMYWDVKINDQHFQDLWELQKGSNSTPWGSGVRIANTSDADSHIRYDSEGVVLSYYSVNADSIKKLVADIQRLSNARTFALGMRKLLGARADEKFEDSNANSENKALAAIKGASDATDRISEQMRKQFRIEAVGLMSLWFSFGSGVLARFVVEWEPGKEGCTMHVSPDQLWPHTKFLEDFINGAEVASLLDCIRLTAGPLHALAAATRPARAAPVSGVPGVTTPMSSVAKQTSYVPSLPSNVSTSINQPVSGPGVNPVSATVGALGTHHPSAAMLAAAAAAAGRGGPGIVPSSLLPIDVSVVLRGPYWIRIIYRKKFAVDMRCFAGDQVWLQPATPPKGGPEVGGSLPCPQFRPFIMEHVAQELNGIDSNFTGSQQAVGLTNSNSLNAGSQLPAANTNRTNLSNSTGLVRPANAVTGFNRTANGLPAASNLAMVNAGMPLRRPPGTGVPAHVRGELNTAIIGLGDDGGYGGGWVPLVALKKVLRGILKYLGVLWLFAQLPDLLKEILGSILKDNEGALLNLDQEQPALRFFVGGYVFAVSVHRVQLLLQVISVKRFHQSQQQSQQNPGSAQEELTQAEIGEICDYFSRRVASEPYDASRVASFITLLTLPISVLREFLKLIAWKKGLSQVQGGDMVPTQKSRIELCLENHAGCSIDGSSENTSASKSNIHYDRAHNSVDFALTVVLDHAHIPHINAAGGAAWLPYCVSVRLRYAFGENPNVLFLGMEGSHGGRACWLRVDDWERCRQRVARTVEVNGNSAGDANQGRLRVVADSVQRTLHAYLQGLRDGGGVAAGIGL
Length1798
PositionTail
OrganismNicotiana attenuata (Coyote tobacco)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> asterids> lamiids> Solanales> Solanaceae> Nicotianoideae> Nicotianeae> Nicotiana.
Aromaticity0.07
Grand average of hydropathy-0.135
Instability index44.34
Isoelectric point7.36
Molecular weight195123.95
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP21178
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     440.23|     137|     160|    1149|    1308|       1
---------------------------------------------------------------------------
  786-  842 (46.32/14.79)	............................................ARLLSPPQRA..................CPPASALSGKASAPRNSAVGAVPvGFRTFES....................NSLVLSPGSQAIdSAT........................................................
 1149- 1308 (208.51/165.52)	R..FVVEWEpgkegCtmhVSPDQLW..PHT..KFledfinGAEVASLLDCIRLT..................AGPLHALAAATRPARAAPVSGVP.GVTTPMSSVAKQTSYVPslPSNVSTSINQPVSGPGVNPV.SATvgaLgthhPSAAMLAAAAAA......AGRGGPGIVPSSLLPIDVSVVLRGPY...W
 1314- 1473 (185.40/103.92)	RkkFAVDMR.....C...FAGDQVWlqPATppKG......GPEVGGSLPCPQFRpfimehvaqelngidsnfTGSQQAVGLTNSNSLNAG.SQLP.AANTNRTNLSNSTGLVR..PANAVTGFNRTANG.............L....PAASNLAMVNAGmplrrpPGTGVPAHVRGELNTAIIGLGDDGGYgggW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     351.09|     120|     147|     244|     389|       2
---------------------------------------------------------------------------
  206-  338 (170.97/111.78)	RILHMELLVGERSGpmKLDDFRRHALGDDLERRM..AAADNPFMTLYSILHEL....CVALVMDTVIRQV...QTLRHGRWKDAiRFelisDGSTGQGgsSGSAQISQNGES...DSASLRTpGLKILYwldLDKNSSTSEIGT.C
  352-  484 (180.12/114.86)	KCLHSTFVIDPLTG..KEAEFSLDQSCIDVEKLLlrVICCNRYTRLLEIYKELekngQICRVPGDVQLQChveEMLADSRKKDN.KF....DSREYQG..QEVLRVRAFGSSfftLAINIRN.GHFILH...SSKNVISSLVVVeC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      73.88|      25|     160|     948|     979|       3
---------------------------------------------------------------------------
  948-  979 (36.18/41.78)	IKHA.....RLTSQM.EALEIpyvEEVGLRSassnLWF
 1110- 1140 (37.70/23.07)	IKGAsdatdRISEQMrKQFRI...EAVGLMS....LWF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     136.41|      41|     353|     660|     700|       4
---------------------------------------------------------------------------
  660-  700 (74.95/43.53)	DEIFELEKGS.SVPSFSG.QIPPSTFGASPAAHLGSGVA.NYQS
 1014- 1057 (61.46/34.28)	QDLWELQKGSnSTPWGSGvRIANTSDADSHIRYDSEGVVlSYYS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      85.53|      26|     415|      99|     156|       5
---------------------------------------------------------------------------
  130-  156 (41.24/15.91)	LPKCIEDVGLQSVLnDNQQKPALKKLD
  547-  572 (44.29/18.67)	FPECGSSYFLLMEL.DKDFKPVFKLLE
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP21178 with Med14 domain of Kingdom Viridiplantae
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