<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP21162

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMESLNTPEIQRSHTAKSQVWKPLIDVVDAVNCDAHDKLATFIHRQLPETGDTDRRKAFMLNYLLPQRNNWLKLKTLVSWSEKAGLVRDYEIHYKDVQRQKFISNEVEAKMREWSFHMPSSSLRSPDVTSSSDVLKEGTYKRFPSIIKECFAPDVLDDDKAKETLEALNGIIQIRMLTQEIIPKCMRNYRIMDGKIKFIVDKEFEAVLTPDNMEIDSHWWIIELKFLIQSASNKIFNDVKLSIHDKQISRLIETIQKQYLSPPQSPIPERISSSMKRPVGETLDATSLPQTAKFCPLVNLYEYLHNYCLDLQLNVLVQQAYYMRQTRWANNFDMSINDKDSVLKIYYWNYIKQALAVKSQSNIRPSEMEVNHDIIEISVITKESDRHLLYSSNKALKRSHWYTDTKYVKLGALNDIRGINYPHKFLRVRWTGLKGSEANEWIVIDWEFDPTNLNLEHLMLSVTQRHAQAVINKFVDILKNDEKGVYTEDDFEIVGGSNELVYDLESSESPSSDEVARKYLNVQKLRVLLCGDFKDCYINIGIDIHSGRIFIEDEKQEIDSDKIKACEDKLSYDHNKLVEVLIMLRSVVMISRLESMARKLFLDVPREIQLRPEDNMKLRTNQKIILEFNDAKDVNKMLSHEGINDKLNYLIVGLVESGIVYNLAELSRMPPSVKFLLSELVKEPSHKITSHRSIRLGNTIFDIEKLKADSHPMKYKYLNEYNHRKRNFDKMNEDEIGSTLSRPSKRTLDSSETDFNSFVIDELLLSRIVSIARSRIDYERIVTYFSEEVVKLEPIKPSDILRQIETAKCMSPEVDFDKSLDKSLDFLDANTPLSLSTIIPTFKISIKSLLARFPRANDLCLSIFSDVFVRLAGTRLTKMTNPEVILTTCLQSKYIPRMIEDFLHTNITYDQSSGILTFRYKYKNKKNFVKTFLKDFEEIVMMTQAASECKRILCDKKKNDINIIDYDFDTLKLQYDPYGVDISWRNDEYVLTLYVYGLGTELHAKEVFSNPYKDKLHAFLKEELNSAYIYNFDKFVDSLRIIPSVIRFLVNLSTKDNHACELQVIPKGATKFHLIWNYSIPPTGQKTWCGMDINFVPNKDETHFFASDLANLKEYRDLKPEKMPIWQAFEQELVNKQEIPLSKVQMFASGFTSPRANFEKIMEWIDEYVRKRAPWLNGVRS
Length1180
PositionTail
OrganismRhizophagus clarus
KingdomFungi
LineageEukaryota> Fungi> Fungi incertae sedis> Mucoromycota> Glomeromycotina> Glomeromycetes> Glomerales> Glomeraceae> Rhizophagus.
Aromaticity0.10
Grand average of hydropathy-0.406
Instability index45.41
Isoelectric point6.57
Molecular weight137551.35
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP21162
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     241.60|      67|      69|     435|     502|       1
---------------------------------------------------------------------------
  386-  420 (34.72/15.28)	......................HLLYS.........SNK........ALKRSH..WYTDTKYVKLGALNDirgINY
  434-  501 (108.60/68.82)	GSEANEWIVIDwEFDPTNLNLEHLMLSVTQRHAQAVINKFVD.....ILKNDEKGVYTEDDFEIVGGSNE...LVY
  502-  571 (98.28/56.81)	DLESSESPSSD.EVARKYLNVQKLRVLLCGDFKDCYINIGIDihsgrIFIEDEKQEIDSD..KIKACEDK...LSY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     196.42|      62|     341|     753|     817|       2
---------------------------------------------------------------------------
  753-  817 (94.02/81.57)	DF........NSFVIDELLLSRIVSIAR.SRIDyERIVTYFSEEVVKLEPIKPSDIlrQIETAKCMSPEVDFDK
  824-  883 (66.03/46.00)	DFldantplsLSTIIPTFKISIKSLLARfPRAN.DLCLSIFSDVFVRLAGTR.........LTKMTNPEV....
 1128- 1159 (36.37/21.23)	........................................FEQELVNKQEIPLSKV..QMFASGFTSPRANFEK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      94.15|      28|     341|     247|     275|       3
---------------------------------------------------------------------------
  247-  275 (45.36/36.10)	ISRLIETIQKQYLSPPQsPIPERISSSMK
  589-  616 (48.79/33.86)	ISRLESMARKLFLDVPR.EIQLRPEDNMK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     195.82|      65|     370|     630|     700|       6
---------------------------------------------------------------------------
  630-  700 (91.98/81.75)	AKDVnkmLSHEgINDKLNYLIVGLVESGIVYNLAELS...RMPPSV.KFLLsELVKEPSHkITSHRSIRLGNTIF
 1003- 1071 (103.84/68.68)	AKEV...FSNP.YKDKLHAFLKEELNSAYIYNFDKFVdslRIIPSViRFLV.NLSTKDNH.ACELQVIPKGATKF
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP21162 with Med14 domain of Kingdom Fungi
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