<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP21161

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMDSSSSTKISPIESTETNVLTVSNITKVGWYKYTYSCSGDKLRSFITSTPSPEVENLSRIDDPIVVNYMVLLEKGIPCTWKYKDENEKNFEILFTDKMLVRELYVFWLEDAEEHPPTLDNLIKLEGLEVTETGTFTWEDYESSAIQFDLFIRSIKNLISRTLIGKGAVPMGELHLFPKFQQKIYECILSCKYNIHITSTNLVVKPVVRYQSLRPLAPSDFSKSDEIKPEVVKVLLAPSGIRGNLLPYRRYEADDIAAVLNEFKTLFGLDLSNLEEESSIPTLVHVQITHDNLTKDFPYPAKGVYVITDSNNSYRCEARDSGMVPEIFNNFDYSSEQRLKPSKWWNYNDHSKEAVQILKLRNSGDLGTTSPGVDTMTPNTPGMGNGTSSASSPGHNLGTGRSSKKRPLETKAYPSPPDAIQTNEIQMPPPQNDTELTDDIMGMGVETYDYYMFEDDMLSHQVTEADFDTCDNKDSQTISPTTNDQTPSNISIVNEDSPSVGQNQISLAKNRQQQIDRDLQFDIGKVKLRYCPEDYIPLKFHDEVDMSKYMPGGKFCRATNRKKRKRGFFYTPDYEPAWVLEAKKPKTLDDDLKPRQKCKEKELERDSSESDTDDTGGSCESESESDIESDDESELEWKNEIVNSNVSNHRELGFLNAGRLSMIFNVYVLCERRQLRRLTDCEVCNDAQSELALQFLREQIAGGSYPFGAGIHGEGESTFEFIETRRRILENLSDDLPTSSALPSEQQEITTSLKNVIEEISVKFPRPENHPQLSVNGPLSVQEYYNLNGAQYKINEDAESNFQVLKTPDIIVCADKFLIETSPEIIKYWDKHNLTPFAGKKDVKYFVFCPEGESLYYHVKNFFSELRVQYELHCVLGMHEPGIIQNPNYNFKQGIIPIRLKPQNRNETELDRMIRSYKSTCEEFGSSLASYIGNFEKSQLVIYLINPFDHLTAYYDIFKCYAKFYTSLEKSLKSVSTKNILNYVMPQLIPIEHVVRFGENCIRPFRQRPVLKDLAFSVYTRSKSYRPLFILPKPSVVSVGFQLTKKAPPVRELIEYNKILHMSYGFSFDQRRLVMVWVDMEGKKLGSYSTPTYESKNQISLESLYKETWSRTCAFRKHTGGFKQIIITKTGVMTQEEKNLWIKVTEGKVPIFSVNLDTTLDIKPTPDGNGHSSKICGMVLNHPIPVNDFRPEATGFLVEMNNNETASNTIQVDLLYNPKIDKKNTEIIWDVLNQFHVLSFMEVTTTHMCLPIHVLMVERCCRVYLSVPS
Length1268
PositionKinase
OrganismRhizophagus clarus
KingdomFungi
LineageEukaryota> Fungi> Fungi incertae sedis> Mucoromycota> Glomeromycotina> Glomeromycetes> Glomerales> Glomeraceae> Rhizophagus.
Aromaticity0.10
Grand average of hydropathy-0.496
Instability index44.62
Isoelectric point5.40
Molecular weight144964.53
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



ECO:0000256	RuleBase:RU364134

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP21161
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     112.51|      40|     159|     392|     439|       1
---------------------------------------------------------------------------
  392-  438 (66.27/58.26)	PGHNL..GTGRSSKKRP............LETKaypsPPdaiQTNEIQMPPPQN..DTEL........TDD
  550-  613 (46.24/22.14)	PGGKFcrATNRKKRKRGffytpdyepawvLEAK....KP...KTLDDDLKPRQKckEKELerdssesdTDD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     156.75|      60|     162|     783|     861|       2
---------------------------------------------------------------------------
  783-  831 (51.55/50.88)	...............................YYNLnGAQYkiNEDAESNFQV..LKTPDIIVCADKFLieTSPEIIkyWDKH
  844-  861 (17.10/18.92)	YFVFCPE.GESLYYHVKNF...............................................................
  916-  968 (56.32/27.02)	YKSTCEEfGSSLASYIGNFeksqlviylinpFDHL.TAYY..................DIFKCYAKFY..TSLE........
 1202- 1231 (31.78/11.11)	..........................................NETASNTIQVdlLYNPKI....DK....KNTEII..WDVL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      85.58|      24|     811|     363|     388|       5
---------------------------------------------------------------------------
  364-  387 (46.32/22.88)	DLGTTSPGVDTMTPNTPGMGNGTS
  473-  496 (39.26/16.29)	DSQTISPTTNDQTPSNISIVNEDS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     114.92|      39|     811|     208|     249|       8
---------------------------------------------------------------------------
  208-  249 (64.10/48.72)	RYQSLRPL....APS....DFSKSDEIKP..EVV...KVLLAPSGIRgnlLPYRR
 1020- 1071 (50.82/30.54)	RSKSYRPLfilpKPSvvsvGFQLTKKAPPvrELIeynKILHMSYGFS...FDQRR
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP21161 with Med13 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) DDLKPRQKCKEKELERDSSESDTDDTGGSCESESESDIESDDESE
2) QILKLRNSGDLGTTSPGVDTMTPNTPGMGNGTSSASSPGHNLGTGRSSKKRPLETKAYPSPPDAIQTNEIQMPPPQNDTELTDDIM
3) VTEADFDTCDNKDSQTISPTTNDQTPSNISIVNEDSPSVGQNQISLAKNRQQQ
589
355
461
633
440
513










Molecular Recognition Features






MoRF SequenceStartStop




1) YDYYMF
447
452