<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP21148

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMAPVQLENHQLVPPGGGGGGSGGPASAPAPPPPGAAVAAAAAAAASPGYRLSTLIEFLLHRAYSELMVLTDLLPRKSDVERKIEIVQFASRTRQLFVRLLALVKWANNAGKVEKCAMISSFLDQQAILFVDTADRLASLARDALVHARLPSFAIPYAIDVLTTGSYPRLPTCIRDKIIPPDPITKIEKQATLHQLNQILRHRLVTTDLPPQLANLTVANGRVKFRVEGEFEATLTVMGDDPDVPWRLLKLEILVEDKETGDGRALVHSMQINFIHQLVQSRLFADEKPLQDMYNCLHSFCLSLQLEVLHSQTLMLIRERWGDLVQVERYHAGKCLSLSVWNQQVLGRKTGTASVHKVTIKIDENDVSKPLQIFHDPPLPASDSKLVERAMKIDHLSIEKLLIDSVHARAHQKLQELKAILRGFNANENSSIETALPALVVPILEPCGNSECLHIFVDLHSGMFQLMLYGLDQATLDDMEKSVNDDMKRIIPWIQQLKFWLGQQRCKQSIKHLPTISSETLQLSNYSTHPIGNLSKNKLFIKLTRLPQYYIVVEMLEVPNKPTQLSYKYYFMSVNAADREDSPVMALLLQQFKENIQELVYRTKNGKQPRSSTKRKLSDDLCPVEPKKTKRSGEMCAFNKVLAHFVAMCDTNMPFVGLRLELSNLEIPHQGVQMEGDGFSHAIRLLKIPPCKGVNEETQKALDRSLLDCTFRLQGRNNRTWVAELVFANCPLNGTSTREQGPSRHVYLTYENLLSEPVGGRKVVEMFLNDWNSIARLYECVLEFARSLPDIPTHLNIFSEVRVYNYRKLILCYGTTKGSSISIQWNSIHQKFHISLGTVGPNSGCSNCHNTILHQLQEMFNKTPNVVQLLQVLFDTQAPLNAINKLPTVPMLGLTQRTNTAYQCFSILPQSSTHIRLAFRNMYCIDIYCRSRGVVAIRDGAYSLFDNSKLVEGFYPAPGLKTFLNMFVDSNQDARRRSVNEDDNPPSPIGGDMMDSLISQLQPPPQQQPFPKQPGSSGAYPLTSPPTSYHSTVNQSPSMMHTQSPGTLDPSSPYTMVSPSGRAGNWPGSPQVSGPSPATRMPGMSPANPSLHSPVPDASHSPRAGTSSQTMPTNMPPPRKLPQRSWAASIPTILTHSALNILLLPSPTPGLVPGLAGSYLCSPLERFLGSVIMRRHLQRIIQQETLQLINSNEPGVIMFKTDALKCRVALSPKTNQTLQLKVTPENAGQWKPDELQVLEKFFETRVAGPPFKANTLIAFTKLLGAPTHILRDCVHIMKLELFPDQATQLKWNVQFCLTIPPSAPPIAPPGTPAVVLKSKMLFFLQLTQKTSVPPQEPVSIIVPIIYDMASGTTQQADIPRQQNSSVAAPMMVSNILKRFAEMNPPRQGECTIFAAVRDLMANLTLPPGGRP
Length1410
PositionTail
OrganismPhyseter macrocephalus (Sperm whale) (Physeter catodon)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Laurasiatheria> Artiodactyla> Whippomorpha> Cetacea> Odontoceti> Physeteridae> Physeter.
Aromaticity0.07
Grand average of hydropathy-0.198
Instability index52.13
Isoelectric point8.94
Molecular weight156624.34
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU365082

GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP21148
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      89.51|      18|      30|    1068|    1085|       1
---------------------------------------------------------------------------
 1023- 1044 (26.45/10.88)	SPPTSYHSTVNQSP.SMmhtqSP
 1068- 1085 (36.49/18.09)	SPQVSGPSPATRMP.GM....SP
 1100- 1116 (26.57/10.97)	SPR.AGTSSQT.MPtNM....PP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      93.80|      30|      31|     246|     275|       2
---------------------------------------------------------------------------
  246-  275 (48.45/30.85)	RLLKLEILVEDKETGDGRALVH....SMQINFIH
  276-  309 (45.35/28.41)	QLVQSRLFADEKPLQDMYNCLHsfclSLQLEVLH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     138.62|      40|     161|     705|     797|       3
---------------------------------------------------------------------------
  444-  483 (71.97/28.14)	EPCGNSECLHIFVDLHSGMFQLMLYGLDQA.TLDDMEKSVN
  755-  795 (66.64/50.42)	EPVGGRKVVEMFLNDWNSIARLYECVLEFArSLPDIPTHLN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      87.55|      28|      32|     509|     540|       4
---------------------------------------------------------------------------
  509-  540 (41.94/31.79)	IKHLPT..ISSETLQLSNYSTHpignLSKNKLFI
  542-  571 (45.60/24.58)	LTRLPQyyIVVEMLEVPNKPTQ....LSYKYYFM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     100.78|      31|      31|      66|      96|       5
---------------------------------------------------------------------------
   66-   96 (49.61/34.22)	LMVLTDLLPRKSDVERKIEIVQFASRTRQLF
   99-  129 (51.17/35.53)	LLALVKWANNAGKVEKCAMISSFLDQQAILF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.60|      14|      37|    1203|    1217|       6
---------------------------------------------------------------------------
 1203- 1217 (21.47/18.91)	LKCRVALSP.KTNqTL
 1241- 1255 (22.14/13.35)	FETRVAGPPfKAN.TL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     106.22|      25|     969|      10|      51|       7
---------------------------------------------------------------------------
   10-   34 (51.52/16.59)	QLVPPG.GGGGG..........SGGPASAPAPPPPG
  984- 1014 (34.75/ 6.09)	...PPS.PIGGD.mmdslisqlQPPPQQQPFPKQPG
 1329- 1360 (19.95/ 8.83)	TSVPPQePV..SiivpiiydmaSGTTQQADIPRQ..
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      88.47|      28|     161|    1122|    1167|       9
---------------------------------------------------------------------------
 1122- 1151 (42.65/47.59)	QRSWAASIPTILTHSALNilLLPSPTPGLV
 1169- 1196 (45.82/16.05)	SVIMRRHLQRIIQQETLQ..LINSNEPGVI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     179.39|      45|     508|     149|     194|      11
---------------------------------------------------------------------------
  149-  194 (74.46/56.98)	LPSFAIPYAiDVLTTGSYPRLPT..CIRDKIIPPDPITKIEKQATLHQ
  605-  636 (34.23/18.59)	...............GKQPRSSTkrKLSDDLCPVEP.KKTKRSGEMCA
  661-  703 (70.70/48.92)	LSNLEIPHQ.GVQMEGD..GFSH..AIRLLKIPPCKGVNEETQKALDR
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP21148 with Med14 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) NQDARRRSVNEDDNPPSPIGGDMMDSLISQLQPPPQQQPFPKQPGSSGAYPLTSPPTSYHSTVNQSPSMMHTQSPGTLDPSSPYTMVSPSGRAGNWPGSPQVSGPSPATRMPGMSPANPSLHSPVPDASHSPRAGTSSQTMPTNMPPPRKLPQRSWA
2) VQLENHQLVPPGGGGGGSGGPASAPAPPPP
970
4
1126
33










Molecular Recognition Features






MoRF SequenceStartStop




NANANA