<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP21141

Description mediator of RNA polymerase II transcription subunit 17
SequenceMSGVRAVRISIESACEKQVQEVGLDGTETYLQPLSMSQNLARLAQRIDFSQGSGSEEEEAAGAEGDAQDWAGAGSSADQDDEEGLVKFQPSLWPWDSVRNNLRSALTEMCVLYDVLSIVRDKKFMTLDPVSQDPLPPKQNPQTLQLISKKKSLAGAAQILLKGAERLTKSVTENQENKLQRDFNSELLRLRQHWKLRKVGDKILGDLSYRSAGSLFPHHGTFEVIKNTDIDLDKKIPEDYCPLDVQIPSDLEGSAYIKVSIQKHAPDIGDLGTVNLFRRPLPKSKPEWAMIILYEDKQFIPFHILDYFHLFFFFLGLQLSISLCHSSNDKKSQKSATEKQSPEDHLYVLEHNLHLLIREFHKQTLSSIMMPHPASAPFGHKRMRLSGPQAFDKNEINSLQSSEGLLEKIIKQAKHIFLRSRTAATIDSLASRIEDPQIQAHWSNINDVYESSVKVLITSQGYEQICKSIQLQLNIGVEQIRVVHRDGRVITLSHQEQELQDFLLSQMSQHQVHAVQQLAKVMGWQVLSFSNHVGLGPIESIGNASAITVASPSGDYAISVRNGPESGSKILVQFPRSQCKDLPKSDVLQDSKWNHLRGPFKEVQWNKMEGRNFVYKMELLMSALSPCLL
Length629
PositionHead
OrganismTrichechus manatus latirostris (Florida manatee)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Afrotheria> Sirenia> Trichechidae> Trichechus.
Aromaticity0.07
Grand average of hydropathy-0.391
Instability index57.59
Isoelectric point6.41
Molecular weight70804.82
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP21141
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     780.55|     261|     316|      10|     300|       1
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   10-  300 (379.67/280.90)	SIESACEKQVQEVGLDGTETYLQPL...SMSQNLARLAQRIDFSQGSGSEEEEAAGAEG.DAQDWAGAGSSadQDDEEGLVKFQPSLWpwdsVRNnlRSALTemcvLYDVLSIVRDKKFM....TLDPVSQDPLPPKQNPQTLQLISKKKSL...AGAAQIllKGAERLTKSVT.ENQENKLQrDFnsELLRLRQHwKLRKVGD..KILG..DLSYRSAGSLfphhGTFEVIKNTDIDLDKKIPEDYCpldVQIPSDLEGSAYIKV....SIQKHAP..DIGDLGTVNLFRRPLpkSKPEWAMIilyEDKQFI
  332-  614 (400.88/222.16)	SQKSATEKQSPEDHLYVLEHNLHLLireFHKQTLSSIMMPHPASAPFGHKRMRLSGPQAfDKNEINSLQSS..EGLLEKIIKQAKHIF....LRS..RTAAT....IDSLASRIEDPQIQahwsNINDVYESSVKVLITSQGYEQICKSIQLqlnIGVEQI..RVVHRDGRVITlSHQEQELQ.DF..LLSQMSQH.QVHAVQQlaKVMGwqVLSFSNHVGL....GPIESIGNASAITVASPSGDYA...ISVRNGPESGSKILVqfprSQCKDLPksDVLQDSKWNHLRGPF..KEVQWNKM...EGRNFV
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP21141 with Med17 domain of Kingdom Metazoa
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