<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP21139

Description LOW QUALITY PROTEIN: mediator of RNA polymerase II transcription subunit 12-like protein
SequenceMAAFGLLSYEQRPLKRPRLGPPDVYPQDPKQKEDELTAVNVKQGFNNQPAFTGDEHGSARNIVINPSKIGAYFSSILAEKLKLNTFQDTGKKKPQVNAKDNYWLVTARSQSVIHSWFSDLAGNKPLAILAKKVPILSKKEDVFAYLAKYSVPMVRATWLIKMTCAYYSAISEAKIKKRQATDPNLEWTQISTRYLREQLAKISDFYHMASSTGDGPVPVPPDVEQAVKQWEYNEKLAFHMFQEGMLEKHEYLTWILDVLEKVRPTDDDLLKLLLPLMLQYSDEFVQSAYLSRRLAYFCARRLSLLLSDSPSLLAAHSPHMMIGPNGSSIGVPSPGPAGSGMSPVQLAFSDFLSCAQHGPLVYGLSCMLQTVTLCCPSALVWNYPANDNKSTNPGSPLDLLQVAPSSLPMPGGNTAFNQQVRARIYEVEQQIKQRGRAVEVRWSFDKCRESTAGVTISRVLHTLEVLDRHCFDRTDSSNSMETLYHKIFWPNQNKDNHEVAANDEAVVTLLCEWAVSCKRSGKHRAMAVAKLLEKRQAEVEAERCGESEVLDEKESISSASLAGSSLPVFQNVLLRFLDTQAPSLSDPNSECEKVEFVNLVLLFCEFIRHDVFSHDAYMCTLISRGDLSVSASTRPRSPAGENVDEHYSKDHDVKMEIFSPMPGESCENTNPSLGRRMSVNGEKLMKREKPRELIFPSNYGLLRHLQYATHFPIPLDESSSHECNQRTILLYGVGKERDEARHQLKKITRDILKILNKKSTTETGGGDEGQKARKNKQEAFPTLETVFTKLQLLSYFDQHQVTSQISNNVLEQITSFASGTSYHLPLAHHIQLIFDLMEPALNINGLIDFAIQLLNELSVVEAELLLKSSSLAGSYTTGLCVCIVAVLRRYHSCLILNPDQTAQVFEGLCGVVKHVVNPSECSSPERCILAYLYDLYVSCSHLRSKFGDLFSSACSKVKQTIYNNVMPANSNLRWDPDFMMDFIENPSARSINYSMLGKILSDNAASRYSFVCNTLMNVCMGHQDAGRINDIANFSSELTACCTVLSSEWLGVLKALCCSSNHVWGFNDVLCSVDVSDLSFHDSLATFIAILIARQCFSLEDVVQHVALPSLLAAACGDADAEPGARMTCRILLHLFRAPQACFLPQATGKPFPGIRSSCDRHLLAAAHNSIEVGAVFAVLKAIMMLGDAKIGNNNVSSLKNDDFTMRGLRRDGNADDIWTASQNSKSCGKSISIETANLREYARHVLRTICQQEWVGEHCLKEPERLCTDKELILDPVLSNIQAQKLLQLICYPHGIKECPEGDNLQRQHIKRILQNLEQWTLRQSWLELQLMIKQCLKDPGSGSVAEMNNLLDNIAKATIEVFQQSADLNTSSPSSGMGLFNPNSIGSTDASSTRQNGIKTFLSSSERRGVWLVAPLIARLPTSVQGRVLKAAGEELEKGQHLGSSSKKERDRQKQKSMSLLSQQPFLSLVLTCLKGQDEQREGLLTSLQNQVNQILSNWREERYQDDVKARQMMHEALQLRLNLVRDISNTITNSVPXRKMLSXLSVTWFCFKMKIIVFFHLSELFTTVLDMLGVLINGTLASDLSNASPGGSEENKRAYMNLVKKLKKELGDKRSESIDKVRQLLPLPKQTCDVITCEPMGSLIDTKGNKIAGFDSIDKKQGLQVSAKQKVSPWDLFEGQKNPAPLSWAWFGTVRVDRKVTKYEEQHHLLLYHTHPMPKPRSYYLEPLPLPPEEEEEEPTSPISQEPERKSAELSDQGKTTMDEEKKTKGRKRKTKSSSRVDEYPQSNIYRVPPNYSPISSQMMHHPSSTLWGYNLMGQPQQPGFFLQNQSLTPGTCRDSTSTRSLQDGNNLGCECFQKLDHCSDRCSGCFENGQPGDQAALFAAQARPSPQLPQYPGLQQAQTMPQGYTMYGTQMPLQQMPQQQAGSVVLSPGYNSRTYPAAHSSPALMERLRQMQQPPSGYVQQQAAPYLQSLTSSQRLNHQTLQQSPLVSGGIDAVLTSAHPNLPSVPLPQDPMRPRQPQVRQQQRLLQVRARKLRAARDGPSVTDRANTQQSQEAEDAQMLI
Length2069
PositionKinase
OrganismTrichechus manatus latirostris (Florida manatee)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Afrotheria> Sirenia> Trichechidae> Trichechus.
Aromaticity0.07
Grand average of hydropathy-0.385
Instability index54.67
Isoelectric point7.69
Molecular weight230946.80
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
beta-catenin binding	GO:0008013	IEA:InterPro
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP21139
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     290.09|      88|     152|    1748|    1843|       1
---------------------------------------------------------------------------
 1748- 1843 (144.60/113.11)	QEPERKSAELSDQGKTTMDEEKKTKGRKRKTKSSsrVDEYPQSNIYRVPPNY.SPI....SSQMMHHPSstlwGYnlMGQPQQPGF..FLQNQSLTPGTCRDS
 1898- 1992 (145.49/92.49)	QYPGLQQAQTMPQGYTMYGTQMPLQQMPQQQAGS..VVLSPGYNSRTYPAAHsSPAlmerLRQMQQPPS....GY..VQQQAAPYLqsLTSSQRLNHQTLQQS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     161.06|      66|     157|       2|      88|       2
---------------------------------------------------------------------------
    6-   37 (42.39/28.05)	.............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................LLSYEQRPLKRPRLGPPDVYPQDPKQKEDELT
   45-   88 (28.62/28.28)	FNNQPAFTGDehGSarnIVINPS.....KIGAYfssilAEKLKLNTFQD............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................
  205-  243 (45.11/17.40)	FYHMASSTGD..GP...VPVPPDveqavKQWEY.....NEKLAFHMFQE............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................
 1712- 1743 (44.94/12.39)	.................................................gmlekheyltwildvlekvrptdddllklllplmlqysdefvqsaylsrrlayfcarrlslllsdspsllaahsphmmigpngssigvpspgpagsgmspvqlafsdflscaqhgplvyglscmlqtvtlccpsalvwnypandnkstnpgspldllqvapsslpmpggntafnqqvrariyeveqqikqrgravevrwsfdkcrestagvtisrvlhtlevldrhcfdrtdssnsmetlyhkifwpnqnkdnhevaandeavvtllcewavsckrsgkhramavakllekrqaeveaercgesevldekesissaslagsslpvfqnvllrfldtqapslsdpnsecekvefvnlvllfcefirhdvfshdaymctlisrgdlsvsastrprspagenvdehyskdhdvkmeifspmpgescentnpslgrrmsvngeklmkrekprelifpsnygllrhlqyathfpipldessshecnqrtillygvgkerdearhqlkkitrdilkilnkksttetgggdegqkarknkqeafptletvftklqllsyfdqhqvtsqisnnvleqitsfasgtsyhlplahhiqlifdlmepalninglidfaiqllnelsvveaelllkssslagsyttglcvcivavlrryhsclilnpdqtaqvfeglcgvvkhvvnpsecsspercilaylydlyvscshlrskfgdlfssacskvkqtiynnvmpansnlrwdpdfmmdfienpsarsinysmlgkilsdnaasrysfvcntlmnvcmghqdagrindianfsseltacctvlssewlgvlkalccssnhvwgfndvlcsvdvsdlsfhdslatfiailiarqcfsledvvqhvalpsllaaacgdadaepgarmtcrillhlfrapqacflpqatgkpfpgirsscdrhllaaahnsievgavfavlkaimmlgdakignnnvsslknddftmrglrrdgnaddiwtasqnskscgksisietanlreyarhvlrticqqewvgehclkeperlctdkelildpvlsniqaqkllqlicyphgikecpegdnlqrqhikrilqnleqwtlrqswlelqlmikqclkdpgsgsvaemnnlldniakatievfqqsadlntsspssgmglfnpnsigstdasstrqngiktflssserrgvwlvapliarlptsvqgrvlkaageelekgqhlgssskkerdrqkqksmsllsqqpflslvltclkgqdeqreglltslqnqvnqilsnwreeryqddvkarqmmhealqlrlnlvrdisntitnsvpxrkmlsxlsvtwfcfkmkiivffhlselfttvldmlgvlingtlasdlsnaspggseenkraymnlvkklkkelgdkrsesidkvrqllplpkqtcdvitcepmgslidtkgnkiagfdsidkkqglqvsakqkvspwdlfegqknpaplswawfgtvrvdrkvtkyeeqhhLLLYHTHPMPKPRSYYLEPLPLPPEEEEEEPT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     167.65|      30|     147|     893|     922|       3
---------------------------------------------------------------------------
  893-  922 (54.12/38.07)	CL..ILNPDQTAQVFEGL...CGVVKHV..VNPS....ECS
 1042- 1072 (42.34/27.81)	CT..VLSSEWLG.VLKAL...CCSSNHVwgFNDV....LCS
 1083- 1117 (32.88/19.56)	SLatFIAILIARQCF.SL...EDVVQHV..ALPSllaaACG
 1142- 1170 (38.30/24.28)	CF..L..PQATGKPFPGIrssCD..RHL..LAAA....HNS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     131.34|      38|     202|    1651|    1688|       5
---------------------------------------------------------------------------
 1651- 1688 (67.65/37.58)	GNKIA..GFDSIDKKQGLQVSAKQKVSPWD...LFEGQKNPAP
 1852- 1894 (63.69/34.95)	GNNLGceCFQKLDHCSDRCSGCFENGQPGDqaaLFAAQARPSP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      70.17|      22|     202|    1358|    1399|      12
---------------------------------------------------------------------------
  566-  589 (35.32/10.75)	LPVFQNVLLrfLDTQAPS....LSDPNS
 1361- 1386 (34.85/43.65)	IEVFQQSAD..LNTSSPSsgmgLFNPNS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     137.22|      48|     182|    1257|    1321|      13
---------------------------------------------------------------------------
 1257- 1321 (63.89/87.42)	GEHcLKEPERLCTDKelildpvlsniQAQKLLQLI...........CYpHGIKECPEG..DNLQRQhIKRILQNleqW
 1441- 1501 (73.33/48.52)	GQH.LGSSSKKERDR...........QKQKSMSLLsqqpflslvltCL.KGQDEQREGllTSLQNQ.VNQILSN...W
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      98.23|      31|     152|    1403|    1440|      15
---------------------------------------------------------------------------
  608-  644 (45.38/21.14)	RHDVFshdaYMCTLISRgdLSVSASTRPRSPAGENVD
 1409- 1439 (52.85/28.23)	RRGVW....LVAPLIAR..LPTSVQGRVLKAAGEELE
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP21139 with Med12 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) DQAALFAAQARPSPQLPQYPGLQQAQTMPQGYTMYGTQMPLQQMPQQQAGSVVLSPGYNSRTYPAAHSSPALMERLRQMQQPPSGYVQQQAAPYLQSLTSSQRLNHQTLQQSPLVSGGIDAVLTSAHPNLPSVPLPQDPMRPRQPQVRQQQRLLQVRARKLRAARDGPSVTDRANTQQSQEAEDAQMLI
2) RSYYLEPLPLPPEEEEEEPTSPISQEPERKSAELSDQGKTTMDEEKKTKGRKRKTKSSSRVDEYPQSNIYRVPPNYSPISSQMMH
1881
1724
2069
1808










Molecular Recognition Features






MoRF SequenceStartStop




1) GEEYF
2) HKKEKKKVKD
3) IKAKVTL
4) ITIQI
5) PSLTAVIDKLKHG
6) RLSPDFMIGEEDDDLMD
7) VAKIIISK
660
1280
1184
844
1082
1339
1169
664
1289
1190
848
1094
1355
1176