<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP21139

Description LOW QUALITY PROTEIN: mediator of RNA polymerase II transcription subunit 12-like protein
SequenceMAAFGLLSYEQRPLKRPRLGPPDVYPQDPKQKEDELTAVNVKQGFNNQPAFTGDEHGSARNIVINPSKIGAYFSSILAEKLKLNTFQDTGKKKPQVNAKDNYWLVTARSQSVIHSWFSDLAGNKPLAILAKKVPILSKKEDVFAYLAKYSVPMVRATWLIKMTCAYYSAISEAKIKKRQATDPNLEWTQISTRYLREQLAKISDFYHMASSTGDGPVPVPPDVEQAVKQWEYNEKLAFHMFQEGMLEKHEYLTWILDVLEKVRPTDDDLLKLLLPLMLQYSDEFVQSAYLSRRLAYFCARRLSLLLSDSPSLLAAHSPHMMIGPNGSSIGVPSPGPAGSGMSPVQLAFSDFLSCAQHGPLVYGLSCMLQTVTLCCPSALVWNYPANDNKSTNPGSPLDLLQVAPSSLPMPGGNTAFNQQVRARIYEVEQQIKQRGRAVEVRWSFDKCRESTAGVTISRVLHTLEVLDRHCFDRTDSSNSMETLYHKIFWPNQNKDNHEVAANDEAVVTLLCEWAVSCKRSGKHRAMAVAKLLEKRQAEVEAERCGESEVLDEKESISSASLAGSSLPVFQNVLLRFLDTQAPSLSDPNSECEKVEFVNLVLLFCEFIRHDVFSHDAYMCTLISRGDLSVSASTRPRSPAGENVDEHYSKDHDVKMEIFSPMPGESCENTNPSLGRRMSVNGEKLMKREKPRELIFPSNYGLLRHLQYATHFPIPLDESSSHECNQRTILLYGVGKERDEARHQLKKITRDILKILNKKSTTETGGGDEGQKARKNKQEAFPTLETVFTKLQLLSYFDQHQVTSQISNNVLEQITSFASGTSYHLPLAHHIQLIFDLMEPALNINGLIDFAIQLLNELSVVEAELLLKSSSLAGSYTTGLCVCIVAVLRRYHSCLILNPDQTAQVFEGLCGVVKHVVNPSECSSPERCILAYLYDLYVSCSHLRSKFGDLFSSACSKVKQTIYNNVMPANSNLRWDPDFMMDFIENPSARSINYSMLGKILSDNAASRYSFVCNTLMNVCMGHQDAGRINDIANFSSELTACCTVLSSEWLGVLKALCCSSNHVWGFNDVLCSVDVSDLSFHDSLATFIAILIARQCFSLEDVVQHVALPSLLAAACGDADAEPGARMTCRILLHLFRAPQACFLPQATGKPFPGIRSSCDRHLLAAAHNSIEVGAVFAVLKAIMMLGDAKIGNNNVSSLKNDDFTMRGLRRDGNADDIWTASQNSKSCGKSISIETANLREYARHVLRTICQQEWVGEHCLKEPERLCTDKELILDPVLSNIQAQKLLQLICYPHGIKECPEGDNLQRQHIKRILQNLEQWTLRQSWLELQLMIKQCLKDPGSGSVAEMNNLLDNIAKATIEVFQQSADLNTSSPSSGMGLFNPNSIGSTDASSTRQNGIKTFLSSSERRGVWLVAPLIARLPTSVQGRVLKAAGEELEKGQHLGSSSKKERDRQKQKSMSLLSQQPFLSLVLTCLKGQDEQREGLLTSLQNQVNQILSNWREERYQDDVKARQMMHEALQLRLNLVRDISNTITNSVPXRKMLSXLSVTWFCFKMKIIVFFHLSELFTTVLDMLGVLINGTLASDLSNASPGGSEENKRAYMNLVKKLKKELGDKRSESIDKVRQLLPLPKQTCDVITCEPMGSLIDTKGNKIAGFDSIDKKQGLQVSAKQKVSPWDLFEGQKNPAPLSWAWFGTVRVDRKVTKYEEQHHLLLYHTHPMPKPRSYYLEPLPLPPEEEEEEPTSPISQEPERKSAELSDQGKTTMDEEKKTKGRKRKTKSSSRVDEYPQSNIYRVPPNYSPISSQMMHHPSSTLWGYNLMGQPQQPGFFLQNQSLTPGTCRDSTSTRSLQDGNNLGCECFQKLDHCSDRCSGCFENGQPGDQAALFAAQARPSPQLPQYPGLQQAQTMPQGYTMYGTQMPLQQMPQQQAGSVVLSPGYNSRTYPAAHSSPALMERLRQMQQPPSGYVQQQAAPYLQSLTSSQRLNHQTLQQSPLVSGGIDAVLTSAHPNLPSVPLPQDPMRPRQPQVRQQQRLLQVRARKLRAARDGPSVTDRANTQQSQEAEDAQMLI
Length2069
PositionKinase
OrganismTrichechus manatus latirostris (Florida manatee)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Afrotheria> Sirenia> Trichechidae> Trichechus.
Aromaticity0.07
Grand average of hydropathy-0.385
Instability index54.67
Isoelectric point7.69
Molecular weight230946.80
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
beta-catenin binding	GO:0008013	IEA:InterPro
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP21139
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     290.09|      88|     152|    1748|    1843|       1
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 1748- 1843 (144.60/113.11)	QEPERKSAELSDQGKTTMDEEKKTKGRKRKTKSSsrVDEYPQSNIYRVPPNY.SPI....SSQMMHHPSstlwGYnlMGQPQQPGF..FLQNQSLTPGTCRDS
 1898- 1992 (145.49/92.49)	QYPGLQQAQTMPQGYTMYGTQMPLQQMPQQQAGS..VVLSPGYNSRTYPAAHsSPAlmerLRQMQQPPS....GY..VQQQAAPYLqsLTSSQRLNHQTLQQS
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     161.06|      66|     157|       2|      88|       2
---------------------------------------------------------------------------
    6-   37 (42.39/28.05)	.............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................LLSYEQRPLKRPRLGPPDVYPQDPKQKEDELT
   45-   88 (28.62/28.28)	FNNQPAFTGDehGSarnIVINPS.....KIGAYfssilAEKLKLNTFQD............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................
  205-  243 (45.11/17.40)	FYHMASSTGD..GP...VPVPPDveqavKQWEY.....NEKLAFHMFQE............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................
 1712- 1743 (44.94/12.39)	.................................................gmlekheyltwildvlekvrptdddllklllplmlqysdefvqsaylsrrlayfcarrlslllsdspsllaahsphmmigpngssigvpspgpagsgmspvqlafsdflscaqhgplvyglscmlqtvtlccpsalvwnypandnkstnpgspldllqvapsslpmpggntafnqqvrariyeveqqikqrgravevrwsfdkcrestagvtisrvlhtlevldrhcfdrtdssnsmetlyhkifwpnqnkdnhevaandeavvtllcewavsckrsgkhramavakllekrqaeveaercgesevldekesissaslagsslpvfqnvllrfldtqapslsdpnsecekvefvnlvllfcefirhdvfshdaymctlisrgdlsvsastrprspagenvdehyskdhdvkmeifspmpgescentnpslgrrmsvngeklmkrekprelifpsnygllrhlqyathfpipldessshecnqrtillygvgkerdearhqlkkitrdilkilnkksttetgggdegqkarknkqeafptletvftklqllsyfdqhqvtsqisnnvleqitsfasgtsyhlplahhiqlifdlmepalninglidfaiqllnelsvveaelllkssslagsyttglcvcivavlrryhsclilnpdqtaqvfeglcgvvkhvvnpsecsspercilaylydlyvscshlrskfgdlfssacskvkqtiynnvmpansnlrwdpdfmmdfienpsarsinysmlgkilsdnaasrysfvcntlmnvcmghqdagrindianfsseltacctvlssewlgvlkalccssnhvwgfndvlcsvdvsdlsfhdslatfiailiarqcfsledvvqhvalpsllaaacgdadaepgarmtcrillhlfrapqacflpqatgkpfpgirsscdrhllaaahnsievgavfavlkaimmlgdakignnnvsslknddftmrglrrdgnaddiwtasqnskscgksisietanlreyarhvlrticqqewvgehclkeperlctdkelildpvlsniqaqkllqlicyphgikecpegdnlqrqhikrilqnleqwtlrqswlelqlmikqclkdpgsgsvaemnnlldniakatievfqqsadlntsspssgmglfnpnsigstdasstrqngiktflssserrgvwlvapliarlptsvqgrvlkaageelekgqhlgssskkerdrqkqksmsllsqqpflslvltclkgqdeqreglltslqnqvnqilsnwreeryqddvkarqmmhealqlrlnlvrdisntitnsvpxrkmlsxlsvtwfcfkmkiivffhlselfttvldmlgvlingtlasdlsnaspggseenkraymnlvkklkkelgdkrsesidkvrqllplpkqtcdvitcepmgslidtkgnkiagfdsidkkqglqvsakqkvspwdlfegqknpaplswawfgtvrvdrkvtkyeeqhhLLLYHTHPMPKPRSYYLEPLPLPPEEEEEEPT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     167.65|      30|     147|     893|     922|       3
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  893-  922 (54.12/38.07)	CL..ILNPDQTAQVFEGL...CGVVKHV..VNPS....ECS
 1042- 1072 (42.34/27.81)	CT..VLSSEWLG.VLKAL...CCSSNHVwgFNDV....LCS
 1083- 1117 (32.88/19.56)	SLatFIAILIARQCF.SL...EDVVQHV..ALPSllaaACG
 1142- 1170 (38.30/24.28)	CF..L..PQATGKPFPGIrssCD..RHL..LAAA....HNS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     131.34|      38|     202|    1651|    1688|       5
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 1651- 1688 (67.65/37.58)	GNKIA..GFDSIDKKQGLQVSAKQKVSPWD...LFEGQKNPAP
 1852- 1894 (63.69/34.95)	GNNLGceCFQKLDHCSDRCSGCFENGQPGDqaaLFAAQARPSP
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      70.17|      22|     202|    1358|    1399|      12
---------------------------------------------------------------------------
  566-  589 (35.32/10.75)	LPVFQNVLLrfLDTQAPS....LSDPNS
 1361- 1386 (34.85/43.65)	IEVFQQSAD..LNTSSPSsgmgLFNPNS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     137.22|      48|     182|    1257|    1321|      13
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 1257- 1321 (63.89/87.42)	GEHcLKEPERLCTDKelildpvlsniQAQKLLQLI...........CYpHGIKECPEG..DNLQRQhIKRILQNleqW
 1441- 1501 (73.33/48.52)	GQH.LGSSSKKERDR...........QKQKSMSLLsqqpflslvltCL.KGQDEQREGllTSLQNQ.VNQILSN...W
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      98.23|      31|     152|    1403|    1440|      15
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  608-  644 (45.38/21.14)	RHDVFshdaYMCTLISRgdLSVSASTRPRSPAGENVD
 1409- 1439 (52.85/28.23)	RRGVW....LVAPLIAR..LPTSVQGRVLKAAGEELE
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP21139 with Med12 domain of Kingdom Metazoa
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