<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP21136

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMSSSFVPNGASLEDCHCNLFCLADLTGIKWKRYVWQGPTSAPILFPVTEEDPILSSFSRCLKADVLGVWRRDQRPGRRELWIFWWGEDPNFADLIHHDLSDEEDGLWENGLSYECRTLLFKAVHNLLERCLMNRNFVRIGKWFVKPYEKDEKPINKSEHLSCSFTFFLHGDSNVCTSVEINQHQPVYLLNEEHITLAQQSNSPFQVILSPFGLNGTLTGQAFKMSDSATKKLIGEWKQFYPISSCLKEMSEEKQEDMDWEDDSLAAVEVLVAGVRMIYPACFVLVPQSDIPTPSSVGSSHCSASCLGVHQVPASTRDPAMSSVTLTPPTSPEEVQTVDPQSAQKWVKFSSVSDGFNSDSTSHHGGKIPRKLATHVVDRVWQECNMNRAQNKRKYSASSGGLCEEETADKVASWDFVEVTQRTNCSCSRHKNLKPRNPGQQGQAPSLGQQQQVLPKHKTNEKQEKSEKPQKRPLTPFHHRVSVSDDVSMDTDSASQRLVMSAPDSQVRFSNIRTNDVAKTPQMHGTEIANSPQPPPLSPHPCDVVDEGVTKTPSTPQSQHFYQMPTPDPLVPSKPMEDRIDSLSQSFPAQFQEAVEPTVYVGTAVNLEEDEANIAWKYYKVPKKKDVEFLPPQLPSDKFKDDPVGPFGQESVTSVTELMVQCKKPLKVSDELVQQYQIKNQYLSAIASDAEQESKIDPYAFVEGDEEFLFPDKKDRQNSEREAGKKHKVDDGTSSVTVLSHEEDAMSLFSPSIKQDAPRPTSHARPPSTSLIYDSDLAVSYTDLDNLFNSDEDELTPGSKKSVNGSDDKSSCKESKAGNLDPLSCISTADLHKMYPTPPSLEQHIMGFSPMNMNNKEYGSMDTTPGGTVLEGNNSNIGAQFKIEVDEGFCSPKPSEIKDFSYVYKPENCQVLVGCSMFAPLKSLPSQCLPPIKLPEECIYRQSWTVGKLELLHSGPAMPFIKEGDGSTMDQEYGPAYTPQTHTSFGMPPSSAPPSNGGAGILPSPSTPRFPTPRTPRTPRTPRGAGGPASAQGSVKYENSDLYSPASTPSTCRPLNSVEPATVPSIPEAHSLYVNLILSESVMNLFKDCNFDSCCICVCNMNIKGADVGVYIPDPTQEAQYRCTCGFSAVMNRKFGNNSGLFLEDELDIIGRNTECGKEAEKRFEALRATSAEHVNGGLKESEKLPDELILLLQDQCTNLFSPFGAADQDPFPKIGVISNWVRVEERDCCNDCYLALEHGRQFMDNMSGGKVDEALVKSSCLHPWSKRNVVDVSMQCSQDILRMLLSLQPILQDAIQKKRTVRPWGVQGPLTWQQFHKMAGRGSYGTDESPEPLPIPTFLLGYDYDFLVLSPFALPYWERLMLEPYGSQRDIAYVVLCPENEALLNGAKSFFRDLTAIYESCRLGQHRPISRLLTDGIMRVGSTASKKLSENLVAEWFSQAADGNNEAFSKLKLYAQVCRYDLGPYLASQPLDSSLLSQPNLVVPASQSLITPPQMTNTGNANTPSTTLASAVSNTMTLTSGGAMSSSVATANSTLTTTSASSSSSSSLNSGVSSNKLPSFPPFGSMNSSAAGSMSTQTTTVQNGQLGGQQASALQTAGISGESSLLTTQPHPDVSESTMDRDKVGIPTDGDSHAITYPPAIVVYIIDPFTYENKDESTNSSNVWTLGLLRCFLEMVQTLPPHIKSTVSVQIVPCQYLLQPVKHEDRQIYTQHLKSLAFSAFTQCRRPLPTSTNVKTLTGFGPGLAMETALKSPDRPECIRLYTPPFILAPVKDKQTELGETFGEAGQKYNVLFVGYCLSHDQRWILASCTDLYGELLETCIINIDVPNRARRKKGSARRFGLQKLWEWCLGLIQMSSLPWRVVIGRLGRIGHGELKDWSCLLSRRNLQSLSKRLKDMCRMCGISAADSPSILSACLVAMEPQGSFVIMPDSVSTGSVFGRSTTLNMQTSQLNTPQDTSCTHILVFPTSASVQVASATYTTENLDLAFNPNNDGIGIFDLLDTPDDLDPDIISILPASPTVSPVHSPGSHYPHGGDTGKGQGTDRLLSTESHDEVTNILQQPLALGYFVSTAKAGPLPDWFWSACPQAQYQCPLFLKASLHLHVPSVQSDELLHSKHSHPLDSNQTSDVLRFVLEQYNALSWLTCDPAIQDRRSCLPIHFVVLNQLYNFIMNML
Length2173
PositionMiddle
OrganismTrichechus manatus latirostris (Florida manatee)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Afrotheria> Sirenia> Trichechidae> Trichechus.
Aromaticity0.08
Grand average of hydropathy-0.395
Instability index51.65
Isoelectric point5.41
Molecular weight239559.64
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364134

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP21136
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      91.74|      26|      28|    1098|    1125|       1
---------------------------------------------------------------------------
 1100- 1125 (49.57/33.77)	MNIK.GADVGVYIPDPTQEAQYRCTCG
 1130- 1156 (42.16/20.76)	MNRKfGNNSGLFLEDELDIIGRNTECG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      93.23|      23|      31|     518|     540|       2
---------------------------------------------------------------------------
  523-  554 (38.24/17.48)	HGTEIANSPQPPPLS.......PHPcdvvdegvtK...........TPST
  981- 1009 (32.42/13.41)	H.TSFGMPPSSAPPSnggagilPSP.........S...........TPRF
 1010- 1050 (22.57/ 6.51)	PTPRTPRTPRTPRGA.......GGP..asaqgsvKyensdlyspasTPST
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     118.53|      25|      65|     345|     369|       3
---------------------------------------------------------------------------
  345-  369 (45.62/33.56)	WVKFSSVSDGFNSDSTSHHGGKIPR
  391-  412 (32.20/20.84)	KRKYSASSGGLCEEETA...DKVAS
  413-  435 (40.71/28.90)	W.DFVEVTQRTNCSCSRHKNLK.PR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     151.60|      40|     416|    1474|    1513|       4
---------------------------------------------------------------------------
 1474- 1513 (66.20/41.53)	SLLSQPNLVVPASQSLITP.PQMTNTGNANTPSTTLASAVS
 1525- 1552 (20.27/ 6.53)	............SSSVATAnSTLTTTSASSSSSSSLNSGV.
 1910- 1949 (65.14/40.72)	SILSACLVAMEPQGSFVIM.PDSVSTGSVFGRSTTLNMQTS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     247.56|      75|     416|    1309|    1401|       5
---------------------------------------------------------------------------
  852-  927 (135.68/65.11)	MNNK.EYG...SMDTTPGGTVLEGNNSN..IGAQFKIEVDEGF.CSPKPSEiKDFSY.VYKPENCQVLVGC.SMFAPLKSLPSQC
 1318- 1401 (111.89/76.75)	MAGRgSYGtdeSPEPLPIPTFLLGYDYDflVLSPFALPYWERLmLEPYGSQ.RDIAYvVLCPENEALLNGAkSFFRDLTAIYESC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     213.61|      92|     464|     182|     344|       7
---------------------------------------------------------------------------
    6-   52 (55.86/ 7.43)	VPNGASLEDCHCNLFCLadltGIKWKRYVWQGPT.SAPILFPVT..EE....DP.......................................................................................................................................................................................
  182-  233 (57.78/39.76)	......................................................ilssfsrclkadvlgvwrrdqrpgrrelwifwwgedpnfadlihhdlsdeedglwenglsyecrtllfkavhnllerclmnrnfvrigkwfvkpyekdekpinksehlscsftfflhgdsnvctsveinQHQPVYllnEEHITLAQQ..SNSPFQVILSPFGLNGTLTGQAFKMSDSATKKLI
  290-  339 (41.86/74.89)	IPTPSSVGSSHCSASCL....GVHQVPASTRDPAmSSVTLTPPTspEEvqtvDP.......................................................................................................................................................................................
  448-  498 (58.11/ 7.81)	...........................................................................qsaqkwvkfssvsdgfnsdstshhggkiprklathvvdrvwqecnmnraqnkrkysassgglceeetadkvaswdfvevtqrtncscsrhknlkprnpgqqgqapslgQQQQVL...PKHKTNEKQekSEKPQKRPLTPFHHRVSVSDDVSMDTDSASQRLV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.53|      11|     948|     695|     705|      11
---------------------------------------------------------------------------
  695-  705 (21.10/10.34)	IDPYAFVEGDE
 1646- 1656 (21.43/10.60)	IDPFTYENKDE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     122.07|      31|     718|     943|     976|      12
---------------------------------------------------------------------------
  943-  976 (55.39/49.44)	WTVGKLE.LLHSGPAM.PFIKEgdgSTMDQE..............YGP.AY
 1601- 1640 (28.15/15.13)	...GESS.LLTTQP.H.PDVSE...STMDRDkvgiptdgdshaitYPP.A.
 1664- 1696 (38.54/24.29)	WTLGLLRcFLEMVQTLpPHIK....STVSVQ..............IVPcQY
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP21136 with Med13 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) AGISGESSLLTTQPHPDVSESTMDRDKVGIPTDG
2) CSCSRHKNLKPRNPGQQGQAPSLGQQQQVLPKHKTNEKQEKSEKPQKRPLTPFHHRVSVSDDVSMDTDSASQRLVMSAPDSQVRFSNIRTNDVAKTPQMHGTEIANSPQPPPLSPHPCDVVDEGVTKTPSTPQSQHFYQMPTPDPLVPSKPMEDRIDSLSQSFP
3) GGAMSSSVATANSTLTTTSASSSSSSSLNSGVSSNKLPSFPPFGSMNSSAAGSMSTQTTTVQNGQLGGQQASAL
4) GPAMPFIKEGDGSTMDQEYGPAYTPQTHTSFGMPPSSAPPSNGGAGILPSPSTPRFPTPRTPRTPRTPRGAGGPASAQGSVKYENS
5) LDNLFNSDEDELTPGSKKSVNGSDDKSSCKE
6) SQSLITPPQMTNTGNANTPSTTLASAVSNTM
1597
424
1521
954
783
1486
1630
587
1594
1039
813
1516










Molecular Recognition Features






MoRF SequenceStartStop




NANANA