<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP21135

Description mediator of RNA polymerase II transcription subunit 24 isoform X1
SequenceMKVVNLKQAILQAWKERWSDYQWAINMKKFFPKGATWDILNLAEALLEQAMIGPSPNPLILSYLKYAISSQMVSYSSVLTAISKFDDFSRDLCVQALLDIMDMFCDQLSCHGKAEECIGLCRALLSALHWLLRCTAASAERLREGLEAGIPAAREKQLAMCLQRLEKTLSSTKNRALLHIAKLEEASLHTSQGLGQGGTRANQPTASWTAIEHSLLKLGEILANLSNPQLRSQAEQCGTLIRSIPAMLSVHSEQLHKTGFPTVHAVVLLEGTMNLTGETQPLVEQLMMVKRMQHIPTPLFVLEIWKACFVGLIESPEGTEELKWTAFTFLKIPQVLVKLKKYSHGDKDFTEDVNCAFEFLLKLTPLLDKADQRCNCDCTNFLLQECSKQGLLSEASMTNLVAKRTADREHAPQLKSAENANIQPNPGLILRAEPTVTNILKTMDADHSKSPEGLLGVLGHMLSGKSLDLLLAAAAATGKLKSFARKFIHLNEFTTHGNEESTKPASVRALLFDISFLMLCHVAQTYGSEVILSESSTGAEVPFFETWMQTCMPEEGKILNPDHPCFRPDSTKVESLVALLNNSSEMKLVQMKWHEACLSISAAILEILNAWENGVLAFESIQKITDNIKGKVCSLAVCAVAWLVAHVRMLGLDEREKSLQMIRQLAGPLYSENTLQFYNERVVIMSSILEHMCADVLQQTATQIKFPSTGMDTMPYWNLLPPKRPIKEVLTDIFAKVLEKGWVDSRSIHIFDTLLHMGGVYWFCNNLIKELLKETRKEHTLRAVELLYSIFCLDMQQVTLVLLGHILPGLLTDSSKWHSLMDPPGTALAKLAVWCSLSSYSSHKGQASSRQKKRHREDIEDYISLFPLDDMQPSKLMRLLSSNEEDANILSSPTDRSMSSSLSASQLHKVNMRDPLNRVLASLFLLISSILGSRTAGPHTQFVQWFMEECVDCLEQGSRGSILQFMPFTTVSTSPAAGWPASRSDGLAPPSQVWGFRASPQSREGASFPPRTSNQPAVRWP
Length1021
PositionTail
OrganismTrichechus manatus latirostris (Florida manatee)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Afrotheria> Sirenia> Trichechidae> Trichechus.
Aromaticity0.07
Grand average of hydropathy-0.073
Instability index49.54
Isoelectric point6.58
Molecular weight113765.49
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP21135
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     436.82|     186|     266|      78|     342|       1
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   86-  214 (63.26/130.21)	..........................................................................................................................................................................DDFSRDL.C.......VQALLDIMDMFCDqLSCHG.KAEECIGlcRALLS..ALHWLLrcTAASAERLregleagipaarekqlamclqrlektlsstknrallHIAKL...EEASLHTSQGLgqgGTRAnQPTAS....WTAIEHS
  215-  448 (270.90/237.54)	LLK.LGEILANLSNPQLRSQAEQCGTL...IRSIPAM..LSVHSEQlHKTGFPTVHA....................VVLLEGTmnlTGETQPLVEQLMMVkrmqHIPTPLFVLEIWKACF..........VGLIESPEGTE..ELKWtaftflkipqvlvklkkyshgdKDFTEDVnCafefllkLTPLLDKADQRCN.CDCTNfLLQECSK..QGLLSeaSMTNLV..AKRTADRE....................................HAPQLksaENANIQPNPGL...ILRA.EPTVTnilkTMDADHS
  454-  593 (102.65/44.82)	LLGvLGHMLSGKSLDLLLAAAAATGKLksfARKFIHLneFTTHGNE.ESTKPASVRAllfdisflmlchvaqtygseVILSESS...TGAEVPFFETWMQT....CMPEEGKILNPDHPCFrpdstkveslVALLNNSSEMKlvQMKW.........................................................................................................................................................................
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.84|      15|      74|     789|     803|       3
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  789-  803 (27.55/17.91)	SIFCL.DMQQVTLVLL
  864-  879 (24.29/14.91)	SLFPLdDMQPSKLMRL
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     156.60|      47|     181|     723|     776|       4
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  723-  776 (73.21/69.05)	KRPIKEVLTDIFakVLEKGWVDSRSIHIfdtllHMGGVYWFCNNLIKELLKETR
  913-  959 (83.40/58.77)	RDPLNRVLASLF..LLISSILGSRTAGP.....HTQFVQWFMEECVDCLEQGSR
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP21135 with Med24 domain of Kingdom Metazoa
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