<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP21132

Description mediator of RNA polymerase II transcription subunit 12 isoform X2
SequenceMAAFGILSYEHRPLKRPRLGPPDVYPQDPKQKEDELTALNVKQGFNNQPAVSGDEHGSAKNVNFNPAKISSNFSSIIAEKLRCNTLPDTGRRKPQVNQKDNFWLVTARSQSAINTWFTDLAGTKPLTQLAKKVPIFSKKEEVFGYLAKYTVPVMRAAWLIKMTCAYYAAITETKVKKRHVIDPFMEWTQIITKYLWEQLQKMAEYYRPGPAGSGSCASTIGPLPHDVEVAIRQWDYNEKLAMFMFQDGMLDRHEFLTWVLECFEKIRPGEDELLKLLLPLLLRYSGEFVQSAYLSRRLAYFCTRRLALQLDGVSSHSSHVMSAQSTSTLPTTPAPQPPTTSTPSTPFSDLLMCPQHRPLVFGLSCILQTILLCCPSALVWHYSLTDSRIKTGSPLDHLPIAPSNLPMPEGNSAFTQQVRAKLREIEQQIKERGQAVEVRWSFDKCQEATAGFTIGRVLHTLEVLDSHSFERSDFSNSLDSLCNRIFGLGPSKDGHEISSDDDAVVSLLCEWAVSCKRSGRHRAMVVAKLLEKRQAEIEAERCGESEAADEKGSIASGSLSAPSAPIFQDVLLQFLDTQAPMLTDPRSESERVEFFNLVLLFCELIRHDVFSHNMYTCTLISRGDLAFGAPGPRPPSPFDDPADDSERKEAEGSSSSKLEDPGLSESMDIDPSSSVLFEDMEKPDFSLFSPTMPCEGKGSPSPEKPDVEKEVKSQPKEKIEGTLGVLYDQPRHVQYATHFPIPQEESCSHECNQRLVVLFGVGKQRDDARHAIKKITKDILKVLNRKGTAETDQLAPIVPLNPGDLTFLGGEDGQKRRRNRPEAFPTAEDIFAKFQHLSHYDQHQVTAQVSRNVLEQITSFALGMSYHLPLVQHVQFIFDLMEYSLSISGLIDFAIQLLNELSVVEAELLLKSSDLVGSYTTSLCLCIVAVLRHYHACLILNQDQMAQVFEGLCGVVKHGMNRSDGSSAERCILAYLYDLYTSCSHLKSKFGELFSDFCSKVKNTIYCNVEPSESNMRWAPEFMIDTLENPAAHTFTYTGLGKSLSENPANRYSFVCNALMHVCVGHHDPDRVNDIAILCAELTGYCKSLSAEWLGVLKALCCSSNNGTCGFNDLLCNVDVSDLSFHDSLATFVAILIARQCLLLEDLIRCAAIPSLLNAACSEQDSEPGARLTCRILLHLFKTPQLNPCQSDGNKPTVGIRSSCDRHLLAASQNRIVDGAVFAVLKAVFVLGDAELKGSGFTVTGGTEELPEEEGGGGSGGRRQGGRNISVETASLDVYAKYVLRSICQQEWVGERCLKSLCEDSNDLQDPVLSSAQAQRLMQLICYPHRLLDNEDGENPQRQRIKRILQNLDQWTMRQSSLELQLMIKQTPNNEMNALLENIAKATIEVFQQSAETGSSSGNTASNMPSSSKTKPVLSSLERSGVWLVAPLIAKLPTSVQGHVLKAAGEELEKGQHLGSSSRKERDRQKQKSMSLLSQQPFLSLVLTCLKGQDEQREGLLTSLYSQVHQIVNNWRDDQYLDDCKPKQLMHEALKLRLNLVGGMFDTVQRSTQQTTEWAVLLLEIIISGTVDMQSNNELFTTVLDMLSVLINGTLAADMSSISQGSMEENKRAYMNLVKKLRKELGERQSDSLEKVRQLLPLPKQTRDVITCEPQGSLIDTKGNKIAGFDSIFKKEGLQVSTKQKISPWDLFEGLKPSAPLSWGWFGTVRVDRRVARGEEQQRLLLYHTHLRPRPRAYYLEPLPLPPEDEEPPAPTLLEPEKKAPDPPKTDKPGAAPPSTEERKKKSTKGKKRSQPATKTEDYGMGPGRSGPYGVAVPPDLLHHPASGSISHLSYRQGSIGLYTQNQPLPAGGPRVDPYRPVRLPMQKLPTRPTYPGVLPATMTSVMGLDPSSYKTSVYRQQQPAVPQGQRLRQQLQAKIQSQGMLGQSSVHQMTPSSSYGLQTSQGYTPYVSHVGLQQHTGPAGTMVPPSYSSQPYQSTHPSTNPTLVDPTRHLQQRPSGYVHQQAPTYGHGLTTQRFSHQTLQQTPMIGTMTPLSAQGVQAGVRSTSILPEQQQQQQQQQQQQQQQQYHIRQQQQQQILRQQQQQQQQQQQQQQQQQQQQQQQQQQQQQHQQQQQTAPPQPQPQSQPQFQRQGLQQTQQQQQTAALVRQLQQQLSNTQPQPNTNIFGRF
Length2171
PositionKinase
OrganismTrichechus manatus latirostris (Florida manatee)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Afrotheria> Sirenia> Trichechidae> Trichechus.
Aromaticity0.07
Grand average of hydropathy-0.492
Instability index56.56
Isoelectric point6.76
Molecular weight242289.03
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
beta-catenin binding	GO:0008013	IEA:InterPro
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats
>MDP21132
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     262.09|      30|      30|    2050|    2079|       1
---------------------------------------------------------------------------
 1923- 1960 (30.11/10.92)	QGMLGQSSVHQMTPSS..............SyglQTSQGYtpyvsHVGLQQH
 1966- 2008 (33.22/12.94)	TMVPPSYSSQPYQSTHpstnptlvdptrhlQ...QRPSGY......VHQQAP
 2049- 2077 (54.71/26.87)	.SILPEQQQQQQQQQQ..............Q...QQQQQY.....HIRQQQQ
 2078- 2100 (48.85/23.07)	QQIL...RQQQQQQQQ..............Q...QQQQQ.........QQQQ
 2101- 2124 (47.10/21.93)	QQ.....QQQQQQQQQ..............H...QQQQQ......TAPPQPQ
 2125- 2154 (48.11/22.59)	PQSQPQFQRQGLQQTQ..............Q...QQQTAA.....LVRQLQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.38|      13|      16|     864|     879|       2
---------------------------------------------------------------------------
  864-  876 (24.86/18.38)	MSYHLPLVQHVQF
  881-  893 (22.52/ 7.21)	MEYSLSISGLIDF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.49|      16|      16|     645|     660|       3
---------------------------------------------------------------------------
  645-  660 (26.33/14.97)	SERKEAEGSSSSKLED
  664-  679 (28.16/16.55)	SESMDIDPSSSVLFED
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     525.87|     168|     231|     219|     408|       4
---------------------------------------------------------------------------
  219-  408 (273.95/236.93)	TIGPLPHDVEV....AIRQWDYNEKLamfmfqDGMLDRHEFLTWVLECFEkIRPGEDELLKLLLPLLL..RYSGE...FVQSAYLSRRLAYFCTRRLalqldGVSSHSSHVMSAQSTS.TLPTTPAPQPPTTSTPSTPfSDLLMCPQ...HRPLVFGLscilqtILLCCP...SALVWH..YSLT.DSR..IKTGSPldhLPIAPSNLPMP
  453-  641 (251.92/168.30)	TIGRVLHTLEVldshSFERSDFSNSL......DSLCNRIFGLGPSKDGHE.ISSDDDAVVSLLCEWAVscKRSGRhraMVVAKLLEKRQAEIEAERC.....GESEAADEKGSIASGSlSAPSAPIFQDVLLQFLDTQ.APMLTDPRsesERVEFFNL......VLLFCElirHDVFSHnmYTCTlISRgdLAFGAP...GPRPPSPFDDP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.14|      13|      16|    1028|    1040|       5
---------------------------------------------------------------------------
 1028- 1040 (25.11/20.18)	ENPAA.HTFTYTGL
 1046- 1059 (21.03/15.33)	ENPANrYSFVCNAL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      92.09|      21|      21|    1735|    1755|       6
---------------------------------------------------------------------------
 1735- 1755 (41.24/20.39)	PRAYYLEP..LPLPP........EDEEPPAP
 1854- 1876 (29.02/11.75)	PRVDPYRPvrLPMQK........LPTRPTYP
 1880- 1907 (21.83/ 6.65)	P.ATMTSV..MGLDPssyktsvyRQQQPAVP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     651.78|     185|     206|    1203|    1408|       7
---------------------------------------------------------------------------
 1065- 1177 (119.25/70.30)	...........................................................GHHDPDRvnDIAILCAELTGYCKSL.....SAEWLG..VLKALCCSSNN.............................................GTCGFNDLLCNVDVSDLSfHDSLATFVAILIA.......RQCL....LLEDLIRcAAIPSLLNAAcsEQDSEPGArlTCRIL
 1203- 1408 (276.33/231.30)	SCDRHLLaASQNRivdGAVFAVLKAVFVLgDAELKGSGFTVTGgtEELpeEEGGG.GSGGRRQGGR..NISVETASLDVYAKYVLRSICQQEWVGERCLKSLCEDSNDL.....QDPVLSSaqaqrlmqliCYPHRLLD.......NEDGenPQRQRIKRILQNLDQWTMR.QSSLELQLMIKQT....PNNEMNA....LLENIAK.ATIEVFQQSA..ETGSSSGN..TASNM
 1412- 1615 (256.21/166.63)	SKTKPVL.SSLER...SGVWLVAPLIAKL.PTSVQGHVLKAAG..EEL..EKGQHlGSSSRKERDRqkQKSMSLLSQQPFLSLVLTCLKGQDEQREGLLTSLYSQVHQIvnnwrDDQYLDD..........CKPKQLMHealklrlNLVG..GMFDTVQRSTQQTTEWAV.....LLLEIIISGTvdmqSNNELFTtvldMLSVLIN.GTLAADMSSI..SQGSMEEN..KRAYM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.86|      15|      19|    1661|    1679|       8
---------------------------------------------------------------------------
 1661- 1679 (14.83/24.89)	TKgNKIAGFDsIFkkEGLQ
 1682- 1696 (30.03/19.83)	TK.QKISPWD.LF..EGLK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      76.64|      17|      19|    1780|    1796|       9
---------------------------------------------------------------------------
 1759- 1773 (22.12/ 9.04)	..EPEKKAPDPPKTDKP
 1780- 1796 (29.18/14.38)	TEERKKKSTKGKKRSQP
 1800- 1812 (25.33/11.47)	TED....YGMGPGRSGP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     151.38|      47|     149|     792|     842|      12
---------------------------------------------------------------------------
  755-  801 (74.98/48.81)	LVVLFGV.GKQRDDARHAIKKITKDILKVLNRKGTAETDQLAPIVPLN
  805-  852 (76.40/45.91)	LTFLGGEdGQKRRRNRPEAFPTAEDIFAKFQHLSHYDQHQVTAQVSRN
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP21132 with Med12 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) AYYLEPLPLPPEDEEPPAPTLLEPEKKAPDPPKTDKPGAAPPSTEERKKKSTKGKKRSQPATKTEDYGMGPGRSGPYGVAVPPDLLHHPASGSISHLSYRQGSIGLYTQNQPLPAGGPRVDPYRPVRLPMQKLPTRPTYPGVLPATMTSVM
2) FSPTMPCEGKGSPSPEKPDVEKEVKSQPKEKIEGTLGVLY
3) GAPGPRPPSPFDDPADDSERKEAEGSSSSKLEDPGLSESMDIDPSSSV
4) KRPRLGPPDVYPQDPKQKEDELTALNVKQGFNNQPAVSGDEHGSAKN
5) LDPSSYKTSVYRQQQPAVPQGQRLRQQLQAKIQSQGMLGQSSVHQMTPSSSYGLQTSQ
6) TPYVSHVGLQQHTGPAGTMVPPSYSSQPYQSTHPSTNPTLVDPTRHLQQRPSGYVHQQAPTYGHGLTTQRFSHQTLQQTPMIGTMTPLSAQGVQAGVRSTSILPEQQQQQQQQQQQQQQQ
1737
688
628
15
1889
1949
1887
727
675
61
1946
2068










Molecular Recognition Features






MoRF SequenceStartStop




1) MAAFG
2) QQILRQQ
1
2078
5
2084