Description | Mediator of RNA polymerase II transcription subunit 1 |
Sequence | MSSGGHQHLVSCLETLQKALKVTSLPAMTDRLESIARQNGLGSHLSASGTECYITSDMFYVEVQLDPAGQLCDVKVAHHGENPVSCPELVQQLREKNFDEFSKHLKGLVNLYNLPGDNKLKTKMYLALQSLEQDLSKMAIMYWKATNASPLDKILHGSVGYLTPRSGGHLMNLKYYASPSDLLDDKTTSPIILHENTVPRCLGMNASVTIEGTSSMYKLPIAPLIMGSHPVDNKWTPSFSSITSANSVDLPACFFLKFPQPIPVSRAFVQKLQNCTGIPLFEAQPTYVPLYELITQFELSKDPDPIPLNHNMRFYAALPGQQHCYFLNKDAPLPDGRSLQGTLVSKITFQHPGRVPLILNLIRHQVAYNTLIGSCVKRTILKEDSPGLLQFEVCPLSESRFSVSFQHPVNDSLVCVVMDVQDSTHVSCKLYKGLSDALICTDDFIAKVVQRCMSIPVTMRAIRRKAETIQADTPALSLIAETVEDMVKKNLPPASSPGYGMTTGNNPMSGTTTPTNTFPGGPITTLFNMSMSIKDRHESVGHGEDFSKVSQNPILTSLLQITGNGGSTIGSSPTPPHHTPPPVSSMAGNTKNHPMLMNLLKDNPAQDFSTLYGSSPLERQNSSSGSPRMEMCSGSNKTKKKKSSRLPPDKPKHQTEDDFQRELFSMDVDSQNPIFDVNMTADTLDTPHITPAPSQCSTPPTTYPQPIPHPQPSIQRMVRLSSSDSIGPDVTDILSDIAEEASKLPSTSDDCPPIGTPVRDSSSSGHSQSALFDPDVFQTNNNENPYTDPADLIADAAGSPSSDSPTNHFFPDGVDFNPDLLNSQSQSGFGEEYFDESSQSGDNDDFKGFASQALNTLGVPMLGGDNGDTKFKGNSQADTVDFSIIAVAGKALGPADIMEHHSGSQSPLLTTGDLGKEKSQKRVKEGNGTSNSSLSGPGLDSKPGKRSRTPSNDGKSKDKPPKRKKADTEGKSPSHSSSNRPFTPPTSTGGSKSPGSSGRSQTPPGVATPPIPKITIQIPKGTVMVGKSSSHNQYTSSGSVSSSGSKSHHSHSSSSSSSASASGKMKSSKSEGSSSSKLSSSMYSSQGSSGSSQSKNSSQSGGKPGSSPITKHGLSSGSSSTKMKPQGKPSTLMNPSLSKPNISPSHSRPPGASDKLSSPMKPIPGTPPSSKAKSPISSGSGGSHISGTSSSSGMKSSSGLGSSGSLSQKTPPSSNSCTASSSSFSSSGSSMSSSQNQHGSSKGKSPSRNKKPSLTAVIDKLKHGVVTSGPGGEDQMDGQMGVSTNSSHSMSSKHNMSGGEFQGKREKSDKDKSKVSTSGGSVDSSKKTSESKNVGSTGVAKIIISKHDGGSPSIKAKVTLQKPGESSGEGLRPQMASSKNYGSPLISGSTPKHERGSPSHSKSPAYTPQNLDSESESGSSIAEKSYQNSPSSDDGIRPLPEYSTEKHRKHKKEKKKVKDKDRDRDRDKDRDKKKSHSIKPENWSKSPISSDQSLSMTSNTILSADRPSRLSPDFMIGEEDDDLMDVALIGN |
Length | 1531 |
Position | Middle |
Organism | Trichechus manatus latirostris (Florida manatee) |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Afrotheria> Sirenia> Trichechidae> Trichechus. |
Aromaticity | 0.04 |
Grand average of hydropathy | -0.674 |
Instability index | 53.36 |
Isoelectric point | 8.78 |
Molecular weight | 162704.56 |
Publications |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364059 |
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro |
Binary Interactions |
Repeats | >MDP21130 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 6| 339.90| 48| 48| 1028| 1075| 1 --------------------------------------------------------------------------- 928- 973 (44.19/ 8.79) G.......TSNSSLSGPGLDSKPGKRSRTP.....SNDGKSkdkpP.......KRKKADTEGKSP 976- 1022 (39.99/ 7.13) SSS.NRPFTPPT..STGGSKS....PGSSG.....RSQTPP....GvatppipKITIQIPKGT.. 1028- 1075 (84.09/24.60) SSS.HNQYTSSGSVSSSGSKSHHSHSSSSS.....SSASAS....G.......KMKSSKSEGSSS 1079- 1120 (62.17/15.91) SSS...MYSSQGSSGSSQSK....NSSQSG.....GKPGSS....P.......ITKHGLSSGSSS 1129- 1182 (48.85/10.64) PSTlMNPSLSKPNISPSHSRPPGASDKLSSpmkpiPGTPPS....S.......KAKSPISSGSGG 1189- 1231 (60.61/15.29) SSS.SGMKSSSG.LGSSGSLSQKTPPSSNS.....CTASSS...............SFSSSGSSM --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 4| 242.00| 49| 50| 1259| 1307| 2 --------------------------------------------------------------------------- 1268- 1317 (80.02/33.80) SGPGGEDQMDGQMGVSTNSSHSMS...........SK..HNMSGGEFQGKREKsD.KDK...SKV....ST 1318- 1366 (47.28/16.68) SG........GSVDSSKKTSESKNvgstgvakiiiSK..HD..GGSPSIKAKV.T.LQK...PG.....ES 1367- 1407 (58.27/22.43) SGEG....LRPQMASSKNYGSPL..................ISGSTPKHERGS.PsHSK...SPA....YT 1428- 1484 (56.43/21.46) NSPSSDDGIRPLPEYSTEK.HRKH...........KKekKKVKDKDRDRDRDK.D.RDKkksHSIkpenWS --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 3| 216.64| 50| 50| 101| 150| 3 --------------------------------------------------------------------------- 101- 150 (83.01/48.01) FSKHLKGLVNLYNLP......GDNKLKTKMYLALQSLEQ....DLSKMAIMYWKATNASP 151- 199 (73.52/41.61) LDKILHGSVG.YLTP....rsGGHLMNLKYYASPSDLLD....DKTTSPIILHE..NTVP 210- 263 (60.11/32.56) ....IEGTSSMYKLPiaplimGSHPVDNKWTPSFSSITSansvDLP..ACFFLKFPQPIP --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 3| 190.17| 49| 50| 275| 324| 4 --------------------------------------------------------------------------- 275- 324 (87.72/50.40) CTGIPLFEAqPTYVPLY.ELITQFELSKDPDPIPLNHNM...............RF...YAALPGQQHC 334- 375 (42.43/18.75) ..........PDGRSLQgTLVSKITF.QHPGRVPLILNL..............iRHqvaYNTLIGS..C 385- 440 (60.02/29.71) SPGLLQFEV....CPLS.E..SRFSVSFQH...PVNDSLvcvvmdvqdsthvscKL...YKGLSDALIC --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 4| 111.19| 18| 20| 492| 509| 5 --------------------------------------------------------------------------- 492- 509 (38.50/18.93) PPASSPGYGMTTGNNPMS 514- 530 (26.80/10.35) PTNTFPGGPITTLFN.MS 581- 595 (20.91/ 6.03) PPVSS..MAGNTKNHPM. 622- 639 (24.98/ 9.02) SSSGSPRMEMCSGSNKTK --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 5| 348.61| 63| 65| 752| 816| 6 --------------------------------------------------------------------------- 541- 580 (39.45/13.21) .............GHGED..FS.KV.....SQNPI..LTSLLQ.I........TGNG..GSTigsSPTPpHH....TP..... 660- 709 (64.83/26.65) Q......RE..........LFSMDV....DSQNPIFD.VNMTADTldtphitpAPSQ..CST...PPTT.......YPQPIPH 712- 750 (58.13/23.10) PSIQRMVRLSSSDSIG.................P..DVTDILSDI........AEEA..SK...............LPSTSDD 752- 816 (107.87/56.31) PPIGTPVRDSSSSGHSQSaLFDPDVfQTNNNENPYTDPADLIADA........AGSP..SSD...SPTN.HF....FPDGVDF 818- 882 (78.33/33.80) PDL...LNSQSQSGFGEE.YFDESS.QSGDNDD.FKGFASQALNT........LGVPmlGGD...NGDT.KFkgnsQADTVDF --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) FGEEYF 2) IKAKVTLQ 3) KITIQIP 4) KPSLTAVIDKLKHG 5) LPEYSTEKHRKHKKEKKKVKDK 6) RLSPDFMIGEEDDDLMDV 7) VAKIIISKH | 829 1354 1013 1251 1439 1509 1339 | 834 1361 1019 1264 1460 1526 1347 |
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