<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP21126

Description Mediator of RNA polymerase II transcription subunit 1
SequenceMYLALQSLEQDLSKMAIMYWKATNASPLDKILHGSVGYLTPRSGGHLMNLKYYASPSDLLDDKTTSPIILHENTVPRCLGMNASVTIEGTSSMYKLPIAPLIMGSHPVDNKWTPSFSSITSANSVDLPACFFLKFPQPIPVSRAFVQKLQNCTGIPLFEAQPTYVPLYELITQFELSKDPDPIPLNHNMRFYAALPGQQHCYFLNKDAPLPDGRSLQGTLVSKITFQHPGRVPLILNLIRHQVAYNTLIGSCVKRTILKEDSPGLLQFEVCPLSESRFSVSFQHPVNDSLVCVVMDVQDSTHVSCKLYKGLSDALICTDDFIAKVVQRCMSIPVTMRAIRRKAETIQADTPALSLIAETVEDMVKKNLPPASSPGYGMTTGNNPMSGTTTPTNTFPGGPITTLFNMSMSIKDRHESVGHGEDFSKVSQNPILTSLLQITGNGGSTIGSSPTPPHHTPPPVSSMAGNTKNHPMLMNLLKDNPAQDFSTLYGSSPLERQNSSSGSPRMEMCSGSNKTKKKKSSRLPPDKPKHQTEDDFQRELFSMDVDSQNPIFDVNMTADTLDTPHITPAPSQCSTPPTTYPQPIPHPQPSIQRMVRLSSSDSIGPDVTDILSDIAEEASKLPSTSDDCPPIGTPVRDSSSSGHSQSALFDPDVFQTNNNENPYTDPADLIADAAGSPSSDSPTNHFFPDGVDFNPDLLNSQSQSGFGEEYFDESSQSGDNDDFKGFASQALNTLGVPMLGGDNGDTKFKGNSQADTVDFSIIAVAGKALGPADIMEHHSGSQSPLLTTGDLGKEKSQKRVKEGNGTSNSSLSGPGLDSKPGKRSRTPSNDGKSKDKPPKRKKADTEGKSPSHSSSNRPFTPPTSTGGSKSPGSSGRSQTPPGVATPPIPKITIQIPKGTVMVGKSSSHNQYTSSGSVSSSGSKSHHSHSSSSSSSASASGKMKSSKSEGSSSSKLSSSMYSSQGSSGSSQSKNSSQSGGKPGSSPITKHGLSSGSSSTKMKPQGKPSTLMNPSLSKPNISPSHSRPPGASDKLSSPMKPIPGTPPSSKAKSPISSGSGGSHISGTSSSSGMKSSSGLGSSGSLSQKTPPSSNSCTASSSSFSSSGSSMSSSQNQHGSSKGKSPSRNKKPSLTAVIDKLKHGVVTSGPGGEDQMDGQMGVSTNSSHSMSSKHNMSGGEFQGKREKSDKDKSKVSTSGGSVDSSKKTSESKNVGSTGVAKIIISKHDGGSPSIKAKVTLQKPGESSGEGLRPQMASSKNYGSPLISGSTPKHERGSPSHSKSPAYTPQNLDSESESGSSIAEKSYQNSPSSDDGIRPLPEYSTEKHRKHKKEKKKVKDKDRDRDRDKDRDKKKSHSIKPENWSKSPISSDQSLSMTSNTILSADRPSRLSPDFMIGEEDDDLMDVALIGN
Length1408
PositionMiddle
OrganismTrichechus manatus latirostris (Florida manatee)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Afrotheria> Sirenia> Trichechidae> Trichechus.
Aromaticity0.04
Grand average of hydropathy-0.701
Instability index54.04
Isoelectric point8.94
Molecular weight149185.31
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP21126
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             8|     349.18|      40|      41|     913|     952|       1
---------------------------------------------------------------------------
  832-  877 (45.00/10.76)	K.......SKDKPPkrkkadTEG.KSP.SHSSSNR.....PFTPptS.TG..GSKSPGSSGRS
  913-  951 (62.33/18.52)	........SSGSVS......SSGSKSHHSHSSSSS.....SSAS..A.SG..KMKSSKSEGSS
  976- 1006 (43.39/10.03)	Q.......SGGKPG......SSPITKH......GL.....SSGS..S.ST..KMK...PQGKP
 1007- 1058 (40.92/ 8.93)	StlmnpslSKPNIS......PSHSRPPGASDKLSSpmkpiPGTP..P.SS..KAKSPISSGSG
 1059- 1092 (36.15/ 6.79)	G.....shISGTSS......SSGMKS....SSGLG.....SSGS..L.SQ..K....TPPSSN
 1093- 1131 (44.69/10.62)	S....ctaSSSSFS......SSGS....SMSSSQN.....QHGS..S.KG..KSPSRNKKPSL
 1189- 1228 (38.10/ 7.66)	K.......SK..VS......TSGGSVDSSKKTSES.....KNVG..S.TGvaKIIISKHDGGS
 1257- 1296 (38.61/ 7.89)	........NYGSPL......ISGSTPKHERGSPSH.....SKSP..AyTP..QNLDSESESGS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     219.11|      49|      50|     152|     201|       2
---------------------------------------------------------------------------
  100-  150 (41.27/18.07)	....PLIMgSHPVdnkWTPSFSSITsansvdlpaCFFL.KFPQPIPVSRA...F...VQKL...Q..
  152-  201 (89.46/52.84)	CTGIPLFE.AQPT...YVPLYELIT.........QFELSKDPDPIPLNHNM.RF...YAALPGQQhC
  210-  252 (49.26/23.33)	.....LPD.GRSL...QGTLVSKIT..........F...QHPGRVPLILNLiRHqvaYNTLIGS..C
  262-  290 (39.11/16.72)	SPGLLQFE.V.......CPLSE..S.........RFSVSFQH...PVNDSL................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     364.01|      64|      64|     377|     440|       3
---------------------------------------------------------------------------
  377-  427 (81.85/36.68)	...............GMT..T..G...NN..PM.....SGTTTPTN.TFPGGPIT....TLFNM.SMSI...KDRHESVGHGED.FSK......V.S
  428-  478 (72.92/31.57)	QNPILTSLLQITGngGST..I..G...SS..P.........TPPHH.TPP..PVS....S...M.AGNT...KN......HPML.MNL......L.K
  479-  547 (51.09/19.10)	DNP........AQ..DFS..TlyG...SS..PL.erqnSSSGSPRM.EMCSGSNK....TKKKK.SSRLppdKPKHQT...EDD.FQRelfsmdVdS
  548-  609 (52.15/19.70)	QNPIFD..VNMTA...........dtlDT..PHitpapSQCSTPPT.TYP.QPIPhpqpSIQRMvRLSS...SD...SI..GPD.VTD.........
  610-  660 (43.43/14.72)	...ILSDIAEEAS..KLP..S..T...SDdcPP.....IGTPVRDS.SSSGHSQS....ALFDP.DVFQ...TNNNE....................
  661-  715 (62.57/25.66)	.NPYTDPADLI.......adA..A...GS..PS.....S..DSPTNhFFPDG.......VDFNP.DL.L...NSQSQS.GFGEEyFDE......S.S
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      40.90|      12|      15|    1322|    1333|       5
---------------------------------------------------------------------------
 1322- 1333 (20.40/11.20)	EKHRKHKKEKKK
 1340- 1351 (20.49/11.28)	DRDRDKDRDKKK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      66.64|      20|      23|     766|     785|       7
---------------------------------------------------------------------------
  766-  785 (36.25/18.36)	GKALGPADIMEHHSGSQSPL
  792-  811 (30.39/14.03)	GKEKSQKRVKEGNGTSNSSL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP21126 with Med1 domain of Kingdom Metazoa
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