<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP21124

Description mediator of RNA polymerase II transcription subunit 23 isoform X4
SequenceMVQMETQLQSIFEEVVKTEIIEEAFPGMFMDTPEDEKTKLISCLGAFRQFWAGLSQESHEQCIQWIVKFVHGQHSPKRISFLYDCLAMAVETGLLPPRMVCESLINSDTLEWERTQLWALTFKLVRKIIGGVDYKGVRDLLKVILEKILTIPNTVSSAVVQQLLVAREVIAYILERNACLLPAYFAVTEIRKLYPEGKLPHWLLGNLVSDFVDTFRPTARINSICGRCSLLPVVNNSGAICNSWKLDPATLRFPLKGLLPYDKHKQRCPVLEDQLVDLVVYAMERSETEEKFDDGGTSQLLWQHLSSQLIFFVLFQFASFPHMVLSLHQKLAGRGLIKGRDHLMWVLLQFISGSIQKNALADFLPVMKLFDLLYPEKECIPVPDINKPQSTHAFAMTCIWIHLNRKAQNDNSKLQIPIPHSLKLHHEFLQQSLRNKSLQMNDYKIALLCNAYSTNSECFTLPMGALVETIYGNGIMRIPLPGTSCVASGSITPLPMNLLDSLTVHAKMSLIHSIATRVIKLAHAKSSVALAPALVETYSRLLVYMEIESLGIKGFISQLLPTVFKSHAWGILHTLLEMFSYRMHHIQPHYRVQLLSHLHTLAAVAQTNQNQLHLCVESTALRLITALGSSEVQPQFTRFLSDPKTVLSAESEELNRALILTLARATHVTDFFTGSDSIQGTWCKDILQTIMSFTPHNWASHTLSCFPGPLQAFFKQNNVPQESRFNLKKNVEEEYRKWKSMSNENDIITHFSKQGSSPLFLCLLWKMLLETDHINQIGYRVLERIGARALVAHVRTFADFLVYEFSTSAGGQQLNKCIEILNDMVWKYNIVTLDRLILCLAMRSHEGNEAQVCYFIIQLLLLKPNDFRNRVSDFVKENSPEHWLQNDWHTKHMNYHKKYPEKLYFEGLAEQVDPPVQIQSPYLPIYFGNVCLRFLPVFDIVIHRFLELLPVSKSLETLLDHLGGLYKFHDRPVTYLYNTLHYYEMHLRERPTLKRKLVHAIIGSLKDNRPQGWCLSDTYLKSAMNAREDNPWIPDDSYYCRLIGRLVDTMAGKSPGPFPNCDWRFNEFPNPAAHALHVTCVELMALAVSGKDVGNALLNVVLKSQPLVPRENITAWMNAIGLIITALPEPYWIVLHDRIVRVISSPSLTSETEWVGYPFRLFDFTACHQSYSEMSCSYTLALAHAVWHHSSIGQLSLIPKFLTEVLLPIVKTEFQLLYVYHLVGPFLQRFQQERTRCMIEIGVAFYDMLLNVDQCSAHLNYMDPICDFLYHMKYMFTGDSVKEQVEKIICNLKPALKLRLRFITHITKMEPAVGPPQAMNSGSPAPQPNQVPVSLPVTQ
Length1339
PositionTail
OrganismTrichechus manatus latirostris (Florida manatee)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Afrotheria> Sirenia> Trichechidae> Trichechus.
Aromaticity0.10
Grand average of hydropathy-0.005
Instability index45.04
Isoelectric point7.44
Molecular weight152961.24
Publications









Function






Annotated function


GO - Cellular Component
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP21124
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      38.14|      10|      31|     310|     319|       1
---------------------------------------------------------------------------
  310-  319 (18.69/12.19)	IFFVLFQFAS
  343-  352 (19.45/13.04)	LMWVLLQFIS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     451.90|     152|     660|      25|     217|       2
---------------------------------------------------------------------------
   32-  217 (217.58/258.78)	TPEDEKTKLISCL.GAFRQF........................WAGLSQESheqciQWIVKFVHGQHSPkrisfLYDCL..AMAVETGLLPP...RmVCESLINSDTLEWERTQLWALTFKLVRKIiGGVDykgvrdllkviLEKILTIPNTVssaVVQQLLVA..REVIAYIL...ERNACLLpAYFaVTEIRKLYPEGklphwlLGNLVSDFVDTFRP
  694-  880 (234.32/165.49)	TPHNWASHTLSCFpGPLQAFfkqnnvpqesrfnlkknveeeyrkWKSMSNEN.....DIITHFSKQGSSP.....LFLCLlwKMLLETDHINQigyR.VLERIGARALVAHVRTFADFLVYEFSTSA.GGQQ...........LNKCIEILNDM...VWKYNIVTldRLILCLAMrshEGNEAQV.CYF.IIQLLLLKPND......FRNRVSDFVKENSP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     364.06|     109|     665|     358|     532|       3
---------------------------------------------------------------------------
  362-  485 (170.45/196.24)	DFLPVMK....LFDLLYPEKECIPVPDINKPQSTHAFAMtciwiHLnRKAQNDNSKLQIPIPHSLKlHHEFLQQSLRNKSLQ..MNdykiALLCNAYSTNSECFTLPMGALVETIYGngimRIPLPGTSC
  947- 1061 (193.61/107.24)	ELLPVSKsletLLDHLGGLYKFHDRPVTYLYNTLHYYEM.....HL.RERPTLKRKLVHAIIGSLK.DNRPQGWCLSDTYLKsaMN....AREDNPWIPDDSYYCRLIGRLVDTMAG....KSPGPFPNC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     207.55|      65|      88|    1155|    1225|       4
---------------------------------------------------------------------------
 1155- 1225 (104.94/74.48)	VGYPFR..LFDFTAC..HQSYSEMSCSYtlaLAHAVWHHSSIGQLSLIPKFLTEvLLPIVKteFQLLYVYHL......VGP
 1241- 1315 (102.61/57.85)	IGVAFYdmLLNVDQCsaHLNYMDPICDF...LYHMKYMFTGDSVKEQVEKIICN.LKPALK..LRLRFITHItkmepaVGP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      63.51|      17|     874|     488|     504|       7
---------------------------------------------------------------------------
  488-  504 (30.63/21.08)	SGSITPLPMNLLDSLTV
 1321- 1337 (32.88/23.27)	SGSPAPQPNQVPVSLPV
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP21124 with Med23 domain of Kingdom Metazoa
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