<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP21124

Description mediator of RNA polymerase II transcription subunit 23 isoform X4
SequenceMVQMETQLQSIFEEVVKTEIIEEAFPGMFMDTPEDEKTKLISCLGAFRQFWAGLSQESHEQCIQWIVKFVHGQHSPKRISFLYDCLAMAVETGLLPPRMVCESLINSDTLEWERTQLWALTFKLVRKIIGGVDYKGVRDLLKVILEKILTIPNTVSSAVVQQLLVAREVIAYILERNACLLPAYFAVTEIRKLYPEGKLPHWLLGNLVSDFVDTFRPTARINSICGRCSLLPVVNNSGAICNSWKLDPATLRFPLKGLLPYDKHKQRCPVLEDQLVDLVVYAMERSETEEKFDDGGTSQLLWQHLSSQLIFFVLFQFASFPHMVLSLHQKLAGRGLIKGRDHLMWVLLQFISGSIQKNALADFLPVMKLFDLLYPEKECIPVPDINKPQSTHAFAMTCIWIHLNRKAQNDNSKLQIPIPHSLKLHHEFLQQSLRNKSLQMNDYKIALLCNAYSTNSECFTLPMGALVETIYGNGIMRIPLPGTSCVASGSITPLPMNLLDSLTVHAKMSLIHSIATRVIKLAHAKSSVALAPALVETYSRLLVYMEIESLGIKGFISQLLPTVFKSHAWGILHTLLEMFSYRMHHIQPHYRVQLLSHLHTLAAVAQTNQNQLHLCVESTALRLITALGSSEVQPQFTRFLSDPKTVLSAESEELNRALILTLARATHVTDFFTGSDSIQGTWCKDILQTIMSFTPHNWASHTLSCFPGPLQAFFKQNNVPQESRFNLKKNVEEEYRKWKSMSNENDIITHFSKQGSSPLFLCLLWKMLLETDHINQIGYRVLERIGARALVAHVRTFADFLVYEFSTSAGGQQLNKCIEILNDMVWKYNIVTLDRLILCLAMRSHEGNEAQVCYFIIQLLLLKPNDFRNRVSDFVKENSPEHWLQNDWHTKHMNYHKKYPEKLYFEGLAEQVDPPVQIQSPYLPIYFGNVCLRFLPVFDIVIHRFLELLPVSKSLETLLDHLGGLYKFHDRPVTYLYNTLHYYEMHLRERPTLKRKLVHAIIGSLKDNRPQGWCLSDTYLKSAMNAREDNPWIPDDSYYCRLIGRLVDTMAGKSPGPFPNCDWRFNEFPNPAAHALHVTCVELMALAVSGKDVGNALLNVVLKSQPLVPRENITAWMNAIGLIITALPEPYWIVLHDRIVRVISSPSLTSETEWVGYPFRLFDFTACHQSYSEMSCSYTLALAHAVWHHSSIGQLSLIPKFLTEVLLPIVKTEFQLLYVYHLVGPFLQRFQQERTRCMIEIGVAFYDMLLNVDQCSAHLNYMDPICDFLYHMKYMFTGDSVKEQVEKIICNLKPALKLRLRFITHITKMEPAVGPPQAMNSGSPAPQPNQVPVSLPVTQ
Length1339
PositionTail
OrganismTrichechus manatus latirostris (Florida manatee)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Afrotheria> Sirenia> Trichechidae> Trichechus.
Aromaticity0.10
Grand average of hydropathy-0.005
Instability index45.04
Isoelectric point7.44
Molecular weight152961.24
Publications









Function






Annotated function


GO - Cellular Component
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP21124
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      38.14|      10|      31|     310|     319|       1
---------------------------------------------------------------------------
  310-  319 (18.69/12.19)	IFFVLFQFAS
  343-  352 (19.45/13.04)	LMWVLLQFIS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     451.90|     152|     660|      25|     217|       2
---------------------------------------------------------------------------
   32-  217 (217.58/258.78)	TPEDEKTKLISCL.GAFRQF........................WAGLSQESheqciQWIVKFVHGQHSPkrisfLYDCL..AMAVETGLLPP...RmVCESLINSDTLEWERTQLWALTFKLVRKIiGGVDykgvrdllkviLEKILTIPNTVssaVVQQLLVA..REVIAYIL...ERNACLLpAYFaVTEIRKLYPEGklphwlLGNLVSDFVDTFRP
  694-  880 (234.32/165.49)	TPHNWASHTLSCFpGPLQAFfkqnnvpqesrfnlkknveeeyrkWKSMSNEN.....DIITHFSKQGSSP.....LFLCLlwKMLLETDHINQigyR.VLERIGARALVAHVRTFADFLVYEFSTSA.GGQQ...........LNKCIEILNDM...VWKYNIVTldRLILCLAMrshEGNEAQV.CYF.IIQLLLLKPND......FRNRVSDFVKENSP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     364.06|     109|     665|     358|     532|       3
---------------------------------------------------------------------------
  362-  485 (170.45/196.24)	DFLPVMK....LFDLLYPEKECIPVPDINKPQSTHAFAMtciwiHLnRKAQNDNSKLQIPIPHSLKlHHEFLQQSLRNKSLQ..MNdykiALLCNAYSTNSECFTLPMGALVETIYGngimRIPLPGTSC
  947- 1061 (193.61/107.24)	ELLPVSKsletLLDHLGGLYKFHDRPVTYLYNTLHYYEM.....HL.RERPTLKRKLVHAIIGSLK.DNRPQGWCLSDTYLKsaMN....AREDNPWIPDDSYYCRLIGRLVDTMAG....KSPGPFPNC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     207.55|      65|      88|    1155|    1225|       4
---------------------------------------------------------------------------
 1155- 1225 (104.94/74.48)	VGYPFR..LFDFTAC..HQSYSEMSCSYtlaLAHAVWHHSSIGQLSLIPKFLTEvLLPIVKteFQLLYVYHL......VGP
 1241- 1315 (102.61/57.85)	IGVAFYdmLLNVDQCsaHLNYMDPICDF...LYHMKYMFTGDSVKEQVEKIICN.LKPALK..LRLRFITHItkmepaVGP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      63.51|      17|     874|     488|     504|       7
---------------------------------------------------------------------------
  488-  504 (30.63/21.08)	SGSITPLPMNLLDSLTV
 1321- 1337 (32.88/23.27)	SGSPAPQPNQVPVSLPV
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP21124 with Med23 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




NANANA









Molecular Recognition Features






MoRF SequenceStartStop




NANANA