<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP21122

Description cyclin-dependent kinase 19 isoform X2
SequenceMDYDFKAKLAAERERVEDLFEYEGCKVGRGTYGHVYKARRKDGFQEGFVYGPQALEVADFSTEGAPVVQWLSAWLLTKRKDEKEYALKQIEGTGISMSACREIALLRELKHPNVIALQKVFLSHSDRKVWLLFDYAEHDLWHIIKFHRASKANKKPMQLPRSMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLFNSPLKPLADLDPVVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPFHHDQLDRIFSVMGFPADKDWEDIRKMPEYPTLQKDFRRTTYANSSLIKYMEKHKVKPDSKVFLLLQRLLTMDPTKRITSEQALQDPYFQEDPLPTLDVFAGCQIPYPKREFLNEDEPEEKGDKNQQQQQNQHQQPTAPPQQAAAPPPAPPQQQNSTQTNGTAGGAGAGAGGTGVGLQHSQDAGLNQVPPNKKPRLGPSGANSGGPVMPSDYQKETNLLSITKDTSSSYAYI
Length514
PositionKinase
OrganismTrichechus manatus latirostris (Florida manatee)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Afrotheria> Sirenia> Trichechidae> Trichechus.
Aromaticity0.09
Grand average of hydropathy-0.574
Instability index47.40
Isoelectric point7.68
Molecular weight58182.55
Publications









Function






Annotated function


GO - Cellular Component
GO - Biological Function
ATP binding	GO:0005524	IEA:InterPro
protein kinase activity	GO:0004672	IEA:InterPro

GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP21122
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.93|      18|      22|     410|     427|       1
---------------------------------------------------------------------------
  410-  427 (35.12/24.37)	QQQNQHQ.QPTAPPQQAAA
  434-  452 (25.81/15.77)	QQQNSTQtNGTAGGAGAGA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.89|      15|      41|     187|     201|       2
---------------------------------------------------------------------------
  187-  201 (25.86/15.95)	DLKPANILVMGEGPE
  225-  239 (27.03/16.98)	DLDPVVVTFWYRAPE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      85.18|      27|      40|     313|     345|       5
---------------------------------------------------------------------------
  313-  345 (37.01/43.82)	PTlqkdfRRTTYANSSLIKYMEKHKVkPDSKVF
  356-  382 (48.17/34.82)	PT.....KRITSEQALQDPYFQEDPL.PTLDVF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      34.01|      11|      25|      95|     106|       6
---------------------------------------------------------------------------
   95-  106 (13.53/15.48)	ISMSAcREIALL
  122-  132 (20.49/14.82)	LSHSD.RKVWLL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP21122 with CDK8 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) YPKREFLNEDEPEEKGDKNQQQQQNQHQQPTAPPQQAAAPPPAPPQQQNSTQTNGTAGGAGAGAGGTGVGLQHSQDAGLNQVPPNKKPRLGPSGANSGGPVMPSDYQKETNLLSITKDTSS
389
509










Molecular Recognition Features






MoRF SequenceStartStop




1) PNKKPRLGP
472
480