<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP21119

Description mediator of RNA polymerase II transcription subunit 23 isoform X3
SequenceMFMDTPEDEKTKLISCLGAFRQFWAGLSQESHEQCIQWIVKFVHGQHSPKRISFLYDCLAMAVETGLLPPRMVCESLINSDTLEWERTQLWALTFKLVRKIIGGVDYKGVRDLLKVILEKILTIPNTVSSAVVQQLLVAREVIAYILERNACLLPAYFAVTEIRKLYPEGKLPHWLLGNLVSDFVDTFRPTARINSICGRCSLLPVVNNSGAICNSWKLDPATLRFPLKGLLPYDKDLFEPQTALLRYVLEQPYSRDMVCNMLGLNKQHKQRCPVLEDQLVDLVVYAMERSETEEKFDDGGTSQLLWQHLSSQLIFFVLFQFASFPHMVLSLHQKLAGRGLIKGRDHLMWVLLQFISGSIQKNALADFLPVMKLFDLLYPEKECIPVPDINKPQSTHAFAMTCIWIHLNRKAQNDNSKLQIPIPHSLKLHHEFLQQSLRNKSLQMNDYKIALLCNAYSTNSECFTLPMGALVETIYGNGIMRIPLPGTSCVASGSITPLPMNLLDSLTVHAKMSLIHSIATRVIKLAHAKSSVALAPALVETYSRLLVYMEIESLGIKGFISQLLPTVFKSHAWGILHTLLEMFSYRMHHIQPHYRVQLLSHLHTLAAVAQTNQNQLHLCVESTALRLITALGSSEVQPQFTRFLSDPKTVLSAESEELNRALILTLARATHVTDFFTGSDSIQGTWCKDILQTIMSFTPHNWASHTLSCFPGPLQAFFKQNNVPQESRFNLKKNVEEEYRKWKSMSNENDIITHFSKQGSSPLFLCLLWKMLLETDHINQIGYRVLERIGARALVAHVRTFADFLVYEFSTSAGGQQLNKCIEILNDMVWKYNIVTLDRLILCLAMRSHEGNEAQVCYFIIQLLLLKPNDFRNRVSDFVKENSPEHWLQNDWHTKHMNYHKKYPEKLYFEGLAEQVDPPVQIQSPYLPIYFGNVCLRFLPVFDIVIHRFLELLPVSKSLETLLDHLGGLYKFHDRPVTYLYNTLHYYEMHLRERPTLKRKLVHAIIGSLKDNRPQGWCLSDTYLKSAMNAREDNPWIPDDSYYCRLIGRLVDTMAGKSPGPFPNCDWRFNEFPNPAAHALHVTCVELMALAVSGKDVGNALLNVVLKSQPLVPRENITAWMNAIGLIITALPEPYWIVLHDRIVRVISSPSLTSETEWVGYPFRLFDFTACHQSYSEMSCSYTLALAHAVWHHSSIGQLSLIPKFLTEVLLPIVKTEFQLLYVYHLVGPFLQRFQQERTRCMIEIGVAFYDMLLNVDQCSAHLNYMDPICDFLYHMKYMFTGDSVKEQVEKIICNLKPALKLRLRFITHITKMEPAVGPPQAMNSGSPAPQPNQVPVSLPVTQ
Length1344
PositionTail
OrganismTrichechus manatus latirostris (Florida manatee)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Afrotheria> Sirenia> Trichechidae> Trichechus.
Aromaticity0.10
Grand average of hydropathy-0.014
Instability index44.33
Isoelectric point7.95
Molecular weight153621.05
Publications









Function






Annotated function


GO - Cellular Component
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP21119
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      74.87|      21|     127|     560|     580|       1
---------------------------------------------------------------------------
  560-  580 (36.35/19.40)	FISQLLPTVFKSHAWGILHTL
  586-  606 (38.51/20.97)	YRMHHIQPHYRVQLLSHLHTL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      94.13|      26|      89|    1041|    1068|       3
---------------------------------------------------------------------------
 1041- 1068 (48.25/41.59)	DSYYCRLIGRLVDTMAgkSPGPFPNCDW
 1134- 1159 (45.88/32.32)	EPYWIVLHDRIVRVIS..SPSLTSETEW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     207.55|      65|      87|    1160|    1230|       4
---------------------------------------------------------------------------
 1160- 1230 (104.94/74.73)	VGYPFR..LFDFTAC..HQSYSEMSCSYtlaLAHAVWHHSSIGQLSLIPKFLTEvLLPIVKteFQLLYVYHL......VGP
 1246- 1320 (102.61/58.08)	IGVAFYdmLLNVDQCsaHLNYMDPICDF...LYHMKYMFTGDSVKEQVEKIICN.LKPALK..LRLRFITHItkmepaVGP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      38.14|      10|      31|     315|     324|       5
---------------------------------------------------------------------------
  315-  324 (18.69/10.32)	IFFVLFQFAS
  348-  357 (19.45/11.05)	LMWVLLQFIS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     102.25|      31|     454|     476|     507|       6
---------------------------------------------------------------------------
  476-  507 (52.64/47.25)	YGNGIMRIpLPGTSCVASGSITPLPMN.....LLDSL
  932-  967 (49.61/37.66)	FGNVCLRF.LPVFDIVIHRFLELLPVSksletLLDHL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     160.24|      51|     711|       5|      65|       7
---------------------------------------------------------------------------
    5-   65 (84.56/80.03)	TPEDEKTKLISCL.GAFRQF........................WAGLSQESheqciQWIVKFVHGQHSPkrisfLYDCL..AMAVET
  699-  776 (75.69/49.14)	TPHNWASHTLSCFpGPLQAFfkqnnvpqesrfnlkknveeeyrkWKSMSNEN.....DIITHFSKQGSSP.....LFLCLlwKMLLET
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.24|      13|     711|     164|     194|      10
---------------------------------------------------------------------------
  164-  176 (25.54/21.64)	RKLYPEGKLPHWL
  877-  889 (24.70/12.27)	SDFVKENSPEHWL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      95.95|      30|     262|     516|     549|      12
---------------------------------------------------------------------------
  516-  549 (43.92/43.02)	IHSIATRVIKLAHAKSSValapALVETYSRLLVY
  779-  808 (52.03/38.83)	INQIGYRVLERIGARALV....AHVRTFADFLVY
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP21119 with Med23 domain of Kingdom Metazoa
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