<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP21116

Description cyclin-dependent kinase 19 isoform X1
SequenceMDYDFKAKLAAERERVEDLFEYEGCKVGRGTYGHVYKARRKDGFQEGFVYGPQALEVADFSTEGAPVVQWLSAWLLTKRKDEKEYALKQIEGTGISMSACREIALLRELKHPNVIALQKVFLSHSDRKVWLLFDYAEHDLWHIIKFHRASKANKKPMQLPRSMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLFNSPLKPLADLDPVVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPFHHDQLDRIFSVMGFPADKDWEDIRKMPEYPTLQKDFRRTTYANSSLIKYMEKHKVKPDSKVFLLLQRLLTMDPTKRITSEQALQDPYFQEDPLPTLDVFAGCQIPYPKREFLNEDEPEEKGDKNQQQQQNQHQQPTAPPQQAAAPPPAPPQQQNSTQTNGTAGGAGAGAGGTGVGLQHSQDAGLNQVPPNKKPRLGPSGANSGGPVMPSDYQHSTSRLNYQSSVQGSSQSQSTLGYSSSAQQSAQYHPSHQGHRY
Length538
PositionKinase
OrganismTrichechus manatus latirostris (Florida manatee)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Afrotheria> Sirenia> Trichechidae> Trichechus.
Aromaticity0.09
Grand average of hydropathy-0.641
Instability index51.36
Isoelectric point8.34
Molecular weight60789.07
Publications









Function






Annotated function


GO - Cellular Component
GO - Biological Function
ATP binding	GO:0005524	IEA:InterPro
protein kinase activity	GO:0004672	IEA:InterPro

GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP21116
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     141.49|      36|      37|     460|     496|       1
---------------------------------------------------------------------------
  414-  455 (34.05/10.17)	QHQQPTAPP.....QqaaAPPPAPPQqqnstqtngtAG.GAGAGAGGT.......
  460-  495 (67.76/29.11)	QHSQDAGLN.....Q...VPPNKKPR..........LG.PSGANSGGPVMPSDYQ
  499-  535 (39.68/14.72)	SR.....LNyqssvQ...GSSQSQST..........LGySSSAQQSAQYHPSHQG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      67.35|      15|      37|     187|     201|       5
---------------------------------------------------------------------------
  187-  201 (25.86/16.34)	DLKPANILVMGEGPE
  209-  219 (14.46/ 6.09)	DMGFARLF...NSP.
  225-  239 (27.03/17.39)	DLDPVVVTFWYRAPE
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP21116 with CDK8 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) YPKREFLNEDEPEEKGDKNQQQQQNQHQQPTAPPQQAAAPPPAPPQQQNSTQTNGTAGGAGAGAGGTGVGLQHSQDAGLNQVPPNKKPRLGPSGANSGGPVMPSDYQHSTSRLNYQSSVQGSSQSQSTLGYSSSAQQSAQYHPSHQGHRY
389
538










Molecular Recognition Features






MoRF SequenceStartStop




1) KKPRLG
2) TLGYSSSAQQSAQYHPSHQ
474
516
479
534