<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP21112

Description cyclin-dependent kinase 19 isoform X4
SequenceMIPGGLRVWTSSVGGSRLFNRRKDEKEYALKQIEGTGISMSACREIALLRELKHPNVIALQKVFLSHSDRKVWLLFDYAEHDLWHIIKFHRASKANKKPMQLPRSMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLFNSPLKPLADLDPVVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPFHHDQLDRIFSVMGFPADKDWEDIRKMPEYPTLQKDFRRTTYANSSLIKYMEKHKVKPDSKVFLLLQRLLTMDPTKRITSEQALQDPYFQEDPLPTLDVFAGCQIPYPKREFLNEDEPEEKGDKNQQQQQNQHQQPTAPPQQAAAPPPAPPQQQNSTQTNGTAGGAGAGAGGTGVGLQHSQDAGLNQVPPNKKPRLGPSGANSGGPVMPSDYQHSTSRLNYQSSVQGSSQSQSTLGYSSSAQQSAQYHPSHQGHRY
Length481
PositionKinase
OrganismTrichechus manatus latirostris (Florida manatee)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Afrotheria> Sirenia> Trichechidae> Trichechus.
Aromaticity0.08
Grand average of hydropathy-0.635
Instability index56.03
Isoelectric point9.07
Molecular weight54153.78
Publications









Function






Annotated function


GO - Cellular Component
GO - Biological Function
ATP binding	GO:0005524	IEA:InterPro
protein kinase activity	GO:0004672	IEA:InterPro

GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP21112
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     141.49|      36|      37|     403|     439|       1
---------------------------------------------------------------------------
  357-  398 (34.05/ 9.57)	QHQQPTAPP.....QqaaAPPPAPPQqqnstqtngtAG.GAGAGAGGT.......
  403-  438 (67.76/27.84)	QHSQDAGLN.....Q...VPPNKKPR..........LG.PSGANSGGPVMPSDYQ
  442-  478 (39.68/13.96)	SR.....LNyqssvQ...GSSQSQST..........LGySSSAQQSAQYHPSHQG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.44|      15|      41|     130|     144|       2
---------------------------------------------------------------------------
  130-  144 (26.77/16.02)	DLKPANILVMGEGPE
  168-  182 (28.67/17.60)	DLDPVVVTFWYRAPE
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP21112 with CDK8 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) YPKREFLNEDEPEEKGDKNQQQQQNQHQQPTAPPQQAAAPPPAPPQQQNSTQTNGTAGGAGAGAGGTGVGLQHSQDAGLNQVPPNKKPRLGPSGANSGGPVMPSDYQHSTSRLNYQSSVQGSSQSQSTLGYSSSAQQSAQYHPSHQGHRY
332
481










Molecular Recognition Features






MoRF SequenceStartStop




1) KKPRL
2) TLGYSSSAQQSAQYHPSHQ
417
459
421
477